a.finnegan_rd

TL2 Dietitian · Galway, IE

Dietitian. Electrolytes, hydration and the very ordinary reasons people feel awful in week two.

Joined 2 December 2024 · last posted 1d · groups: clinicians

94 posts, newest first. Showing up to 150.

Coming back to: Telehealth prescribing models in the US Replied, post #30 · Regional › North America · 26 Jul 2026 · 9 likes Coming back to post #28, because the follow-up matters more than the original answer. Compounding pharmacies: pharmaceutical compounding of a drug not on the FDA…
What I would want from a home test that does not exist yet — what changed since Replied, post #111 · Analytics › Home & field testing · 26 Jul 2026 · 31 likes What physical quantity does the device measure? A colorimetric or lateral-flow method typically responds to a class of chemistry rather than to a specific molecule. It…
Follow-up: How compounding permissions changed when supply normalised Replied, post #70 · Sourcing › Regulatory · 25 Jul 2026 · 5 likes post #69 answers the question as asked. The question underneath it is different. Why this category is maintained as documentation, not as recommendations: the goal is…
Pooling trials with different estimands Replied, post #124 · Evidence › Meta-analyses · 24 Jul 2026 · 3 likes This follows post #121 rather than contradicting it. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still…
Revisiting: Taste changes and food aversion, reported and discussed Replied, post #24 · Practice › Side effects · 23 Jul 2026 · 0 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Programming during a large energy deficit Replied, post #45 · Nutrition & Training › Resistance training · 20 Jul 2026 · 0 likes Adaptation and plateau: if strength does not change for weeks, that is stability, not backsliding. Expecting continuous progress during weight loss is unrealistic.
Why the timeline is on the right and not the left — what changed since Replied, post #78 · Meta › Site feedback · 20 Jul 2026 · 8 likes Accessibility: screen readers, keyboard navigation, contrast, font size — if something is not accessible to you, report it. Accessibility matters.
A site rotation scheme that is easy enough to actually follow Replied, post #115 · Practice › Administration · 15 Jul 2026 · 0 likes Leak-back after withdrawal: a small amount of liquid on the skin after withdrawal is ordinary. Whether you lost a "meaningful" dose depends on concentration and your…
eGFR fluctuation and the creatinine denominator problem Started this topic · Clinical › Bloodwork · 6 Jul 2026 · 46 likes On the subject in the title: eGFR fluctuation and the creatinine denominator problem Working notes rather than a conclusion. General question, not a request for advice…
Does a peptide degrade silently, with no visual change? Replied, post #61 · Practice › Storage & stability · 2 Jul 2026 · 2 likes Container choice matters: the material of the vial, the rubber closure, the fill volume all affect how quickly the contents degrade. Smaller fill volumes lose less to…
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #34 · Analytics › Home & field testing · 28 Jun 2026 · 0 likes Molecular tests: DNA or RNA tests are not applicable to peptides, which do not contain nucleic acids. Peptide-specific tests rely on protein recognition, not…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #24 · Analytics › Impurities & related substances · 25 Jun 2026 · 6 likes Dimer and higher-order multimers: two or more peptide molecules bonded together. They appear at double the mass and higher. They may or may not separate from the…
Sleep quality changes during weight loss Replied, post #2 · Wellbeing › Sleep · 24 Jun 2026 · 2 likes Sleep quality versus quantity: some people report changes to sleep duration; others report changes to sleep quality without duration change. Both can matter for…
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #14 · Practice › Dosing & titration · 24 Jun 2026 · 4 likes post #13 is right about the mechanism and I think understates the practical bit. I disagree with the reply above, and I think the disagreement is substantive rather…
Follow-up: The most useful thing you learned here that was not the answer you came for Replied, post #9 · Lounge › Off topic · 18 Jun 2026 · 15 likes This follows post #6 rather than contradicting it. Industry and supply chain: post about manufacturing, pharmaceutical economics, or market dynamics if you have…
Constipation management, with a dietitian's contribution Replied, post #75 · Practice › Side effects · 6 Jun 2026 · 21 likes Worth separating two things that post #71 runs together. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did…
Cold solution and stinging: the simplest fix Replied, post #32 · Practice › Administration · 5 Jun 2026 · 0 likes Drawing up with one needle and injecting with another: a reasonable practice if you have extra needles. Fresh needle for injection reduces tissue drag and can decrease…
What to include when your question involves a chromatogram — one year on Replied, post #26 · Start Here › How to Ask · 5 Jun 2026 · 20 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Alcohol: what is documented and what is folklore Replied, post #40 · Practice › Interactions · 3 Jun 2026 · 14 likes Metformin: commonly co-administered and relevant to gastrointestinal tolerability. Gastrointestinal side effects can overlap and additive. Taking them separately or…
Preservatives: function, testing, and limits — one year on Replied, post #16 · Pharmacology › Formulation chemistry · 12 May 2026 · 32 likes post #15 is right about the mechanism and I think understates the practical bit. Emulsification and suspensions: some formulations are emulsions or suspensions rather…
[2026 update] What a purity-only report leaves out Replied, post #90 · Sourcing › Independent verification · 14 Apr 2026 · 2 likes Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest ways for a result to be shaped: selective submission and…
Rotating between abdomen, thigh and upper arm: absorption differences — one year on Replied, post #43 · Practice › Administration · 6 Apr 2026 · 11 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Search filters: what is missing Replied, post #43 · Meta › Site feedback · 4 Apr 2026 · 26 likes Guideline clarity: if the guidelines are unclear or seem to be applied inconsistently, post the specific situation so staff can clarify or reconsider.
