Ranked by engagement

Top topics — all time page 40

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 40 of 40

Topic	Participants	Replies	Views	Activity
[2026 update] Evidence quality in the secretagogue literature: an honest assessment Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin Closed Posting this under the heading it deserves: Evidence quality in the secretagogue literature: an honest assessment Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with STEP 1 ( N…	+14	18	3.1k	6mo
What to include when your question involves a laboratory result Start Here › How to Ask beginner friendly site feedback guidelines Asking directly, because I could not find a straight answer: What to include when your question involves a laboratory result Question in the title. Context below, and I have tried to include the things people…	+8	12	14k	2d
Is "synergy" the right word for the combination data? Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide effect size Is "synergy" the right word for the combination data? — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SCALE ( N Engl J Med , 2015). Please read it…	+5	9	13k	25d
Alcohol: what is documented and what is folklore — the long version Practice › Interactions insulin needs a source delayed gastric emptying metformin Solved Alcohol: what is documented and what is folklore — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern…	+9	13	7.3k	6mo
Follow-up: What is genuinely unknown about long-term amylin agonism Compounds › Cagrilintide & amylin analogues effect size amylin analogues cagrisema What is genuinely unknown about long-term amylin agonism I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support…		2	25k	11mo
Long-time reader, first-time poster Lounge › Introductions beginner friendly onboarding On the subject in the title: Long-time reader, first-time poster Working notes rather than a conclusion. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim. Something adjacent…	+15	19	2.5k	8mo
Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold? Clinical › Special populations disordered eating chronic kidney disease pregnancy & planning Solved Asking directly, because I could not find a straight answer: Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold? General question, not a request for advice about my own…		2	22k	11mo
Second pass at: What to keep a record of at the point of payment Sourcing › Payments payments research use only documentation quality Second pass at: What to keep a record of at the point of payment — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…	+14	18	1.9k	4mo
A comparison of home results against a laboratory result on the same vial — does this still hold? Analytics › Home & field testing ELISA third-party testing LOD & LOQ documentation quality Solved A comparison of home results against a laboratory result on the same vial — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Working through the…	+2	6	15k	11h
Coming back to: Reconstitution volumes that produce round numbers, tabulated Practice › Reconstitution concentration maths syringe units bacteriostatic water dead volume On the subject in the title: Reconstitution volumes that produce round numbers, tabulated Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly…		2	24k	6mo
Second pass at: Counter-ion content and its effect on measured mass Analytics › Mass spectrometry mass error (ppm) counter-ion content MALDI-TOF charge states Solved Second pass at: Counter-ion content and its effect on measured mass Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like…		4	16k	4mo
Trust level 3 requirements: a clarification Meta › Announcements guidelines site feedback moderation Trust level 3 requirements: a clarification — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic in question keeps…	+10	14	7k	9mo
Over-dilution: when your dose falls below one readable graduation Practice › Reconstitution concentration maths syringe units bacteriostatic water dead volume On the subject in the title: Over-dilution: when your dose falls below one readable graduation Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am…	+15	19	248	15mo
[2026 update] Comparing tirzepatide and semaglutide is harder than the tables suggest Compounds › Tirzepatide effect size SURMOUNT programme tirzepatide randomised trial Comparing tirzepatide and semaglutide is harder than the tables suggest Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with SURMOUNT-1…		2	23k	21mo
Follow-up: Attributing a new peak: degradation product or excipient? Analytics › Impurities & related substances water content HPLC forced degradation endotoxin testing Solved Attributing a new peak: degradation product or excipient? I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first…	+15	19	671	17mo
Cold packs, phase-change material, and what survives ten days — does this still hold? Sourcing › Logistics packaging temperature excursion customs shipping Asking directly, because I could not find a straight answer: Cold packs, phase-change material, and what survives ten days — does this still hold? A logistics question, since the answers here are usually…		2	22k	22mo
What a confidence interval means, from scratch — the long version Research Methods › Statistics effect size worked example confounding number needed to treat The question in the title: What a confidence interval means, from scratch — the long version I will give what I have already checked below so nobody repeats it. I have seen SURMOUNT-2 ( Lancet , 2023) cited…	+16	20	2.3k	8mo
Subcutaneous absorption kinetics and site differences Pharmacology › Pharmacokinetics missed dose worked example semaglutide Wiki Posting this under the heading it deserves: Subcutaneous absorption kinetics and site differences Everything below is what sits behind that. I would like to understand what this number means before I repeat…	+15	19	3.9k	12mo
About the Reconstitution category Practice › Reconstitution reconstitution concentration maths syringe units Pinned Wiki Diluent choice, volumes, resulting concentrations, worked examples, and the errors we see most often. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+1	5	15k	16h
Coming back to: Cross-border purchase rules within the EU Regional › European Union EMA cost per milligram personal import Cross-border purchase rules within the EU Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that is what…	+12	16	2.8k	11mo
Introducing myself and asking whether my planned first topic belongs anywhere Start Here › Welcome onboarding beginner friendly guidelines Closed Introducing myself and asking whether my planned first topic belongs anywhere Writing it up because I had to work it out twice and would rather nobody else did. I want to check my reasoning rather than get a…	+13	18	4.2k	16mo
About the Pricing category Access › Pricing cost per milligram formulary compounding Pinned Wiki List prices, negotiated prices, and cost per milligram compared honestly across formats. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+1	5	18k	15mo
Follow-up: External review after an internal denial Access › Insurance & coverage prior authorisation formulary insurance Solved Posting this under the heading it deserves: External review after an internal denial Everything below is what sits behind that. A coverage question with the paperwork detail included, since that is what…	+6	10	12k	15h
What happens when a maintainer goes quiet Documentation › Doc review wiki post citation check maintainership promoted to docs Solved The question in the title: What happens when a maintainer goes quiet I will give what I have already checked below so nobody repeats it. Nominating something for promotion into the documentation commons. The…	+3	7	13k	2.1y
About the Repair & healing peptides category Compounds › Repair & healing peptides BPC-157 TB-500 observational data Pinned Wiki BPC-157, TB-500 and similar. Mostly preclinical evidence; this subcategory is strict about not overstating it. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…		4	19k	13mo
When your prescriber and the evidence disagree Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes When your prescriber and the evidence disagree — that is the question, and I have not found it answered plainly anywhere I have looked. General question, not a request for advice about my own care — I know…	+14	18	273	2d
Why retatrutide discussion here is more cautious than elsewhere Compounds › Retatrutide randomised trial effect size retatrutide preprint Solved Why retatrutide discussion here is more cautious than elsewhere I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited…	+7	12	7.7k	2mo
Oral versus injectable exposure: comparing apples to a different fruit Compounds › Oral incretins oral semaglutide SOUL trial PIONEER programme randomised trial Oral versus injectable exposure: comparing apples to a different fruit — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with SURMOUNT-4 ( JAMA ,…	+19	23	332	8mo
Whether an aggregate is worth publishing at all: a disputed topic — does this still hold? Data & Tools › Datasets data table confounding observational data Solved Whether an aggregate is worth publishing at all: a disputed topic — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand…	+14	18	3.4k	2mo
Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Compounds › Tirzepatide SURMOUNT programme tirzepatide randomised trial effect size Posting this under the heading it deserves: Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Everything below is what sits behind that. I have seen SCALE ( N Engl J Med , 2015) cited in support…	+4	8	14k	8mo