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1,535 topics · page 33 of 40

Topic	Participants	Replies	Views	Activity
Follow-up: Tracking intake honestly when appetite is absent Nutrition & Training › Protein & intake constipation micronutrients lean mass loss fatigue Solved Tracking intake honestly when appetite is absent Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Tracking intake that I did not know to ask the…	+94	106	1.8k	13mo
High-resolution MS on aggregates and what it can see Analytics › Mass spectrometry charge states counter-ion content high-resolution MS Posting this under the heading it deserves: High-resolution MS on aggregates and what it can see Everything below is what sits behind that. Something about high-resolution does not reconcile and I would like…	+117	123	6.5k	8mo
Research-use-only labelling: what it means and what it does not Sourcing › Regulatory compounding research use only EMA FDA Posting this under the heading it deserves: Research-use-only labelling: what it means and what it does not Everything below is what sits behind that. A labelling question, and I would like the answer to be…	+100	110	37k	5mo
Realistic expectations for strength while losing weight quickly Nutrition & Training › Resistance training fatigue DXA lean mass loss Closed Posting this under the heading it deserves: Realistic expectations for strength while losing weight quickly Everything below is what sits behind that. Working notes on realistic expectations for strength…	+60	70	38k	4mo
"Should I double up?" — answered once, at length, calmly Practice › Administration subcutaneous injection missed dose injection site reaction "Should I double up?" — answered once, at length, calmly — setting out what I have, and where I think it stops being reliable. A practical question that I suspect has a boring answer, which is why I could not…	+24	28	13k	9mo
Follow-up: Retatrutide phase 2 in type 2 diabetes: the Lancet paper Compounds › Retatrutide retatrutide effect size TRIUMPH programme preprint Retatrutide phase 2 in type 2 diabetes: the Lancet paper Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Retatrutide phase 2 in type that I did…	+1	5	31k	8mo
Sodium, potassium and magnesium when intake drops Nutrition & Training › Hydration & electrolytes blood pressure heart rate fatigue Solved On the subject in the title: Sodium, potassium and magnesium when intake drops Working notes rather than a conclusion. A hydration and intake question, with the figures, since this one is unanswerable without…	+73	78	56k	12mo
Reconciling a label claim with a content assay Analytics › COA interpretation documentation quality amino acid analysis reference standards certificate of analysis Closed On the subject in the title: Reconciling a label claim with a content assay Working notes rather than a conclusion. The question about reconciling a label claim that I actually want answered is the second one…	+2	6	183	4mo
Merging two pages that cover the same ground Documentation › Wiki requests wiki post promoted to docs maintainership Merging two pages that cover the same ground Writing it up because I had to work it out twice and would rather nobody else did. Process question, and I have read the guidelines before asking. I understand the…		2	888	13mo
About the European Union category Regional › European Union EMA personal import cost per milligram Pinned Wiki Closed EMA positions, national differences within the EU, and cross-border purchase rules. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…	+1	5	18k	10mo
What the GIP component of tirzepatide is thought to contribute, and how confident we can be — the long version Compounds › Tirzepatide SURMOUNT programme randomised trial effect size tirzepatide Solved Asking directly, because I could not find a straight answer: What the GIP component of tirzepatide is thought to contribute, and how confident we can be — the long version A narrow question about GIP…	+48	52	609	10mo
Coming back to: When "no data" is the complete and final answer Compounds › Other compounds research use only needs a source custom synthesis When "no data" is the complete and final answer I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about the compound itself rather than about a trial of it. I…	+77	82	12k	11mo
Tracking that stops updating and then resumes Sourcing › Logistics customs temperature excursion cold chain shipping Solved On the subject in the title: Tracking that stops updating and then resumes Working notes rather than a conclusion. A logistics question, since the answers here are usually better than anywhere else I have…	+58	62	1.9k	7mo
Second pass at: Trial registration and comparing the protocol with the paper Evidence › Trials estimand discontinuation & dropout randomised trial open label Posting this under the heading it deserves: Second pass at: Trial registration and comparing the protocol with the paper Everything below is what sits behind that. Two things I would like separated before…	+30	34	33k	13mo
Pre-registering a personal experiment, seriously Research Methods › N-of-1 designs worked example data table effect size confounding Pre-registering a personal experiment, seriously — setting out what I have, and where I think it stops being reliable. A narrow question about pre-registering a personal experiment, deliberately narrow,…	+96	119	58k	14mo