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #52 · Outcomes › Body composition · 3 Apr 2026 · 1 like Visceral fat: DXA does not distinguish visceral (organ-associated) fat from subcutaneous fat. That distinction might matter but requires different imaging to measure.
Foaming during reconstitution and whether it matters — the long version Replied, post #84 · Practice › Reconstitution · 2 Apr 2026 · 0 likes Picking up post #81: that is the part I would want checked first. Choosing a concentration on purpose rather than by accident: starting with "I want to draw 0.5 mL per…
The most useful thing you learned here that was not the answer you came for Replied, post #31 · Lounge › Off topic · 31 Mar 2026 · 1 like Picking up post #28: that is the part I would want checked first. Adjacent and interesting: you might post something about nutrition, bioavailability from a food…
Measurement error in home scales, with a worked standard deviation — the long version Replied, post #59 · Research Methods › Statistics · 22 Mar 2026 · 4 likes Worth separating two things that post #55 runs together. Confidence intervals: rather than a single point estimate, a range of plausible values. A narrow interval means…
Washout with a one-week half-life: the arithmetic — does this still hold? Started this topic · Research Methods › N-of-1 designs · 20 Mar 2026 · 17 likes Washout with a one-week half-life: the arithmetic — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked.…
Coming back to: Washout: how long is long enough, and for what purpose Replied, post #74 · Pharmacology › Pharmacokinetics · 17 Mar 2026 · 25 likes Picking up post #71: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
The "under review" status pill and when a moderator applies it Replied, post #23 · Evidence › Preprints · 16 Mar 2026 · 9 likes post #22 answers the question as asked. The question underneath it is different. Discussing preprints in this community: bring them in for early discussion, label them…
An ABAB design with a data table and honest limitations — a second dataset Replied, post #66 · Research Methods › N-of-1 designs · 15 Mar 2026 · 16 likes Blinding: blinding yourself (not knowing which condition you are in) removes expectation bias. This is hard to do with these compounds (the appetite suppression is hard…
Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Replied, post #2 · Compounds › Oral incretins · 12 Mar 2026 · 10 likes Fasting instructions are not optional advice. Taking the tablet with food or with more than a sip of water measurably reduces absorption. This is the one compound in…
Nausea profile of amylin analogues compared with GLP-1 agonists Replied, post #50 · Compounds › Cagrilintide & amylin analogues · 8 Mar 2026 · 12 likes What is genuinely unknown about long-term amylin agonism: real-world response rates, whether effect is durable with continued use, whether satiety adaptation occurs…
Injection discomfort: needle gauge, volume, temperature, technique Replied, post #35 · Practice › Administration · 8 Mar 2026 · 31 likes post #34 is right about the mechanism and I think understates the practical bit. Cold solution and stinging: warming the vial in your hands for a minute before…
Splitting a weekly dose in two: the pharmacokinetic argument against Replied, post #7 · Practice › Dosing & titration · 4 Mar 2026 · 11 likes Worth separating two things that post #3 runs together. Holding a dose indefinitely: the trials did not study indefinite holding at a non-maximum dose. The trials…
Anaesthesia and elective surgery: the aspiration question Replied, post #29 · Practice › Interactions · 22 Feb 2026 · 30 likes Picking up post #26: that is the part I would want checked first. Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K) might be…
Research-use-only status: what it means legally and practically Replied, post #5 · Compounds › Other compounds · 16 Feb 2026 · 0 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #12 · Practice › Dosing & titration · 15 Feb 2026 · 0 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Personal import allowances, compared — a second dataset Replied, post #66 · Access › International · 9 Feb 2026 · 0 likes Language barriers: if you need to communicate with a supplier, clinician, or regulator in a language not your first language, misunderstanding is possible. Clarify when…
Trifluoroacetate content and its consequences Replied, post #117 · Analytics › Impurities & related substances · 9 Feb 2026 · 1 like Off-target structures: if the sequence synthesis goes wrong, a completely different amino acid can be incorporated. The resulting off-target peptide is a structural…
Trifluoroacetate content and its consequences Replied, post #50 · Analytics › Impurities & related substances · 30 Jan 2026 · 16 likes post #49 is right about the mechanism and I think understates the practical bit. Thank you for the correction. I have edited my earlier post with a note rather than…
Request: export my own posts Replied, post #2 · Meta › Feature requests · 18 Jan 2026 · 14 likes Deprecation requests: if you think a feature should be removed or changed, that is also a request. Explain why you think it would improve the site.
