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New topics page 8

Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 8 of 40

Topic	Participants	Replies	Views	Activity
Adolescents: a distinct evidence base Clinical › Special populations older adults pregnancy & planning adolescents chronic kidney disease Adolescents: a distinct evidence base Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of adolescents is wrong? I ask because I have been…		3	11k	9h
HbA1c lag and what it can and cannot tell you at eight weeks — one year on Clinical › Bloodwork liver enzymes lipase & amylase lipid panel thyroid function Posting this under the heading it deserves: HbA1c lag and what it can and cannot tell you at eight weeks — one year on Everything below is what sits behind that. A methods question rather than a substantive…	+18	22	655	13h
Electrolyte supplements: which ones do anything Nutrition & Training › Hydration & electrolytes blood pressure heart rate fatigue Solved On the subject in the title: Electrolyte supplements: which ones do anything Working notes rather than a conclusion. A hydration and intake question, with the figures, since this one is unanswerable without…	+47	51	31k	18d
What a confidence interval means, from scratch Research Methods › Statistics number needed to treat confounding worked example heterogeneity What a confidence interval means, from scratch — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about confidence interval directly, because I have read four…		2	2.6k	2mo
Revisiting: A field-by-field walk through a certificate of analysis Analytics › COA interpretation certificate of analysis documentation quality reference standards amino acid analysis Revisiting: A field-by-field walk through a certificate of analysis Writing it up because I had to work it out twice and would rather nobody else did. I would like to disagree carefully with the settled view…	+37	41	656	3mo
A revision dispute resolved on the topic rather than in the history Meta › Wiki maintenance wiki post maintainership moderation citation check A revision dispute resolved on the topic rather than in the history Writing it up because I had to work it out twice and would rather nobody else did. Proposing that revision dispute resolved deserves a…	+10	15	40k	16h
Semaglutide and alcohol: what is actually documented Compounds › Semaglutide STEP programme randomised trial type 2 diabetes SELECT trial Posting this under the heading it deserves: Semaglutide and alcohol: what is actually documented Everything below is what sits behind that. I would like to know what people here actually do about semaglutide…	+14	18	10k	2d
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just differently reported? Compounds › Tirzepatide tirzepatide SURMOUNT programme effect size randomised trial Solved Tirzepatide and nausea: is the profile genuinely different or just differently reported? I have a specific reason for asking rather than idle curiosity, and the context is below. Something about Tirzepatide…	+109	122	3.6k	2mo
An appeal that succeeded, with the letter structure Access › Insurance & coverage appeals formulary prior authorisation insurance On the subject in the title: An appeal that succeeded, with the letter structure Working notes rather than a conclusion. Appeal, and specifically the version of it that the documentation does not cover. The…	+12	16	15k	1d
Why 99.2% and 97.8% on the same lot can both be correct Analytics › HPLC & UHPLC system suitability peak integration gradient method data table Solved Why 99.2% and 97.8% on the same lot can both be correct I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means before I…	+16	20	3.1k	11h
How much of the diluent volume the powder itself displaces Practice › Reconstitution concentration maths bacteriostatic water dead volume worked example Asking directly, because I could not find a straight answer: How much of the diluent volume the powder itself displaces Writing this out with the numbers in it, because "roughly" is how these go wrong. Vial:…		2	1.8k	1d
Coming back to: A structured critique template this community uses Evidence › Study critique confounding risk of bias disputed observational data Posting this under the heading it deserves: A structured critique template this community uses Everything below is what sits behind that. Reading back through what has been written here about structured…	+63	69	17k	18h
Journal club: SELECT, absolute risk, and how it was reported Evidence › Journal club journal club estimand randomised trial effect size Journal club: SELECT, absolute risk, and how it was reported Writing it up because I had to work it out twice and would rather nobody else did. A question about what the numbers mean rather than what they…		2	52k	1mo
Batch numbers that do not match the vial label — what changed since Sourcing › Red flags underdosing documentation quality disputed moderation Solved On the subject in the title: Batch numbers that do not match the vial label — what changed since Working notes rather than a conclusion. What changes if the standard account of Batch numbers is wrong? I ask…	+39	43	14k	1mo
Risk-of-bias tools and the judgement they conceal — does this still hold? Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Solved Risk-of-bias tools and the judgement they conceal — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about Risk-of-bias tools on behalf of…	+26	30	5.8k	23h
