Latest topics page 34

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 34 of 52

Topic	Participants	Replies	Views	Activity
Severe abdominal pain: why this is not a forum question — one year on Safety › Adverse events pancreatitis delayed gastric emptying gallbladder vomiting Closed Severe abdominal pain: why this is not a forum question — one year on — setting out what I have, and where I think it stops being reliable. A narrow question about Severe abdominal pain, deliberately narrow,…		2	49k	10mo
Coming back to: What published stability data actually covers, and what it does not Practice › Storage & stability cold chain freeze-thaw storage beyond-use date Solved Closed The question in the title: What published stability data actually covers, and what it does not I will give what I have already checked below so nobody repeats it. Reading back through what has been written…	+136	148	20k	10mo
Escalating every six weeks instead of four: what I observed over eight months — one year on Practice › Dosing & titration missed dose semaglutide dose reduction titration On the subject in the title: Escalating every six weeks instead of four: what I observed over eight months — one year on Working notes rather than a conclusion. Asking about Escalating every six weeks instead…	+55	59	9.1k	10mo
Journal club: STEP 3 and the intensive behavioural therapy floor — does this still hold? Evidence › Journal club journal club effect size number needed to treat Solved The question in the title: Journal club: STEP 3 and the intensive behavioural therapy floor — does this still hold? I will give what I have already checked below so nobody repeats it. Asking about STEP 3 on…		2	15k	10mo
Column chemistry choices for a 40-residue peptide Analytics › HPLC & UHPLC gradient method system suitability HPLC peak integration Column chemistry choices for a 40-residue peptide — setting out what I have, and where I think it stops being reliable. Collecting what is known about column chemistry choices in one place, because it is…	+39	43	1.1k	10mo
Why fasting instructions for oral semaglutide are not optional advice — does this still hold? Compounds › Oral incretins orforglipron SOUL trial PIONEER programme randomised trial Solved Asking directly, because I could not find a straight answer: Why fasting instructions for oral semaglutide are not optional advice — does this still hold? A methods question rather than a substantive one,…	+98	106	3.1k	10mo
Analytical identity of BPC-157: a 15-mer with a simple mass Compounds › Repair & healing peptides BPC-157 observational data needs a source preprint Analytical identity of BPC-157: a 15-mer with a simple mass Writing it up because I had to work it out twice and would rather nobody else did. Something about analytical identity of BPC-157 does not reconcile…	+3	7	5.2k	10mo
Titles that describe the question, not the situation — what changed since Start Here › How to Ask beginner friendly site feedback worked example guidelines Posting this under the heading it deserves: Titles that describe the question, not the situation — what changed since Everything below is what sits behind that. What changes if the standard account of Titles…	+29	33	29k	10mo
A ten-fold dose error caught before injection Devices › Syringes & needles needle gauge & length worked example syringe units dead volume Closed A ten-fold dose error caught before injection — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on ten-fold dose error caught, before…	+95	103	26k	10mo
What this community means by "a source", in practical terms Start Here › Welcome beginner friendly trust levels guidelines Solved Asking directly, because I could not find a straight answer: What this community means by "a source", in practical terms Counting it rather than describing it, because the count is the part that can be argued…	+104	122	1.9k	10mo
The retatrutide phase 2 obesity paper, read closely Compounds › Retatrutide preprint effect size TRIUMPH programme Posting this under the heading it deserves: The retatrutide phase 2 obesity paper, read closely Everything below is what sits behind that. Retatrutide phase 2 obesity paper, from the point of view of someone…		2	65k	10mo
Freeze-thaw and why one cycle is not the same as five — a second dataset Practice › Storage & stability storage beyond-use date freeze-thaw Freeze-thaw and why one cycle is not the same as five — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Freeze-thaw. It is mine, it is…	+47	55	46k	10mo
Hepatic impairment and the absence of data Clinical › Special populations older adults adolescents chronic kidney disease disordered eating Hepatic impairment and the absence of data — setting out what I have, and where I think it stops being reliable. I was wrong about hepatic impairment in a thread last spring and I would like to correct it…	+30	35	32k	10mo
Reverse causation in a cohort study of weight and outcome — a second dataset Evidence › Study critique risk of bias observational data confounding Reverse causation in a cohort study of weight and outcome — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Reverse causation. It…	+112	131	1.5k	10mo
Follow-up: History of disordered eating and why it changes the conversation Clinical › Special populations bariatric surgery history older adults pregnancy & planning chronic kidney disease Posting this under the heading it deserves: History of disordered eating and why it changes the conversation Everything below is what sits behind that. What changes if the standard account of History of…	+75	81	23k	10mo