"Greater than or equal to 99%" as a specification rather than a result Replied, post #108 · Analytics › COA interpretation · 11 Jan 2026 · 2 likes A certificate of analysis is a statement by its issuer that a defined test was performed on a defined lot and produced a defined result. That is all it is, and it is…
Revisiting: A page that has drifted out of date and needs a maintainer Replied, post #27 · Documentation › Wiki requests · 7 Jan 2026 · 15 likes I read post #25 twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write…
Storing lyophilised material long term: what governs the shelf life Replied, post #7 · Practice › Storage & stability · 27 Dec 2025 · 27 likes post #6 is right about the mechanism and I think understates the practical bit. Temperature excursions: if a vial sat at room temperature for a time, the question is…
Vomiting: when it is expected and when it is a reason to stop Replied, post #19 · Practice › Side effects · 26 Dec 2025 · 7 likes Lean mass loss: the rate of lean tissue loss depends on protein intake, resistance training volume, and total energy deficit. Adequate protein and maintaining training…
Vomiting: when it is expected and when it is a reason to stop Replied, post #10 · Practice › Side effects · 26 Dec 2025 · 26 likes Injection site reaction: local erythema, nodules, or induration at injection sites is reported by some people. Site rotation, avoiding reinjection into the same area…
Reading SURMOUNT-1 without the press release — one year on Replied, post #32 · Compounds › Tirzepatide · 23 Dec 2025 · 3 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Pre-registering a personal experiment, seriously — a second dataset Replied, post #3 · Research Methods › N-of-1 designs · 14 Nov 2025 · 0 likes Washout periods: after stopping a medication, how long does it take for the effect to wash out? For compounds with a week-long half-life, roughly a month is needed to…
Titles that describe the question, not the situation Replied, post #149 · Start Here › How to Ask · 14 Nov 2025 · 0 likes The specific question in the title is more useful than you might think. A title like "a question I have" forces the person answering to guess what you want to know. A…
Batch date after test date, and other internal inconsistencies Replied, post #12 · Analytics › COA interpretation · 28 Oct 2025 · 0 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Can a home kit substitute for a laboratory report? A careful no Replied, post #36 · Analytics › Home & field testing · 22 Oct 2025 · 21 likes Picking up post #33: that is the part I would want checked first. Immunoassay limitations: tests that use antibodies have cross-reactivity limitations. An antibody…
Reading SURMOUNT-1 without the press release Replied, post #28 · Compounds › Tirzepatide · 8 Oct 2025 · 0 likes Worth separating two things that post #24 runs together. SURMOUNT-4 used a randomised withdrawal design: everyone titrated, then those on maintenance were randomised to…
Follow-up: Why the titration planner refuses to produce a schedule below a floor Replied, post #136 · Data & Tools › Calculators · 1 Oct 2025 · 9 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Revisiting: German, French and Dutch differences, compared Replied, post #79 · Regional › European Union · 28 Sep 2025 · 19 likes Germany: BfArM implements EU framework. Statutory insurance (the majority) excludes "lifestyle medicines" including weight management. Private prescription is common.…
What a purity-only report leaves out Replied, post #14 · Sourcing › Independent verification · 14 Sep 2025 · 12 likes post #13 answers the question as asked. The question underneath it is different. Blind sampling: submitting without the laboratory or seller knowing the source removes…
Journal club: STEP 3 and the intensive behavioural therapy floor — does this still hold? Replied, post #2 · marked as the solution · Evidence › Journal club · 26 Aug 2025 · 11 likes Session format: read the paper before posting. The discussion is much better when everyone has. Start with the estimand and population, then methods, then results, then…
