Ranked by engagement

Top topics — all time page 3

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 3 of 40

Topic	Participants	Replies	Views	Activity
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Evidence › Journal club estimand randomised trial number needed to treat effect size Journal club: SURPASS-2 and the semaglutide 1 mg comparator Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-4 ( Lancet , 2021). Please read it before…	+126	138	31k	17mo
Reading a trial's population section before its results — does this still hold? Evidence › Trials randomised trial open label intention to treat discontinuation & dropout Closed Reading a trial's population section before its results — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen STEP 1 ( N Engl J Med ,…	+140	154	5.4k	14mo
Managing an unplanned gap in supply — what changed since Access › Shortages compounding FDA formulary On the subject in the title: Managing an unplanned gap in supply — what changed since Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…	+114	124	54k	8mo
A supplier that answers analytical questions with restated claims Sourcing › Red flags documentation quality disputed moderation mislabelling Solved Wiki On the subject in the title: A supplier that answers analytical questions with restated claims Working notes rather than a conclusion. A logistics question, since the answers here are usually better than…	+107	118	45k	12mo
Biased agonism: a real phenomenon, an over-used explanation Pharmacology › Receptor biology semaglutide retatrutide long read tirzepatide Posting this under the heading it deserves: Biased agonism: a real phenomenon, an over-used explanation Everything below is what sits behind that. A documentation question rather than an analytical one. I…	+130	135	23k	16mo
Promotion criteria, and the one that stops most nominations Documentation › Doc review citation check review date wiki post promoted to docs Closed Promotion criteria, and the one that stops most nominations — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic…	+135	146	17k	19mo
Adjudicated events and why the definition matters — the long version Evidence › Trials intention to treat estimand randomised trial discontinuation & dropout Adjudicated events and why the definition matters — the long version Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with STEP 4 ( JAMA…	+125	146	13k	15mo
Tracking a preprint to publication: a worked example Evidence › Preprints preprint risk of bias needs a source Tracking a preprint to publication: a worked example Writing it up because I had to work it out twice and would rather nobody else did. Session topic: STEP 1 ( N Engl J Med , 2021). Please read it before…	+133	147	15k	7mo
Seven-day rolling means and why weekly readings mislead Outcomes › Progress reports data table DXA effect size long read Seven-day rolling means and why weekly readings mislead Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this that almost…	+109	125	42k	10h
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Practice › Reconstitution concentration maths bacteriostatic water syringe units On the subject in the title: A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Working notes rather than a conclusion. Reporting something rather than asking about it, in case the…	+160	165	1.9k	12mo
Charge states for a 4 kDa peptide, worked through Analytics › Mass spectrometry high-resolution MS counter-ion content charge states LC-MS Solved On the subject in the title: Charge states for a 4 kDa peptide, worked through Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. retatrutide has a…	+124	146	15k	16mo
A ten-fold dose error caught before injection — one year on Devices › Syringes & needles dead volume needle gauge & length subcutaneous injection syringe units On the subject in the title: A ten-fold dose error caught before injection — one year on Working notes rather than a conclusion. A question about technique rather than about dose. I have been doing the same…	+151	157	9.4k	12mo
Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions metformin needs a source hypoglycaemia Solved Wiki On the subject in the title: Delayed gastric emptying and oral medication absorption: which drugs matter Working notes rather than a conclusion. Reporting something rather than asking about it, in case the…	+110	116	43k	14mo
Trifluoroacetate content and its consequences Analytics › Impurities & related substances water content data table forced degradation counter-ion content Trifluoroacetate content and its consequences — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in front of me…	+123	134	31k	5mo
Racemisation and why it is invisible to a mass measurement Analytics › Impurities & related substances counter-ion content endotoxin testing HPLC Closed Posting this under the heading it deserves: Racemisation and why it is invisible to a mass measurement Everything below is what sits behind that. Working through the identity arithmetic and I would like it…	+120	127	41k	1mo
