Ranked by engagement

Top topics — all time page 36

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 36 of 40

Topic	Participants	Replies	Views	Activity
Airline travel with a temperature-sensitive injectable Devices › Cold chain freeze-thaw cold chain temperature excursion storage Posting this under the heading it deserves: Airline travel with a temperature-sensitive injectable Everything below is what sits behind that. A question about technique rather than about dose. I have been…	+19	23	4.9k	7mo
Coming back to: Half-life, steady state, and accumulation worked through Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example semaglutide On the subject in the title: Half-life, steady state, and accumulation worked through Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. semaglutide…	+14	18	15k	3mo
What to bring: records that a clinician can actually use Clinical › Prescriber conversations beginner friendly type 2 diabetes prior authorisation Solved Asking directly, because I could not find a straight answer: What to bring: records that a clinician can actually use Asking about a population rather than about a person. The published trials in this class…	+15	19	6.4k	1d
Follow-up: Open-label extensions: what survives and what does not Evidence › Trials open label intention to treat surrogate endpoints estimand Solved Open-label extensions: what survives and what does not — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with SURMOUNT-1 ( N Engl J Med , 2022) and…	+22	26	397	16mo
What would change my mind about repair peptides: a specific answer Compounds › Repair & healing peptides TB-500 needs a source preprint Under review What would change my mind about repair peptides: a specific answer — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4 ( JAMA , 2024). Please…	+26	30	1.1k	23h
Joined after a search result and stayed Lounge › Introductions beginner friendly onboarding Posting this under the heading it deserves: Joined after a search result and stayed Everything below is what sits behind that. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim.…	+5	9	26k	7h
Reconciling a supplier certificate with an independent result Sourcing › Vendor reports third-party testing Janoshik Analytical certificate of analysis Reconciling a supplier certificate with an independent result — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the…	+18	24	347	9mo
Preservatives: function, testing, and limits Pharmacology › Formulation chemistry counter-ion content storage bacteriostatic water sterile water Preservatives: function, testing, and limits — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked. tirzepatide has a…	+23	27	3.7k	16mo
The 2.5 mg starting dose is not a therapeutic dose — why that matters — a second dataset Compounds › Tirzepatide SURMOUNT programme tirzepatide randomised trial Posting this under the heading it deserves: The 2.5 mg starting dose is not a therapeutic dose — why that matters — a second dataset Everything below is what sits behind that. Session topic: STEP 8 ( JAMA ,…	+12	16	11k	7mo
Documenting a payment dispute without naming and shaming — the long version Sourcing › Payments documentation quality payments research use only Posting this under the heading it deserves: Documenting a payment dispute without naming and shaming — the long version Everything below is what sits behind that. I would like to talk about documentation…		2	32k	1mo
[2026 update] Correlation in a self-tracked dataset: what it can support Research Methods › Statistics number needed to treat effect size worked example heterogeneity Posting this under the heading it deserves: Correlation in a self-tracked dataset: what it can support Everything below is what sits behind that. I have seen SURMOUNT-4 ( JAMA , 2024) cited in support of a…		2	31k	6h
Storing a pen in use versus a pen unopened Devices › Pens & autoinjectors storage missed dose dead volume Storing a pen in use versus a pen unopened Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how quickly these go…	+14	18	13k	14mo
A request that was declined, and the reasoning Documentation › Wiki requests promoted to docs maintainership review date On the subject in the title: A request that was declined, and the reasoning Working notes rather than a conclusion. Process question about how this site works. I have read the guidelines and the trust-level…		2	33k	17mo
Secretagogues and glucose tolerance: the mechanistic concern — what changed since Compounds › Secretagogues & GH axis GHRP class ipamorelin CJC-1295 observational data Wiki Closed Secretagogues and glucose tolerance: the mechanistic concern — what changed since Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021)…	+2	6	31k	2mo
Purity assay versus content assay: two different numbers Analytics › COA interpretation documentation quality batch & lot numbers reference standards certificate of analysis On the subject in the title: Purity assay versus content assay: two different numbers Working notes rather than a conclusion. I would like to understand what this number means before I repeat it anywhere. A…	+6	10	24k	25d
