Latest topics page 36

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 36 of 52

Topic	Participants	Replies	Views	Activity
Tirzepatide molecular mass and the charge states you would expect on ESI Compounds › Tirzepatide effect size SURPASS programme SURMOUNT programme randomised trial Tirzepatide molecular mass and the charge states you would expect on ESI Writing it up because I had to work it out twice and would rather nobody else did. Tirzepatide molecular mass keeps being re-asked here…	+36	40	44k	11mo
Coming back to: Lurking for two months before posting: was that the right call? Start Here › Welcome beginner friendly trust levels onboarding Solved The question in the title: Lurking for two months before posting: was that the right call? I will give what I have already checked below so nobody repeats it. Checking my reasoning rather than asking for a…	+28	32	3.3k	11mo
[2026 update] Cardiovascular risk: reading the outcome trials as a set Clinical › Comorbidities PCOS type 2 diabetes chronic kidney disease blood pressure Posting this under the heading it deserves: Cardiovascular risk: reading the outcome trials as a set Everything below is what sits behind that. I have spent a fortnight trying to pin Cardiovascular risk down…	+99	103	32k	11mo
Reconstituting a multi-strength kit without mixing yourself up Practice › Reconstitution reconstitution concentration maths syringe units Wiki Reconstituting a multi-strength kit without mixing yourself up Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin reconstituting a…	+108	123	30k	11mo
TB-500 and thymosin beta-4: the fragment versus the protein Compounds › Repair & healing peptides observational data TB-500 BPC-157 preprint TB-500 and thymosin beta-4: the fragment versus the protein Writing it up because I had to work it out twice and would rather nobody else did. TB-500 and thymosin beta-4: what I expected, what I found, and…	+107	118	22k	11mo
Why most self-reports here are not experiments, and that is fine Research Methods › N-of-1 designs confounding worked example data table effect size Closed Why most self-reports here are not experiments, and that is fine — that is the question, and I have not found it answered plainly anywhere I have looked. A question about what a single-person experiment can…		2	46k	11mo
Foaming during reconstitution and whether it matters Practice › Reconstitution concentration maths bacteriostatic water reconstitution syringe units Posting this under the heading it deserves: Foaming during reconstitution and whether it matters Everything below is what sits behind that. A follow-up question about foaming during reconstitution that I did…	+19	24	466	11mo
Second pass at: Isotonicity and what happens when you get it wrong Pharmacology › Formulation chemistry counter-ion content storage bacteriostatic water sterile water Closed Second pass at: Isotonicity and what happens when you get it wrong — setting out what I have, and where I think it stops being reliable. Something about Isotonicity does not reconcile and I would like a…	+1	5	2.6k	11mo
The "under review" status pill and when a moderator applies it — a second dataset Evidence › Preprints needs a source risk of bias preprint effect size The "under review" status pill and when a moderator applies it — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. A question about how this site should cite…	+50	54	1.4k	11mo
[2026 update] Journal club: is percentage weight change the right endpoint? Evidence › Journal club effect size risk of bias randomised trial Journal club: is percentage weight change the right endpoint? — that is the question, and I have not found it answered plainly anywhere I have looked. A question about what the numbers mean rather than what…	+105	118	18k	11mo
Cross-border purchase within the EU: the actual rules Access › International MHRA EMA telehealth NHS Solved Cross-border purchase within the EU: the actual rules Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers on cross-border…	+6	10	41k	11mo
[2026 update] Cold solution and stinging: the simplest fix Practice › Administration subcutaneous injection needle gauge & length aseptic technique injection site reaction Cold solution and stinging: the simplest fix — setting out what I have, and where I think it stops being reliable. A follow-up question about Cold solution and stinging that I did not know to ask the first…	+6	10	496	11mo
Preparing for an appointment: one page, three questions Clinical › Prescriber conversations prior authorisation type 2 diabetes telehealth Posting this under the heading it deserves: Preparing for an appointment: one page, three questions Everything below is what sits behind that. A question about how to describe something to a clinician rather…	+28	32	57k	11mo
Reading a combination trial: attributing effect to components Compounds › Cagrilintide & amylin analogues cagrisema amylin analogues effect size cagrilintide Closed On the subject in the title: Reading a combination trial: attributing effect to components Working notes rather than a conclusion. Collecting what is known about reading a combination trial in one place,…		4	19k	11mo
Publishing an inconvenient result: a case study Sourcing › Independent verification Medutest VendorInvestigate third-party testing Janoshik Analytical Wiki On the subject in the title: Publishing an inconvenient result: a case study Working notes rather than a conclusion. Publishing an inconvenient result, and specifically the version of it that the…	+59	70	992	11mo
