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1,535 topics · page 34 of 40

Topic	Participants	Replies	Views	Activity
Second pass at: Two scans six weeks apart on different machines: a cautionary tale Outcomes › Body composition DXA bioimpedance lean mass loss data table Second pass at: Two scans six weeks apart on different machines: a cautionary tale Writing it up because I had to work it out twice and would rather nobody else did. A question about measurement precision…	+1	5	34k	8mo
Half-life, steady state, and accumulation worked through Pharmacology › Pharmacokinetics semaglutide liraglutide tirzepatide Wiki Half-life, steady state, and accumulation worked through Writing it up because I had to work it out twice and would rather nobody else did. Working through the kinetics rather than the pharmacology, because I…	+115	130	44k	13mo
Coming back to: Semaglutide half-life: where the 165 to 184 hour figure comes from Compounds › Semaglutide SELECT trial type 2 diabetes semaglutide Semaglutide half-life: where the 165 to 184 hour figure comes from Writing it up because I had to work it out twice and would rather nobody else did. Putting the numbers in the first post, because a question…	+112	119	3.3k	11mo
Travel coolers and how long they really hold — the long version Devices › Cold chain storage freeze-thaw cold chain Solved Pinned Travel coolers and how long they really hold — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Travel coolers, deliberately narrow, because the…	+19	23	45k	14mo
Biological variation versus analytical imprecision Clinical › Bloodwork lipase & amylase liver enzymes thyroid function HbA1c On the subject in the title: Biological variation versus analytical imprecision Working notes rather than a conclusion. A question about biological variation versus analytical imprecision that I think has a…		2	42k	12mo
Titrating on tolerability rather than on the calendar Practice › Dosing & titration dose reduction tirzepatide worked example missed dose On the subject in the title: Titrating on tolerability rather than on the calendar Working notes rather than a conclusion. An honest uncertainty about titrating on tolerability rather than a disguised…		2	31k	13mo
About the Contraindications category Safety › Contraindications thyroid C-cell question pancreatitis pregnancy & planning Pinned Wiki Absolute and relative contraindications, and the conditions that change the calculus. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+6	10	35k	14mo
Pregnancy as an absolute contraindication Safety › Contraindications disordered eating delayed gastric emptying pregnancy & planning pancreatitis Solved Pregnancy as an absolute contraindication — setting out what I have, and where I think it stops being reliable. Pregnancy keeps being re-asked here and I think that is because the answer is conditional and…	+102	106	21k	14mo
Second pass at: Designing a personal experiment that could change your mind Research Methods › N-of-1 designs worked example effect size confounding data table Solved Second pass at: Designing a personal experiment that could change your mind Writing it up because I had to work it out twice and would rather nobody else did. The question about Designing a personal…	+39	44	632	14mo
Lipase elevation without symptoms: the interpretation problem — a second dataset Clinical › Bloodwork lipid panel liver enzymes HbA1c eGFR & renal function Wiki Closed Posting this under the heading it deserves: Lipase elevation without symptoms: the interpretation problem — a second dataset Everything below is what sits behind that. Posting a small dataset on Lipase…	+6	15	2.2k	13mo
Specification in the result column: why that is a meaningful error Analytics › COA interpretation reference standards amino acid analysis certificate of analysis batch & lot numbers Under review Closed Posting this under the heading it deserves: Specification in the result column: why that is a meaningful error Everything below is what sits behind that. A documentation question rather than an analytical…	+107	129	41k	5mo
Follow-up: The decimal-point error, and the habit that catches it Practice › Reconstitution concentration maths bacteriostatic water dead volume reconstitution Closed On the subject in the title: The decimal-point error, and the habit that catches it Working notes rather than a conclusion. A follow-up question about decimal-point error that I did not know to ask the first…	+118	131	50k	7mo
[2026 update] Clearance pathways and what renal impairment changes Pharmacology › Pharmacokinetics missed dose liraglutide worked example Solved On the subject in the title: Clearance pathways and what renal impairment changes Working notes rather than a conclusion. What changes if the standard account of Clearance pathways is wrong? I ask because I…	+63	69	50k	13mo
Meeting a protein target on a suppressed appetite Nutrition & Training › Protein & intake constipation micronutrients lean mass loss fatigue Meeting a protein target on a suppressed appetite Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin meeting a protein target down and I…	+39	44	11k	7mo
Regional warehouse stock versus direct despatch Sourcing › Logistics customs cold chain shipping Posting this under the heading it deserves: Regional warehouse stock versus direct despatch Everything below is what sits behind that. Asking about regional warehouse stock versus direct on behalf of the…	+8	12	171	10mo