How to ask for a dose change without antagonising anyone Clinical › Prescriber conversations telehealth beginner friendly type 2 diabetes Solved The question in the title: How to ask for a dose change without antagonising anyone I will give what I have already checked below so nobody repeats it. Asking about a population rather than about a person.…	+19	23	2.9k	23mo
Second pass at: Why chargeback is not the safety net people assume Sourcing › Payments documentation quality research use only payments Solved Second pass at: Why chargeback is not the safety net people assume Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually…		2	25k	3mo
Validating a method you did not develop Analytics › Method validation precision & repeatability recovery linearity stability-indicating method On the subject in the title: Validating a method you did not develop Working notes rather than a conclusion. I would like to understand what this number means before I repeat it anywhere. A VendorInvestigate…	+10	14	15k	3mo
Tesamorelin has an approved indication — what that changes about the evidence Compounds › Secretagogues & GH axis observational data tesamorelin GHRP class CJC-1295 Tesamorelin has an approved indication — what that changes about the evidence — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURMOUNT-1 ( N Engl J…	+23	27	3.4k	1d
Escalating every six weeks instead of four: what I observed over eight months Practice › Dosing & titration titration worked example dose reduction Escalating every six weeks instead of four: what I observed over eight months Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+27	31	432	18mo
An appeal that succeeded, with the letter structure Access › Insurance & coverage appeals formulary prior authorisation insurance On the subject in the title: An appeal that succeeded, with the letter structure Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As…	+12	16	15k	1d
Requesting a translation of an existing page Documentation › Wiki requests wiki post maintainership review date Requesting a translation of an existing page — setting out what I have, and where I think it stops being reliable. Process question about how this site works. I have read the guidelines and the trust-level…	+16	20	7.1k	14mo
SNAC and the mechanism of oral peptide absorption Compounds › Oral incretins orforglipron randomised trial PIONEER programme oral semaglutide On the subject in the title: SNAC and the mechanism of oral peptide absorption Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with SURPASS-4 ( Lancet , 2021) and finding the…	+13	17	14k	17mo
[2026 update] Temperature indicator cards: worth asking for? Sourcing › Logistics shipping packaging customs temperature excursion Temperature indicator cards: worth asking for? I have a specific reason for asking rather than idle curiosity, and the context is below. A logistics question, since the answers here are usually better than…	+21	26	4.5k	1d
Mass error in ppm: the arithmetic and the caveat — a second dataset Analytics › Mass spectrometry counter-ion content mass error (ppm) charge states LC-MS Solved On the subject in the title: Mass error in ppm: the arithmetic and the caveat — a second dataset Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked.…	+20	24	1.7k	1d
Naming conventions for research peptides and the confusion they cause Compounds › Other compounds custom synthesis mislabelling research use only needs a source Posting this under the heading it deserves: Naming conventions for research peptides and the confusion they cause Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with STEP 1 ( N…	+21	25	4.9k	22d
Follow-up: Trifluoroacetate content and its consequences Analytics › Impurities & related substances counter-ion content endotoxin testing HPLC data table Solved Closed On the subject in the title: Trifluoroacetate content and its consequences Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will otherwise be.…	+12	16	5.7k	21mo
Absence of evidence and evidence of absence Research Methods › Statistics effect size worked example number needed to treat Absence of evidence and evidence of absence Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med , 2024). Please read it before…	+16	20	3.9k	5mo
Review: an evidence digest and the citation check that delayed it Documentation › Doc review citation check review date promoted to docs wiki post On the subject in the title: Review: an evidence digest and the citation check that delayed it Working notes rather than a conclusion. Nominating something for promotion into the documentation commons. The…	+13	17	15k	2d
Revisiting: Theoretical plates: useful number or ritual? Analytics › HPLC & UHPLC system suitability UV & DAD detection gradient method data table Solved Asking directly, because I could not find a straight answer: Revisiting: Theoretical plates: useful number or ritual? I would like to understand what this number means before I repeat it anywhere. A…	+16	21	1.2k	1d