Newest first

New topics page 37

Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 37 of 40

Topic	Participants	Replies	Views	Activity
Journal club: indirect comparison between two programmes, defended and attacked — one year on Evidence › Journal club randomised trial risk of bias effect size estimand Posting this under the heading it deserves: Journal club: indirect comparison between two programmes, defended and attacked — one year on Everything below is what sits behind that. Asking about indirect…	+45	50	3k	9mo
About the Semaglutide category Compounds › Semaglutide semaglutide STEP programme SELECT trial Pinned Wiki Closed GLP-1 receptor agonist. Dosing, published trial data, tolerability, and formulation questions. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…		4	4.2k	11mo
Import rules for personal quantities, by jurisdiction, dated Sourcing › Regulatory compounding MHRA FDA personal import On the subject in the title: Import rules for personal quantities, by jurisdiction, dated Working notes rather than a conclusion. I was wrong about import rules for personal quantities in a thread last spring…		3	60k	12mo
Coming back to: Oxidation and deamidation mass shifts, tabulated Analytics › Mass spectrometry LC-MS charge states MALDI-TOF high-resolution MS Oxidation and deamidation mass shifts, tabulated — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about Oxidation and deamidation mass…	+34	38	4.8k	10mo
How to bring a laboratory report to an appointment usefully Clinical › Bloodwork thyroid function lipase & amylase lipid panel eGFR & renal function How to bring a laboratory report to an appointment usefully — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about bring a laboratory directly, because I have…		2	41k	14mo
A well-designed study with a badly written abstract Evidence › Study critique disputed effect size risk of bias observational data Posting this under the heading it deserves: A well-designed study with a badly written abstract Everything below is what sits behind that. Reading back through what has been written here about well-designed…	+117	128	7.2k	14mo
Coming back to: Over-dilution: when your dose falls below one readable graduation Practice › Reconstitution worked example dead volume syringe units bacteriostatic water Over-dilution: when your dose falls below one readable graduation Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a…	+90	97	1.1k	7mo
A certificate with no method stated: what can you conclude? Analytics › COA interpretation certificate of analysis batch & lot numbers documentation quality Solved A certificate with no method stated: what can you conclude? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means before I…	+49	57	1.2k	16mo
Retatrutide phase 2 in type 2 diabetes: the Lancet paper Compounds › Retatrutide randomised trial preprint effect size retatrutide Solved Closed On the subject in the title: Retatrutide phase 2 in type 2 diabetes: the Lancet paper Working notes rather than a conclusion. Asking about retatrutide phase 2 in type on behalf of the question I keep seeing…	+12	16	50k	12mo
Review cadence: how often is a page actually re-checked? Documentation › Doc review maintainership review date promoted to docs Solved Asking directly, because I could not find a straight answer: Review cadence: how often is a page actually re-checked? I would like to know what people here actually do about review cadence, as distinct from…	+20	24	20k	15mo
[2026 update] Building a sensible monitoring schedule with your prescriber Clinical › Bloodwork thyroid function HbA1c lipid panel lipase & amylase Closed Posting this under the heading it deserves: Building a sensible monitoring schedule with your prescriber Everything below is what sits behind that. Reading back through what has been written here about…	+22	26	5.1k	14mo
Excipient function in a licensed injectable Pharmacology › Formulation chemistry bacteriostatic water cloudy or discoloured solution sterile water Solved Wiki Closed Excipient function in a licensed injectable Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about excipient function in a thread last spring and I would like to…	+3	7	36k	14mo
Sequence verification for an obscure compound: how it is done Compounds › Other compounds needs a source custom synthesis research use only mislabelling Sequence verification for an obscure compound: how it is done Writing it up because I had to work it out twice and would rather nobody else did. Asking about sequence verification directly, because I have…	+104	114	10k	12mo
Second pass at: Reading a combination trial: attributing effect to components Compounds › Cagrilintide & amylin analogues cagrilintide randomised trial amylin analogues effect size Second pass at: Reading a combination trial: attributing effect to components — setting out what I have, and where I think it stops being reliable. The question about Reading a combination trial that I…	+39	43	7.3k	12mo
Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Compounds › Tirzepatide SURMOUNT programme tirzepatide randomised trial effect size Posting this under the heading it deserves: Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Everything below is what sits behind that. Reading back through what has been written here about…	+4	8	14k	8mo