Reading a regulatory notice rather than an article about it — what changed since Sourcing › Regulatory research use only MHRA FDA personal import Reading a regulatory notice rather than an article about it — what changed since — setting out what I have, and where I think it stops being reliable. Asking what a regulator's document actually says, since…	+28	32	640	13mo
BPC-157: what the rodent literature actually shows, and what it does not Compounds › Repair & healing peptides observational data preprint BPC-157 needs a source BPC-157: what the rodent literature actually shows, and what it does not — setting out what I have, and where I think it stops being reliable. I would like to know what people here actually do about BPC-157,…	+44	48	3k	10mo
Request: a diff view for wiki revisions — the long version Meta › Feature requests translation site feedback wiki post Solved Posting this under the heading it deserves: Request: a diff view for wiki revisions — the long version Everything below is what sits behind that. A narrow question about diff view for wiki revisions,…	+92	104	61k	6mo
Comparators chosen for regulatory reasons rather than clinical ones Evidence › Trials surrogate endpoints open label estimand randomised trial Pinned Closed On the subject in the title: Comparators chosen for regulatory reasons rather than clinical ones Working notes rather than a conclusion. An honest uncertainty about comparators chosen for regulatory reasons…		2	27k	14mo
The storage lookup and where its data comes from Data & Tools › Calculators worked example site feedback syringe units concentration maths Solved Closed The storage lookup and where its data comes from — setting out what I have, and where I think it stops being reliable. Working notes on storage lookup rather than a conclusion. I would rather post the…	+4	8	4.1k	11mo
Journal club: the CagriSema phase 2 combination paper — a second dataset Evidence › Journal club journal club estimand effect size Solved Journal club: the CagriSema phase 2 combination paper — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on CagriSema phase 2 combination paper.…	+74	79	2.3k	13mo
System suitability injections: if they failed, the run did not happen Analytics › HPLC & UHPLC peak integration HPLC data table gradient method Posting this under the heading it deserves: System suitability injections: if they failed, the run did not happen Everything below is what sits behind that. Proposing that system suitability injections…	+23	27	6k	11mo
Revisiting: Filing a first vendor report: a worked example Sourcing › Vendor reports batch & lot numbers documentation quality third-party testing disputed On the subject in the title: Revisiting: Filing a first vendor report: a worked example Working notes rather than a conclusion. A question about Filing a first vendor that I think has a definite answer,…		2	60k	11mo
Coming back to: What happens when a maintainer goes quiet Documentation › Doc review promoted to docs citation check review date wiki post Asking directly, because I could not find a straight answer: What happens when a maintainer goes quiet Nomination for promotion into the documentation commons, with the criteria addressed one by one. The…	+6	10	400	10mo
How the vendor documentation pages are maintained, and by whom — what changed since Sourcing › Vendor reports third-party testing disputed batch & lot numbers Solved Asking directly, because I could not find a straight answer: How the vendor documentation pages are maintained, and by whom — what changed since What changes if the standard account of vendor documentation…	+98	104	3k	8mo
Promotion criteria, and the one that stops most nominations — the long version Documentation › Doc review promoted to docs maintainership citation check wiki post On the subject in the title: Promotion criteria, and the one that stops most nominations — the long version Working notes rather than a conclusion. A narrow question about Promotion criteria, deliberately…	+130	143	7.2k	6mo
Second pass at: Semaglutide and alcohol: what is actually documented Compounds › Semaglutide semaglutide type 2 diabetes effect size randomised trial Closed Second pass at: Semaglutide and alcohol: what is actually documented Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers…	+15	19	4.4k	13mo
Follow-up: Why the titration planner refuses to produce a schedule below a floor Data & Tools › Calculators worked example syringe units site feedback The question in the title: Why the titration planner refuses to produce a schedule below a floor I will give what I have already checked below so nobody repeats it. A follow-up question about titration…	+120	146	14k	10mo
Coming back to: The SOUL trial and oral semaglutide cardiovascular outcomes Compounds › Oral incretins randomised trial SOUL trial oral semaglutide orforglipron Solved The SOUL trial and oral semaglutide cardiovascular outcomes — setting out what I have, and where I think it stops being reliable. SOUL trial and oral semaglutide — I have the observation and I do not trust my…	+100	104	4.2k	5mo
Revisiting: Why a compound being unapproved is not the same as being illegal to possess Sourcing › Regulatory FDA EMA compounding research use only Closed On the subject in the title: Revisiting: Why a compound being unapproved is not the same as being illegal to possess Working notes rather than a conclusion. I would like to know what people here actually do…	+76	82	52k	11mo