Ranked by engagement

Top topics — all time page 34

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 34 of 40

Topic	Participants	Replies	Views	Activity
Relative retention time as a better inter-laboratory comparator Analytics › Method validation linearity recovery precision & repeatability stability-indicating method On the subject in the title: Relative retention time as a better inter-laboratory comparator Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will…	+7	11	28k	14mo
Publication bias detection and its low power — does this still hold? Evidence › Meta-analyses publication bias risk of bias meta-analysis heterogeneity Solved The question in the title: Publication bias detection and its low power — does this still hold? I will give what I have already checked below so nobody repeats it. I have seen LEADER ( N Engl J Med , 2016)…	+24	28	2.4k	3mo
Revisiting: Taste changes and food aversion, reported and discussed Practice › Side effects nausea vomiting constipation Revisiting: Taste changes and food aversion, reported and discussed Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have…	+20	25	4.3k	1d
Why chargeback is not the safety net people assume Sourcing › Payments research use only payments documentation quality Solved Asking directly, because I could not find a straight answer: Why chargeback is not the safety net people assume A logistics question, since the answers here are usually better than anywhere else I have…	+22	26	2.5k	2d
Coming back to: Amylin analogue mechanism: satiety signalling separate from GLP-1 Compounds › Cagrilintide & amylin analogues cagrisema effect size randomised trial cagrilintide On the subject in the title: Amylin analogue mechanism: satiety signalling separate from GLP-1 Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a claim I…	+27	31	671	12mo
When to stop reading forums, including this one — the long version Wellbeing › Mental health disordered eating beginner friendly mood Solved Asking directly, because I could not find a straight answer: When to stop reading forums, including this one — the long version General question, not a request for advice about my own care — I know the…	+23	27	8.3k	14mo
Why a pen's dose steps are fixed and what that costs you — one year on Devices › Pens & autoinjectors storage subcutaneous injection missed dose Solved Closed Asking directly, because I could not find a straight answer: Why a pen's dose steps are fixed and what that costs you — one year on I have read the maintained page on this and I still have a gap, so I am…	+30	34	2.9k	11mo
How to tell whether your question is already answered on a maintained page Start Here › Welcome guidelines onboarding trust levels Solved How to tell whether your question is already answered on a maintained page — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I…	+5	9	30k	3mo
Payment mechanics and the recovery options that do not exist — what changed since Sourcing › Payments documentation quality payments research use only Solved On the subject in the title: Payment mechanics and the recovery options that do not exist — what changed since Working notes rather than a conclusion. A logistics question, since the answers here are usually…	+14	18	17k	13mo
Feature request: should a dose-equivalence tool exist at all? Data & Tools › Calculators site feedback worked example concentration maths syringe units Closed Feature request: should a dose-equivalence tool exist at all? — that is the question, and I have not found it answered plainly anywhere I have looked. Posting the method first, because I know what the first…	+21	25	4.8k	18mo
System suitability injections: if they failed, the run did not happen Analytics › HPLC & UHPLC peak integration HPLC data table gradient method Posting this under the heading it deserves: System suitability injections: if they failed, the run did not happen Everything below is what sits behind that. A documentation question rather than an analytical…	+23	27	6k	11mo
Second opinions: how to seek one without burning the first Clinical › Prescriber conversations telehealth prior authorisation beginner friendly type 2 diabetes Closed Second opinions: how to seek one without burning the first Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my own care — I…	+1	5	33k	19mo
Why catalogue breadth is not evidence of anything Compounds › Other compounds research use only needs a source custom synthesis Under review Why catalogue breadth is not evidence of anything I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I…		2	38k	2d
Second pass at: Cost versus information: making the trade-off explicitly Analytics › Home & field testing third-party testing documentation quality ELISA Posting this under the heading it deserves: Second pass at: Cost versus information: making the trade-off explicitly Everything below is what sits behind that. Working through the identity arithmetic and I…	+23	27	6.1k	22h
Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit? Compounds › Semaglutide type 2 diabetes randomised trial semaglutide SELECT trial Solved Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit? — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4 ( JAMA ,…	+5	9	30k	8d
