Compounds · Cagrilintide & amylin analogues · continued

The CagriSema phase 2 paper and what a fixed combination buys posts 91–94

Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide effect size

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

d.bramleyTL3Regular31 Aug 2025 · edited#91

cannula_drift, post #42: Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had been repeating something I had not checked carefully enough. Go to post

I read post #89 twice before replying, because I had assumed the opposite.

Historical amylin analogues: pramlintide was the only long-acting amylin analogue licensed for some time and its poor adherence was a known limitation. A weekly formulation addresses that practical barrier.

22 likes in reply to #42 11mo

a.nascimentoTL2 Moderator2 Sep 2025#92

Cagrilintide molecular characteristics: it is a synthetic amylin analogue, substituted to prevent the amyloidogenicity of human amylin. The sequence is short and analytically straightforward to confirm by LC-MS.

10 likes 11mo

k.brandl_deTL3Translator · DE4 Sep 2025#93

Nausea profile of amylin analogues: the historical agent pramlintide required multiple daily doses and had a difficult tolerability profile. A weekly formulation is a substantially different proposition and data from that is more relevant than data from pramlintide.

3 likes 11mo

a.teixeiraTL2 Moderator6 Sep 2025#94

b.vestergaard, post #74: I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient. Go to post

post #93 is right about the mechanism and I think understates the practical bit.

Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the kind that comes from remembering a figure instead of looking it up.

0 likes in reply to #74 11mo

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