Needle changes between doses on a reusable pen Devices › Pens & autoinjectors subcutaneous injection dead volume missed dose storage Posting this under the heading it deserves: Needle changes between doses on a reusable pen Everything below is what sits behind that. The question about needle changes between doses that I actually want…	+34	38	1.5k	10mo
Coming back to: Cross-border purchase rules within the EU Regional › European Union EMA cost per milligram personal import Cross-border purchase rules within the EU Writing it up because I had to work it out twice and would rather nobody else did. Cross-border purchase rules within — I have the observation and I do not trust my…	+12	16	2.8k	11mo
Coming back to: A critique that turned out to be unfair, retracted by its author Evidence › Study critique disputed observational data effect size confounding Closed A critique that turned out to be unfair, retracted by its author — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about critique, three…		2	1.3k	14mo
Comparators chosen for regulatory reasons rather than clinical ones — one year on Evidence › Trials randomised trial intention to treat open label estimand Solved Comparators chosen for regulatory reasons rather than clinical ones — one year on — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Comparators chosen for…	+82	87	1.1k	12mo
Aggregated purity results across four services, with caveats Data & Tools › Datasets observational data site feedback data table Posting this under the heading it deserves: Aggregated purity results across four services, with caveats Everything below is what sits behind that. Aggregated purity results across four, from the point of…		3	24k	9mo
An appeal that failed, and what I would do differently Access › Insurance & coverage insurance appeals prior authorisation An appeal that failed, and what I would do differently Writing it up because I had to work it out twice and would rather nobody else did. Asking about appeal directly, because I have read four threads on it…	+4	8	125	12mo
Why cagrilintide alone is discussed so much less than in combination Compounds › Cagrilintide & amylin analogues effect size amylin analogues cagrisema Solved Closed Why cagrilintide alone is discussed so much less than in combination I have a specific reason for asking rather than idle curiosity, and the context is below. Collecting what is known about cagrilintide alone…	+93	108	35k	16mo
Publishing an inconvenient result: a case study Sourcing › Independent verification Medutest VendorInvestigate third-party testing Janoshik Analytical Wiki On the subject in the title: Publishing an inconvenient result: a case study Working notes rather than a conclusion. Publishing an inconvenient result, and specifically the version of it that the…	+59	70	992	11mo
Coming back to: Why quantitation is the hard part, not detection Analytics › Home & field testing third-party testing documentation quality ELISA LOD & LOQ Why quantitation is the hard part, not detection — that is the question, and I have not found it answered plainly anywhere I have looked. Collecting what is known about quantitation in one place, because it…	+86	92	54k	8mo
Follow-up: The lowest dose that does anything: is that a real question? Practice › Dosing & titration worked example missed dose tirzepatide dose reduction Closed The question in the title: The lowest dose that does anything: is that a real question? I will give what I have already checked below so nobody repeats it. I have read the maintained page on this and I still…	+70	75	12k	8mo
A supplier who responds to a discrepancy with silence Sourcing › Red flags underdosing documentation quality moderation mislabelling Closed On the subject in the title: A supplier who responds to a discrepancy with silence Working notes rather than a conclusion. Two things I would like separated before anyone answers on supplier, because they get…		2	6.1k	16mo
What happens after your first post: likes, trust levels, and why none of it matters much Start Here › Welcome guidelines beginner friendly trust levels onboarding Solved Asking directly, because I could not find a straight answer: What happens after your first post: likes, trust levels, and why none of it matters much I want to check my reasoning rather than get a conclusion.…	+15	19	17k	16mo
Documenting a supplier's response to a discrepancy — does this still hold? Sourcing › Vendor reports certificate of analysis third-party testing batch & lot numbers Documenting a supplier's response to a discrepancy — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Structured question about turnaround and…	+47	52	58k	16mo
Units, standards, and other things that quietly hold the world together Lounge › Off topic long read beginner friendly Closed Units, standards, and other things that quietly hold the world together — setting out what I have, and where I think it stops being reliable. I was wrong about units in a thread last spring and I would like…	+33	38	31k	15mo
Asking about a compound your prescriber has not heard of Clinical › Prescriber conversations telehealth prior authorisation beginner friendly Asking about a compound your prescriber has not heard of Writing it up because I had to work it out twice and would rather nobody else did. A question about how to describe something to a clinician rather…	+137	148	15k	11mo