Request: a diff view for wiki revisions — the long version Meta › Feature requests translation site feedback wiki post Solved Posting this under the heading it deserves: Request: a diff view for wiki revisions — the long version Everything below is what sits behind that. Process question about how this site works. I have read the…	+96	104	61k	6mo
Substitution between formats during a shortage Access › Shortages compounding FDA formulary shortage Solved Closed On the subject in the title: Substitution between formats during a shortage Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As of…	+114	123	47k	7mo
[2026 update] What steady state means for the decision to escalate Practice › Dosing & titration tirzepatide worked example semaglutide missed dose The question in the title: What steady state means for the decision to escalate I will give what I have already checked below so nobody repeats it. I have read the maintained page on this and I still have a…	+127	137	32k	8mo
A reconstituted vial's beyond-use date and the reasoning behind common figures Practice › Storage & stability temperature excursion storage freeze-thaw Posting this under the heading it deserves: A reconstituted vial's beyond-use date and the reasoning behind common figures Everything below is what sits behind that. Practical question with the units stated,…	+125	129	45k	2mo
Reconstituting a multi-strength kit without mixing yourself up Practice › Reconstitution reconstitution concentration maths syringe units Wiki Reconstituting a multi-strength kit without mixing yourself up Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen…	+108	123	30k	11mo
Follow-up: Why the titration planner refuses to produce a schedule below a floor Data & Tools › Calculators worked example syringe units site feedback The question in the title: Why the titration planner refuses to produce a schedule below a floor I will give what I have already checked below so nobody repeats it. I would like to understand what this number…	+120	146	14k	10mo
Thyroid function tests during substantial weight change Clinical › Bloodwork lipase & amylase HbA1c liver enzymes eGFR & renal function Closed Posting this under the heading it deserves: Thyroid function tests during substantial weight change Everything below is what sits behind that. General question, not a request for advice about my own care — I…	+136	149	3.3k	8mo
[2026 update] Charge states for a 4 kDa peptide, worked through Analytics › Mass spectrometry counter-ion content MALDI-TOF high-resolution MS LC-MS On the subject in the title: Charge states for a 4 kDa peptide, worked through Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. semaglutide has a…	+116	135	31k	3mo
Why we hide unevidenced fraud accusations and log the hiding Sourcing › Red flags underdosing mislabelling disputed moderation Solved Why we hide unevidenced fraud accusations and log the hiding — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to talk about documentation quality as a…	+97	106	63k	14mo
Distinguishing a deletion sequence by mass alone Analytics › Mass spectrometry mass error (ppm) high-resolution MS LC-MS MALDI-TOF Solved Distinguishing a deletion sequence by mass alone Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+121	129	25k	17mo
Micro-titration: a disputed topic, argued properly Practice › Dosing & titration titration dose reduction worked example tirzepatide Solved Wiki Micro-titration: a disputed topic, argued properly Writing it up because I had to work it out twice and would rather nobody else did. A question about technique rather than about dose. I have been doing the…	+99	110	61k	2d
Revisiting: Melanocortin agonists: mechanism and the documented adverse profile Compounds › Other compounds custom synthesis mislabelling research use only Solved Posting this under the heading it deserves: Revisiting: Melanocortin agonists: mechanism and the documented adverse profile Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with…	+119	141	22k	20mo
Counter-ion form: the field almost nobody reports — one year on Analytics › COA interpretation documentation quality reference standards batch & lot numbers On the subject in the title: Counter-ion form: the field almost nobody reports — one year on Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a…	+121	139	31k	16mo
[2026 update] What the GIP component of tirzepatide is thought to contribute, and how confident we can be Compounds › Tirzepatide SURPASS programme randomised trial effect size Under review The question in the title: What the GIP component of tirzepatide is thought to contribute, and how confident we can be I will give what I have already checked below so nobody repeats it. Comparing STEP 4 (…	+109	124	31k	10mo
[2026 update] An appeal that failed, and what I would do differently Access › Insurance & coverage prior authorisation insurance formulary Posting this under the heading it deserves: An appeal that failed, and what I would do differently Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this…	+152	159	2.5k	13mo