Ranked by engagement

Top topics — this quarter page 14

Ranked by replies, likes and views over this quarter, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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515 topics · page 14 of 14

Topic	Participants	Replies	Views	Activity
Evidence quality in the secretagogue literature: an honest assessment Compounds › Secretagogues & GH axis ipamorelin observational data GHRP class tesamorelin Solved Evidence quality in the secretagogue literature: an honest assessment Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024) with STEP…		2	25k	9d
Reference intervals: how they are constructed and why one in twenty flags — does this still hold? Clinical › Bloodwork thyroid function liver enzymes lipid panel HbA1c Solved Asking directly, because I could not find a straight answer: Reference intervals: how they are constructed and why one in twenty flags — does this still hold? General question, not a request for advice about…	+18	22	281	2h
About the N-of-1 designs category Research Methods › N-of-1 designs worked example confounding effect size Pinned Wiki Designing a personal experiment that could actually change your mind, including washouts and blinding. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	22k	14h
What to include when your question involves a laboratory result Start Here › How to Ask beginner friendly site feedback guidelines Asking directly, because I could not find a straight answer: What to include when your question involves a laboratory result Question in the title. Context below, and I have tried to include the things people…	+8	12	14k	2d
Is "synergy" the right word for the combination data? Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide effect size Is "synergy" the right word for the combination data? — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SCALE ( N Engl J Med , 2015). Please read it…	+5	9	13k	25d
A comparison of home results against a laboratory result on the same vial — does this still hold? Analytics › Home & field testing ELISA third-party testing LOD & LOQ documentation quality Solved A comparison of home results against a laboratory result on the same vial — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Working through the…	+2	6	15k	11h
About the Reconstitution category Practice › Reconstitution reconstitution concentration maths syringe units Pinned Wiki Diluent choice, volumes, resulting concentrations, worked examples, and the errors we see most often. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+1	5	15k	16h
Follow-up: External review after an internal denial Access › Insurance & coverage prior authorisation formulary insurance Solved Posting this under the heading it deserves: External review after an internal denial Everything below is what sits behind that. A coverage question with the paperwork detail included, since that is what…	+6	10	12k	15h
When your prescriber and the evidence disagree Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes When your prescriber and the evidence disagree — that is the question, and I have not found it answered plainly anywhere I have looked. General question, not a request for advice about my own care — I know…	+14	18	273	2d
Why retatrutide discussion here is more cautious than elsewhere Compounds › Retatrutide randomised trial effect size retatrutide preprint Solved Why retatrutide discussion here is more cautious than elsewhere I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited…	+7	12	7.7k	2mo
Whether an aggregate is worth publishing at all: a disputed topic — does this still hold? Data & Tools › Datasets data table confounding observational data Solved Whether an aggregate is worth publishing at all: a disputed topic — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand…	+14	18	3.4k	2mo
Revisiting: Drawing from a pen cartridge with a syringe: how the risk profile changes Devices › Pens & autoinjectors dead volume missed dose storage subcutaneous injection Revisiting: Drawing from a pen cartridge with a syringe: how the risk profile changes Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this…		2	18k	6h
About the COA interpretation category Analytics › COA interpretation certificate of analysis documentation quality batch & lot numbers Pinned Wiki What a certificate of analysis commits its issuer to, which fields matter, and how to spot one that says almost nothing. This post is a community wiki: any member at trust level 3 or above can edit it, and…	+8	12	8.5k	2mo
Sleep apnoea improving and the equipment implications Wellbeing › Sleep obstructive sleep apnoea heart rate fatigue Sleep apnoea improving and the equipment implications Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+14	18	1.1k	17h
Distinguishing a red flag from an inconvenience — a second dataset Sourcing › Red flags moderation documentation quality disputed On the subject in the title: Distinguishing a red flag from an inconvenience — a second dataset Working notes rather than a conclusion. A logistics question, since the answers here are usually better than…	+8	12	9.6k	1d
Repeatability versus intermediate precision — what changed since Analytics › Method validation recovery precision & repeatability linearity system suitability Posting this under the heading it deserves: Repeatability versus intermediate precision — what changed since Everything below is what sits behind that. Working through the identity arithmetic and I would like…		4	21k	5h
Delayed gastric emptying and oral medication absorption: which drugs matter — one year on Practice › Interactions needs a source delayed gastric emptying hypoglycaemia insulin Solved Closed On the subject in the title: Delayed gastric emptying and oral medication absorption: which drugs matter — one year on Working notes rather than a conclusion. I have read the maintained page on this and I…		3	16k	2mo
Why side effects reset at each escalation and that is not a failure Practice › Side effects constipation nausea fatigue delayed gastric emptying Solved Why side effects reset at each escalation and that is not a failure — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still…	+3	7	11k	14h
Restarting after a long gap: what the labelling implies — the long version Practice › Dosing & titration tirzepatide worked example dose reduction semaglutide Restarting after a long gap: what the labelling implies — the long version Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+12	17	2.4k	2mo
Coming back to: Light exposure: how much protection is proportionate? Practice › Storage & stability temperature excursion cold chain freeze-thaw cloudy or discoloured solution Asking directly, because I could not find a straight answer: Light exposure: how much protection is proportionate? Practical question with the units stated, because I have seen how quickly these go wrong…	+5	10	13k	2d
Fatigue in the first month: how much is the drug and how much is intake Practice › Side effects vomiting fatigue constipation Solved On the subject in the title: Fatigue in the first month: how much is the drug and how much is intake Working notes rather than a conclusion. A question about technique rather than about dose. I have been…		4	17k	3mo
[2026 update] Journal club: FLOW and the renal composite, component by component Evidence › Journal club journal club randomised trial estimand Journal club: FLOW and the renal composite, component by component Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in…		2	21k	9d
Follow-up: An emergency department visit, described afterwards Safety › Adverse events gallbladder delayed gastric emptying vomiting On the subject in the title: An emergency department visit, described afterwards Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference…		4	18k	1mo
A 40-week log with the measurement method stated — what changed since Outcomes › Progress reports effect size data table DXA long read Solved A 40-week log with the measurement method stated — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Longitudinal report with the method stated, because a…	+9	13	2.1k	9h
External review after an internal denial Access › Insurance & coverage appeals prior authorisation insurance formulary Solved External review after an internal denial Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that is what…		2	18k	1mo
About the Preprints category Evidence › Preprints preprint risk of bias needs a source Pinned Wiki Unrefereed work, clearly labelled as such, with the usual caveats stated once and taken seriously. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…	+3	7	14k	3mo
A 40-week log with the measurement method stated — does this still hold? Outcomes › Progress reports effect size DXA data table Solved A 40-week log with the measurement method stated — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Longitudinal report with the method stated,…	+1	5	14k	2mo
A structured critique template this community uses Evidence › Study critique observational data effect size risk of bias A structured critique template this community uses — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with SURPASS-4 ( Lancet , 2021) and finding the…		2	18k	1d
Impurity thresholds: where the common numbers come from Analytics › Impurities & related substances water content data table forced degradation counter-ion content Impurity thresholds: where the common numbers come from — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in…	+11	15	825	2d
About the Adverse events category Safety › Adverse events pancreatitis vomiting gallbladder Pinned Wiki Serious and unexpected events, how to document them, and where to report them officially. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+2	6	8.7k	2d