Talking to a therapist about this specifically Wellbeing › Mental health disordered eating beginner friendly mood Solved Posting this under the heading it deserves: Talking to a therapist about this specifically Everything below is what sits behind that. Something that has come up for me and that I suspect is more common than…	+20	24	855	14h
Delayed gastric emptying and oral medication absorption: which drugs matter — one year on Practice › Interactions needs a source delayed gastric emptying hypoglycaemia insulin Solved Closed On the subject in the title: Delayed gastric emptying and oral medication absorption: which drugs matter — one year on Working notes rather than a conclusion. A follow-up question about Delayed gastric…		3	16k	2mo
What I would want from a home test that does not exist yet — what changed since Analytics › Home & field testing third-party testing LOD & LOQ documentation quality ELISA Solved Asking directly, because I could not find a straight answer: What I would want from a home test that does not exist yet — what changed since Two reports on the same lot, and I would like help deciding whether…	+101	111	1.9k	21h
Packaging that arrived damaged: documenting it properly Sourcing › Logistics shipping customs temperature excursion cold chain Pinned Packaging that arrived damaged: documenting it properly Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than…	+43	49	26k	1d
Follow-up: A parcel that arrived warm: a decision process, not a verdict Practice › Storage & stability temperature excursion cloudy or discoloured solution beyond-use date Posting this under the heading it deserves: A parcel that arrived warm: a decision process, not a verdict Everything below is what sits behind that. Asking about the failure mode rather than the procedure,…	+49	59	1.2k	2mo
Private prescribing in the UK: what is actually involved Regional › UK & Ireland personal import cost per milligram MHRA Pinned On the subject in the title: Private prescribing in the UK: what is actually involved Working notes rather than a conclusion. The question about private prescribing that I actually want answered is the second…	+66	76	46k	14h
Hair shedding at month three: mechanism and time course — the long version Practice › Side effects nausea delayed gastric emptying vomiting Hair shedding at month three: mechanism and time course — the long version Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here…	+50	54	50k	1d
Coming back to: Measurement error in a self-reported exposure Evidence › Study critique risk of bias observational data effect size disputed Measurement error in a self-reported exposure — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about Measurement error, three questions…	+23	27	49k	3mo
An 18-month record including the parts that went badly Outcomes › Progress reports data table long read effect size DXA An 18-month record including the parts that went badly — setting out what I have, and where I think it stops being reliable. Asking about 18-month record on behalf of the question I keep seeing asked badly,…	+77	81	17k	12h
Endotoxin and why it is a separate question from purity — what changed since Analytics › Impurities & related substances HPLC endotoxin testing data table forced degradation On the subject in the title: Endotoxin and why it is a separate question from purity — what changed since Working notes rather than a conclusion. What changes if the standard account of Endotoxin is wrong? I…	+78	91	1k	10h
Coming back to: Specificity, linearity, accuracy, precision, range, robustness — with real criteria Analytics › Method validation linearity recovery precision & repeatability system suitability On the subject in the title: Specificity, linearity, accuracy, precision, range, robustness — with real criteria Working notes rather than a conclusion. Trying to establish the boundary conditions on…	+93	99	1.4k	6d
Converting between mg/mL and units per dose, both directions — the long version Practice › Reconstitution reconstitution worked example syringe units dead volume Converting between mg/mL and units per dose, both directions — the long version Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated,…	+110	132	1.7k	3mo
Fatigue in the first month: how much is the drug and how much is intake Practice › Side effects vomiting fatigue constipation Solved On the subject in the title: Fatigue in the first month: how much is the drug and how much is intake Working notes rather than a conclusion. Something changed and I would like to know whether it should have.…		4	17k	3mo
Subgroup analyses: pre-specified versus discovered Evidence › Trials randomised trial intention to treat surrogate endpoints estimand Subgroup analyses: pre-specified versus discovered — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on subgroup analyses, and I…		2	27k	1d
Revisiting: What pooling buys you and what it destroys Evidence › Meta-analyses heterogeneity effect size publication bias Solved On the subject in the title: Revisiting: What pooling buys you and what it destroys Working notes rather than a conclusion. Pooling buys — I have the observation and I do not trust my interpretation of it, so…	+97	107	4k	19h