What this community means by "a source", in practical terms Replied, post #86 · Start Here › Welcome · 26 Aug 2025 · 1 like Marked solutions are the site's way of saying that someone asked a good question and someone else gave an answer that actually worked. It is not a competition and it…
Follow-up: Why the titration planner refuses to produce a schedule below a floor Replied, post #77 · Data & Tools › Calculators · 9 Aug 2025 · 0 likes Storage lookup: which conditions (temperature, time) are you considering storing in, and how much stability loss is expected? The calculator gives a rough estimate…
Sodium, potassium and magnesium when intake drops Replied, post #56 · Nutrition & Training › Hydration & electrolytes · 13 Jul 2025 · 0 likes post #55 answers the question as asked. The question underneath it is different. Exercise and electrolyte losses: sweating during exercise increases sodium and…
Why the timeline is on the right and not the left Replied, post #37 · Meta › Site feedback · 5 Jul 2025 · 0 likes Accessibility: screen readers, keyboard navigation, contrast, font size — if something is not accessible to you, report it. Accessibility matters.
Coming back to: An 18-month record including the parts that went badly Replied, post #69 · Outcomes › Progress reports · 21 Jun 2025 · 13 likes Rate of change: reporting progress as "lost 5 kg in 12 weeks" is more useful than "currently at 82 kg" because the rate tells you whether the change is steady,…
Coming back to: Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #35 · Compounds › Semaglutide · 20 Jun 2025 · 0 likes Picking up post #32: that is the part I would want checked first. The SELECT trial changed the positioning because it was the first cardiovascular outcome trial in…
EU-wide position versus national implementation Replied, post #8 · marked as the solution · Regional › European Union · 1 Jun 2025 · 7 likes France: ANSM implements EU framework. Reimbursement has been narrower for weight management. Prescribing restrictions were applied during shortages, directing available…
Counter-ion content and its effect on measured mass Replied, post #52 · Analytics › Mass spectrometry · 31 May 2025 · 0 likes Mass accuracy is expressed in parts per million. It is the difference between observed and theoretical mass divided by theoretical mass, multiplied by a million. A…
[2026 update] Building a sensible monitoring schedule with your prescriber Replied, post #26 · Clinical › Bloodwork · 28 May 2025 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Regression to the mean in progress reports Replied, post #11 · Research Methods › Statistics · 19 May 2025 · 9 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Relative retention time as a better inter-laboratory comparator Replied, post #7 · Analytics › Method validation · 6 May 2025 · 0 likes post #6 answers the question as asked. The question underneath it is different. For anyone arriving from a search: the marked solution above is the direct answer, and…
Metformin co-administration and additive GI effects Replied, post #2 · Practice › Interactions · 17 Apr 2025 · 0 likes the opening post answers the question as asked. The question underneath it is different. Thank you for the correction. I have edited my earlier post with a note rather…
Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Replied, post #14 · Evidence › Journal club · 10 Apr 2025 · 0 likes SURPASS-2 (N Engl J Med 2021): Direct comparison of tirzepatide with semaglutide 1.0 mg. The 1.0 mg dose is not the highest available, which is the central and…
One lot is one lot: when a report becomes a pattern — the long version Replied, post #111 · Sourcing › Vendor reports · 18 Mar 2025 · 0 likes Worth separating two things that post #107 runs together. Blind submission is worth the effort: have someone else relabel the sample so neither you nor the laboratory…
Scheduled maintenance and what will be unavailable Replied, post #62 · Meta › Announcements · 4 Mar 2025 · 16 likes Implementation timeline: announcements include when a change takes effect. Marking the date helps you know whether the change is already in effect.