Documenting an adverse event properly Safety › Adverse events gallbladder delayed gastric emptying vomiting hypoglycaemia Wiki Closed On the subject in the title: Documenting an adverse event properly Working notes rather than a conclusion. Asking about documenting an adverse event on behalf of the question I keep seeing asked badly,…	+6	10	2.8k	10mo
Second pass at: LOD and LOQ: definitions people get wrong Analytics › Method validation recovery precision & repeatability linearity LOD & LOQ Posting this under the heading it deserves: Second pass at: LOD and LOQ: definitions people get wrong Everything below is what sits behind that. Something about LOD and LOQ does not reconcile and I would like…	+47	51	40k	10mo
Regional warehouse stock versus direct despatch Sourcing › Logistics customs cold chain shipping Posting this under the heading it deserves: Regional warehouse stock versus direct despatch Everything below is what sits behind that. Asking about regional warehouse stock versus direct on behalf of the…	+8	12	171	10mo
[2026 update] What the GIP component of tirzepatide is thought to contribute, and how confident we can be Compounds › Tirzepatide SURPASS programme randomised trial effect size Under review The question in the title: What the GIP component of tirzepatide is thought to contribute, and how confident we can be I will give what I have already checked below so nobody repeats it. I would like to know…	+109	124	31k	10mo
Reflectance and photometric devices: precision in practice Analytics › Home & field testing third-party testing documentation quality LOD & LOQ Solved On the subject in the title: Reflectance and photometric devices: precision in practice Working notes rather than a conclusion. I was wrong about reflectance and photometric devices in a thread last spring…		2	2.2k	10mo
Second pass at: A history of disordered eating: proceeding carefully Wellbeing › Mental health disordered eating mood beginner friendly Closed On the subject in the title: Second pass at: A history of disordered eating: proceeding carefully Working notes rather than a conclusion. Two things I would like separated before anyone answers on history of…	+125	132	51k	10mo
[2026 update] Sulphur-smelling eructation: mechanism and what helps Practice › Side effects fatigue delayed gastric emptying hair shedding vomiting Posting this under the heading it deserves: Sulphur-smelling eructation: mechanism and what helps Everything below is what sits behind that. I was wrong about Sulphur-smelling eructation in a thread last…		2	7.3k	10mo
[2026 update] US compounding rules and how they changed Regional › North America FDA compounding insurance Solved US compounding rules and how they changed Writing it up because I had to work it out twice and would rather nobody else did. Regional question, dated January 2026, because everything in this category expires.…	+32	37	7.4k	10mo
Pages past their review date, listed Meta › Wiki maintenance wiki post maintainership review date moderation Pages past their review date, listed Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on pages past. It is mine, it is uncontrolled, and the method is…	+26	30	6.4k	10mo
Aggregated purity results across four services, with caveats — a second dataset Data & Tools › Datasets data table confounding site feedback observational data Closed Aggregated purity results across four services, with caveats — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Aggregated purity results…	+127	151	42k	10mo
Reaching a dose and staying there for a year: a longitudinal note — does this still hold? Practice › Dosing & titration missed dose tirzepatide dose reduction titration Solved Asking directly, because I could not find a straight answer: Reaching a dose and staying there for a year: a longitudinal note — does this still hold? I have read the maintained page on this and I still have…	+35	39	547	11mo
DXA precision and the least significant change for lean mass — what changed since Outcomes › Body composition DXA data table lean mass loss bioimpedance Solved DXA precision and the least significant change for lean mass — what changed since — setting out what I have, and where I think it stops being reliable. A question about measurement precision rather than about…		2	56k	11mo
Micronutrient status when intake falls substantially Clinical › Bloodwork lipase & amylase thyroid function lipid panel HbA1c Solved Wiki Closed On the subject in the title: Micronutrient status when intake falls substantially Working notes rather than a conclusion. Posting a small dataset on micronutrient status. It is mine, it is uncontrolled, and…	+26	30	367	11mo
Follow-up: Journal club: orforglipron phase 2 and the non-peptide question Evidence › Journal club randomised trial risk of bias effect size number needed to treat Posting this under the heading it deserves: Journal club: orforglipron phase 2 and the non-peptide question Everything below is what sits behind that. A follow-up question about orforglipron phase 2 that I…	+80	91	10k	11mo
Fatigue in the first month: how much is the drug and how much is intake — what changed since Practice › Side effects nausea constipation hair shedding Closed Fatigue in the first month: how much is the drug and how much is intake — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Something changed and I would…	+77	82	1.2k	11mo