What happens after your first post: likes, trust levels, and why none of it matters much Start Here › Welcome guidelines beginner friendly trust levels onboarding Solved Asking directly, because I could not find a straight answer: What happens after your first post: likes, trust levels, and why none of it matters much I want to check my reasoning rather than get a conclusion.…	+15	19	17k	16mo
Why our vendor pages link the storefront and mark it sponsored Sourcing › Vendor reports batch & lot numbers Janoshik Analytical certificate of analysis disputed Solved Why our vendor pages link the storefront and mark it sponsored — that is the question, and I have not found it answered plainly anywhere I have looked. A logistics question, since the answers here are usually…	+17	21	335	18mo
Follow-up: Retatrutide phase 2 in type 2 diabetes: the Lancet paper Compounds › Retatrutide retatrutide effect size TRIUMPH programme preprint Retatrutide phase 2 in type 2 diabetes: the Lancet paper Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I…	+1	5	31k	8mo
A pooled estimate that changed when one trial was added Evidence › Meta-analyses meta-analysis publication bias effect size Solved A pooled estimate that changed when one trial was added — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it before posting; the…	+24	28	3.5k	2d
Selection into a registry and what it does to the estimate — a second dataset Evidence › Study critique confounding risk of bias effect size disputed Solved Posting this under the heading it deserves: Selection into a registry and what it does to the estimate — a second dataset Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024).…	+28	32	1.3k	1d
Why we ask for units every single time, with three examples of what goes wrong — what changed since Start Here › How to Ask onboarding guidelines worked example beginner friendly The question in the title: Why we ask for units every single time, with three examples of what goes wrong — what changed since I will give what I have already checked below so nobody repeats it. Question in…	+14	18	19k	2mo
Coming back to: Why semaglutide solutions can look faintly opalescent and when that matters Compounds › Semaglutide SELECT trial randomised trial STEP programme Asking directly, because I could not find a straight answer: Why semaglutide solutions can look faintly opalescent and when that matters Comparing SELECT ( N Engl J Med , 2023) with PIONEER 6 ( N Engl J Med ,…	+16	20	17k	13mo
Follow-up: Why we hide unevidenced fraud accusations and log the hiding Sourcing › Red flags mislabelling disputed moderation underdosing The question in the title: Why we hide unevidenced fraud accusations and log the hiding I will give what I have already checked below so nobody repeats it. Structured report rather than an opinion, following…	+12	16	17k	12mo
Why oral semaglutide needs an absorption enhancer at all — one year on Compounds › Oral incretins randomised trial SOUL trial oral semaglutide PIONEER programme Why oral semaglutide needs an absorption enhancer at all — one year on — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SCALE ( N Engl J Med , 2015) cited…	+11	15	17k	24d
Preprint servers and what screening they do — the long version Evidence › Preprints risk of bias effect size needs a source On the subject in the title: Preprint servers and what screening they do — the long version Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…	+7	11	26k	4mo
Patterns that reliably precede a problem, documented Sourcing › Red flags documentation quality disputed mislabelling underdosing Patterns that reliably precede a problem, documented — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than anywhere else I…	+3	7	31k	16mo
Pen wastage and its effect on real cost — the long version Access › Pricing formulary data table cost per milligram compounding Posting this under the heading it deserves: Pen wastage and its effect on real cost — the long version Everything below is what sits behind that. Documenting an access outcome, dated, because everything in…		2	34k	13mo
Priming a pen and whether the primed volume is wasted Devices › Pens & autoinjectors storage missed dose dead volume Solved Wiki Priming a pen and whether the primed volume is wasted Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+19	23	1.3k	2d
Sleep quality changes during weight loss Wellbeing › Sleep heart rate obstructive sleep apnoea fatigue On the subject in the title: Sleep quality changes during weight loss Working notes rather than a conclusion. Asking about a population rather than about a person. The published trials in this class mostly…	+27	31	555	5h
Gradient steepness and apparent purity: a worked comparison — the long version Analytics › HPLC & UHPLC HPLC system suitability gradient method Gradient steepness and apparent purity: a worked comparison — the long version — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I…		2	32k	1d