Coming back to: Getting a referral rather than a refusal Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes beginner friendly Solved Posting this under the heading it deserves: Getting a referral rather than a refusal Everything below is what sits behind that. Working notes on Getting a referral rather than a conclusion. I would rather…	+69	74	1.7k	13mo
Revisiting: Reading a denial letter as a specification for your appeal Access › Insurance & coverage prior authorisation insurance formulary appeals Posting this under the heading it deserves: Revisiting: Reading a denial letter as a specification for your appeal Everything below is what sits behind that. Asking about Reading a denial letter on behalf of…	+125	138	9.4k	10mo
A comparison of home results against a laboratory result on the same vial Analytics › Home & field testing documentation quality ELISA third-party testing Posting this under the heading it deserves: A comparison of home results against a laboratory result on the same vial Everything below is what sits behind that. Comparison of home results against: setting out…	+61	65	35k	8mo
Price changes over 2025 and 2026, tabulated and dated Access › Pricing formulary cost per milligram data table compounding Posting this under the heading it deserves: Price changes over 2025 and 2026, tabulated and dated Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this…	+4	8	658	14mo
What I would record differently if I started again — the long version Outcomes › Progress reports effect size data table DXA Solved Closed What I would record differently if I started again — the long version I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about the phase almost nobody writes…	+22	26	57k	5mo
Detection wavelength and why 214 nm and 280 nm disagree Analytics › HPLC & UHPLC peak integration UV & DAD detection system suitability HPLC On the subject in the title: Detection wavelength and why 214 nm and 280 nm disagree Working notes rather than a conclusion. I would like to disagree carefully with the settled view on detection wavelength,…	+78	84	1.7k	8mo
Consistent declarations and why they matter more than clever ones — a second dataset Sourcing › Logistics customs cold chain packaging shipping Solved On the subject in the title: Consistent declarations and why they matter more than clever ones — a second dataset Working notes rather than a conclusion. Posting a small dataset on Consistent declarations. It…		2	4.1k	13mo
Gauge and length selection for subcutaneous injection Devices › Syringes & needles syringe units needle gauge & length worked example subcutaneous injection Solved Gauge and length selection for subcutaneous injection Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about gauge and length selection that I did not…	+50	55	1.3k	8mo
Needle changes between doses on a reusable pen — does this still hold? Devices › Pens & autoinjectors dead volume missed dose storage Solved Wiki Needle changes between doses on a reusable pen — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Posting a small dataset on Needle changes…	+1	5	38k	13mo
Follow-up: Glucagon receptor agonism in a weight-loss compound Pharmacology › Receptor biology amylin analogues long read tirzepatide retatrutide Glucagon receptor agonism in a weight-loss compound Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Glucagon receptor agonism that I did not know…	+5	9	21k	7mo
About the Logistics category Sourcing › Logistics shipping customs packaging Pinned Wiki Shipping, tracking, customs outcomes, packaging, and cold-chain handling in transit. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…	+1	5	9.2k	12mo
Forced degradation studies: designing one that is informative — does this still hold? Analytics › Method validation stability-indicating method precision & repeatability LOD & LOQ system suitability Solved The question in the title: Forced degradation studies: designing one that is informative — does this still hold? I will give what I have already checked below so nobody repeats it. The question about Forced…	+37	41	1.2k	12mo
[2026 update] Constipation management, with a dietitian's contribution Practice › Side effects nausea vomiting delayed gastric emptying hair shedding Constipation management, with a dietitian's contribution — setting out what I have, and where I think it stops being reliable. Constipation management: what I expected, what I found, and the gap between them.…	+6	10	812	12mo
Revisiting: GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Revisiting: GLP-1 receptor distribution: central and peripheral — setting out what I have, and where I think it stops being reliable. An honest uncertainty about GLP-1 receptor distribution rather than a…	+61	66	15k	8mo
Substitution between formats during a shortage Access › Shortages compounding FDA formulary shortage Solved Closed On the subject in the title: Substitution between formats during a shortage Working notes rather than a conclusion. The question about substitution between formats that I actually want answered is the second…	+114	123	47k	7mo