Why "add 2 mL" is not an instruction — a second dataset Practice › Reconstitution concentration maths bacteriostatic water worked example dead volume Why "add 2 mL" is not an instruction — a second dataset — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still have a gap,…		2	13k	11mo
Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold? Clinical › Special populations disordered eating chronic kidney disease pregnancy & planning Solved Asking directly, because I could not find a straight answer: Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold? Older adults: setting out the arithmetic in full,…		2	22k	11mo
What a documentation review can and cannot tell you Sourcing › Independent verification Medutest VendorInvestigate Janoshik Analytical blind sampling Solved Wiki What a documentation review can and cannot tell you — that is the question, and I have not found it answered plainly anywhere I have looked. Something about documentation review does not reconcile and I would…	+79	83	950	11mo
[2026 update] Mood changes: monitoring, and when to involve a professional Wellbeing › Mental health beginner friendly mood disordered eating Posting this under the heading it deserves: Mood changes: monitoring, and when to involve a professional Everything below is what sits behind that. Something that has come up for me and that I suspect is more…	+12	17	300	11mo
[2026 update] Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Compounds › Tirzepatide tirzepatide effect size randomised trial Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about Tirzepatide in…		2	58k	11mo
Multiplicity when you track fifteen variables Research Methods › Statistics effect size heterogeneity confounding worked example Solved Multiplicity when you track fifteen variables — setting out what I have, and where I think it stops being reliable. Asking about multiplicity directly, because I have read four threads on it and each answered…		2	60k	11mo
Second pass at: Import rules for personal quantities, by jurisdiction, dated Sourcing › Regulatory research use only personal import FDA MHRA Second pass at: Import rules for personal quantities, by jurisdiction, dated Writing it up because I had to work it out twice and would rather nobody else did. Asking what a regulator's document actually…		2	5k	11mo
Coming back to: Cross-border purchase rules within the EU Regional › European Union EMA cost per milligram personal import Cross-border purchase rules within the EU Writing it up because I had to work it out twice and would rather nobody else did. Cross-border purchase rules within — I have the observation and I do not trust my…	+12	16	2.8k	11mo
Triple agonism: additive, synergistic, or neither? Compounds › Retatrutide retatrutide effect size preprint Solved The question in the title: Triple agonism: additive, synergistic, or neither? I will give what I have already checked below so nobody repeats it. Asking about triple agonism on behalf of the question I keep…	+71	80	38k	11mo
[2026 update] Comparing documentation quality across the directory, tabulated Sourcing › Vendor reports batch & lot numbers documentation quality disputed certificate of analysis Solved Closed On the subject in the title: Comparing documentation quality across the directory, tabulated Working notes rather than a conclusion. Structured question about turnaround and what it signals. I have started…		3	18k	11mo
Revisiting: Filing a first vendor report: a worked example Sourcing › Vendor reports batch & lot numbers documentation quality third-party testing disputed On the subject in the title: Revisiting: Filing a first vendor report: a worked example Working notes rather than a conclusion. A question about Filing a first vendor that I think has a definite answer,…		2	60k	11mo
Checking someone else's arithmetic: a worked example thread Practice › Reconstitution reconstitution syringe units concentration maths worked example Checking someone else's arithmetic: a worked example thread Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+74	78	895	11mo
Revisiting: Why a compound being unapproved is not the same as being illegal to possess Sourcing › Regulatory FDA EMA compounding research use only Closed On the subject in the title: Revisiting: Why a compound being unapproved is not the same as being illegal to possess Working notes rather than a conclusion. I would like to know what people here actually do…	+76	82	52k	11mo
BPC-157: what the rodent literature actually shows, and what it does not — a second dataset Compounds › Repair & healing peptides TB-500 preprint observational data needs a source Solved On the subject in the title: BPC-157: what the rodent literature actually shows, and what it does not — a second dataset Working notes rather than a conclusion. The question about BPC-157 that I actually want…	+77	84	54k	11mo
Coming back to: Official shortage notices and what they authorise Access › Shortages FDA compounding shortage formulary Official shortage notices and what they authorise Writing it up because I had to work it out twice and would rather nobody else did. Official shortage notices — I have the observation and I do not trust my…	+85	92	5.5k	11mo