Latest topics page 35
Topics ordered by most recent activity across all 71 subcategories.
1,535 topics · page 35 of 52
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[2026 update] A certificate with no method stated: what can you conclude?
A certificate with no method stated: what can you conclude? — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to understand what this number means before I…
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2 | 82 | 11mo | |
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When a preprint is the best available evidence and we say so
When a preprint is the best available evidence and we say so — that is the question, and I have not found it answered plainly anywhere I have looked. A preprint question rather than a question about the…
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+148 | 160 | 31k | 11mo |
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Coming back to: Sample size calculations, read backwards from the published number
On the subject in the title: Sample size calculations, read backwards from the published number Working notes rather than a conclusion. Sample size calculations — I have the observation and I do not trust my…
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+82 | 88 | 1.8k | 11mo |
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Why a pen's dose steps are fixed and what that costs you — one year on
Asking directly, because I could not find a straight answer: Why a pen's dose steps are fixed and what that costs you — one year on Question about a metering device rather than about a syringe, because the…
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+30 | 34 | 2.9k | 11mo |
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[2026 update] What we do not know about retatrutide, listed explicitly
What we do not know about retatrutide, listed explicitly — that is the question, and I have not found it answered plainly anywhere I have looked. Putting the numbers in the first post, because a question…
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+79 | 83 | 952 | 11mo |
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Tag proliferation and whether we should prune
On the subject in the title: Tag proliferation and whether we should prune Working notes rather than a conclusion. I have spent a fortnight trying to pin tag proliferation down and I want to set out where I…
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2 | 11k | 11mo | |
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Journal club: STEP-HFpEF and symptom endpoints
Journal club: STEP-HFpEF and symptom endpoints — setting out what I have, and where I think it stops being reliable. The question about step-hfpef and symptom endpoints that I actually want answered is the…
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+18 | 22 | 2.5k | 11mo |
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Revisiting: Filter needles: when they help and what they cost you
Revisiting: Filter needles: when they help and what they cost you — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on Filter needles,…
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+48 | 52 | 6.6k | 11mo |
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An emergency department visit, described afterwards
An emergency department visit, described afterwards Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers on emergency…
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+56 | 62 | 1.4k | 11mo |
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The CagriSema phase 2 paper and what a fixed combination buys
Posting this under the heading it deserves: The CagriSema phase 2 paper and what a fixed combination buys Everything below is what sits behind that. Working notes on cagrisema phase 2 paper rather than a…
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+88 | 93 | 29k | 11mo |
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SURMOUNT-4 and what withdrawal data does and does not tell an individual
SURMOUNT-4 and what withdrawal data does and does not tell an individual — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on…
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4 | 42k | 11mo | |
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Asking about a compound your prescriber has not heard of
Asking about a compound your prescriber has not heard of Writing it up because I had to work it out twice and would rather nobody else did. A question about how to describe something to a clinician rather…
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+137 | 148 | 15k | 11mo |
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Risk-of-bias tools and the judgement they conceal
Risk-of-bias tools and the judgement they conceal Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin risk-of-bias tools down and I want…
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+8 | 12 | 21k | 11mo |
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Are there stupid questions here? A staff answer, at length
Are there stupid questions here? A staff answer, at length I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title and the context underneath, in the…
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+125 | 153 | 50k | 11mo |
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Appeal templates and why they are deliberately unemotional — one year on
Appeal templates and why they are deliberately unemotional — one year on Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Appeal templates,…
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2 | 4.1k | 11mo | |
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Second pass at: Why this subcategory is stricter about sourcing than most
Second pass at: Why this subcategory is stricter about sourcing than most — setting out what I have, and where I think it stops being reliable. A comparison question rather than a question about one compound.…
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+120 | 129 | 61k | 11mo |
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Criticising the method without criticising the authors — one year on
On the subject in the title: Criticising the method without criticising the authors — one year on Working notes rather than a conclusion. A methods question rather than a substantive one, about Criticising…
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+16 | 20 | 61k | 11mo |
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Vagal afferents and the gut-brain pathway — one year on
Vagal afferents and the gut-brain pathway — one year on Writing it up because I had to work it out twice and would rather nobody else did. An honest uncertainty about Vagal afferents rather than a disguised…
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2 | 136 | 11mo | |
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Confounding by indication, explained with a concrete example
On the subject in the title: Confounding by indication, explained with a concrete example Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-2 ( N Engl J Med ,…
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+21 | 25 | 21k | 11mo |
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Follow-up: What is genuinely unknown about long-term amylin agonism
What is genuinely unknown about long-term amylin agonism I have a specific reason for asking rather than idle curiosity, and the context is below. Putting the numbers in the first post, because a question…
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2 | 25k | 11mo | |
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System suitability injections: if they failed, the run did not happen
Posting this under the heading it deserves: System suitability injections: if they failed, the run did not happen Everything below is what sits behind that. Proposing that system suitability injections…
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+23 | 27 | 6k | 11mo |
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A friction point in the promotion workflow
A friction point in the promotion workflow — setting out what I have, and where I think it stops being reliable. Asking about friction point directly, because I have read four threads on it and each answered…
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+4 | 8 | 491 | 11mo |
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MALDI versus ESI for a quick identity check
On the subject in the title: MALDI versus ESI for a quick identity check Working notes rather than a conclusion. I was wrong about MALDI versus ESI in a thread last spring and I would like to correct it…
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2 | 2k | 11mo | |
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Distinguishing a deletion sequence by mass alone — the long version
On the subject in the title: Distinguishing a deletion sequence by mass alone — the long version Working notes rather than a conclusion. A narrow question about Distinguishing a deletion sequence,…
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+38 | 44 | 60k | 11mo |
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Coming back to: Checking someone else's arithmetic: a worked example thread
Posting this under the heading it deserves: Checking someone else's arithmetic: a worked example thread Everything below is what sits behind that. Practical question with the units stated, because I have seen…
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+13 | 17 | 293 | 11mo |
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When a tidy document is a signal and when it is decoration — does this still hold?
Asking directly, because I could not find a straight answer: When a tidy document is a signal and when it is decoration — does this still hold? Tidy document keeps being re-asked here and I think that is…
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+3 | 7 | 22k | 11mo |
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Enforcement priorities versus written rules — does this still hold?
Enforcement priorities versus written rules — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Asking what a regulator's document actually says,…
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+36 | 40 | 37k | 11mo |
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EU-wide position versus national implementation
EU-wide position versus national implementation Writing it up because I had to work it out twice and would rather nobody else did. Eu-wide position versus national implementation: what I expected, what I…
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+22 | 29 | 356 | 11mo |
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Immortal time bias in a claims-database study
Immortal time bias in a claims-database study — setting out what I have, and where I think it stops being reliable. Asking about immortal time bias directly, because I have read four threads on it and each…
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+29 | 34 | 28k | 11mo |
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Comparing the STEP programme populations: who was actually enrolled — the long version
On the subject in the title: Comparing the STEP programme populations: who was actually enrolled — the long version Working notes rather than a conclusion. A narrow question about Comparing the STEP programme…
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4 | 7.7k | 11mo |