Consistent declarations and why they matter more than clever ones Replied, post #67 · Sourcing › Logistics · 22 Feb 2025 · 0 likes Reshipment after seizure: if a parcel is seized, some suppliers will reship; others will not. That is a supplier choice and should be understood before ordering in a…
Reconstituting a multi-strength kit without mixing yourself up Replied, post #26 · Practice › Reconstitution · 28 Jan 2025 · 0 likes Foaming during reconstitution: bubbles in the solution are usually just air incorporated during mixing. They usually resolve with gentle warming and time. Persistent…
Follow-up: Individual participant data versus aggregate data Replied, post #58 · Evidence › Meta-analyses · 10 Jan 2025 · 3 likes Study quality and weighting: some meta-analyses weight all studies equally; others weight by study size or study quality. The choice affects the result and should be…
Oral semaglutide bioavailability and its variability between people — a second dataset Replied, post #152 · Compounds › Oral incretins · 29 Dec 2024 · 4 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Coming back to: When to suspect the method rather than the sample Replied, post #110 · Analytics › Method validation · 21 Dec 2024 · 5 likes Worth separating two things that post #106 runs together. Precision and repeatability: within-run and between-run variability of the method. Acceptance criterion is…
Body image changing more slowly than the body Replied, post #87 · Wellbeing › Mental health · 21 Dec 2024 · 15 likes Coming back to post #85, because the follow-up matters more than the original answer. When to involve a professional: if mood changes are persistent, deepen over weeks,…
Body image changing more slowly than the body Replied, post #64 · Wellbeing › Mental health · 18 Dec 2024 · 2 likes post #63 answers the question as asked. The question underneath it is different. Body image and weight loss: large weight loss changes a person's relationship with…
Fibre intake when total intake falls, and the constipation link Replied, post #5 · Nutrition & Training › Protein & intake · 7 Dec 2024 · 29 likes Coming back to post #3, because the follow-up matters more than the original answer. Micronutrition alongside protein: eating protein foods that are also good sources…
[2026 update] New subcategory: rationale and scope Replied, post #42 · Meta › Announcements · 4 Dec 2024 · 9 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
What changed in 2026, by region Started this topic · Access › International · 26 Nov 2024 · 52 likes What changed in 2026, by region — that is the question, and I have not found it answered plainly anywhere I have looked. Documenting an access outcome, dated, because…
EMA product information as a primary source — does this still hold? Replied, post #115 · Regional › European Union · 18 Nov 2024 · 2 likes On post #111 — agreed on the reasoning, with one qualification. EMA is the regulator with national implementation. Licensed incretin analogues are prescription-only…
EMA product information as a primary source — does this still hold? Replied, post #87 · Regional › European Union · 17 Nov 2024 · 27 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
EMA product information as a primary source — does this still hold? Replied, post #64 · Regional › European Union · 16 Nov 2024 · 24 likes post #63 answers the question as asked. The question underneath it is different. Spain: AEMPS is the regulator. Public reimbursement for weight management has been…
When to suspect the method rather than the sample Replied, post #35 · Analytics › Method validation · 11 Nov 2024 · 0 likes Worth separating two things that post #31 runs together. Forced degradation studies: deliberately stress the material with acid, base, oxidant, heat, light to generate…
[2026 update] Step therapy requirements and how to satisfy them Replied, post #21 · Access › Insurance & coverage · 10 Nov 2024 · 1 like Worth separating two things that post #17 runs together. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather…
Why "any advice?" is the least effective ending for a post Replied, post #15 · Start Here › How to Ask · 7 Nov 2024 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Follow-up: Tirzepatide's shorter half-life and its one practical consequence Replied, post #14 · Compounds › Tirzepatide · 29 Oct 2024 · 4 likes I read post #12 twice before replying, because I had assumed the opposite. Dual agonism versus dose: how much of tirzepatide's effect is the GIP component and how much…
Oxidation and deamidation mass shifts, tabulated Started this topic · Analytics › Mass spectrometry · 26 Oct 2024 · 8 likes Posting this under the heading it deserves: Oxidation and deamidation mass shifts, tabulated Everything below is what sits behind that. Working through the identity…
Tracking a preprint to publication: a worked example — the long version Replied, post #45 · Evidence › Preprints · 4 Oct 2024 · 31 likes post #44 is right about the mechanism and I think understates the practical bit. How to cite a preprint: author last name, first initial, et al. Title. Server name…
Splitting a vial for two laboratories: how to do it without ruining both — what changed… Replied, post #46 · Sourcing › Independent verification · 9 Sep 2024 · 0 likes Service differences on vendor pages: Janoshik and Medutest results are measurements on vials. PeptideMeter verification records are assessments maintained over time.…
Circumference measurements as a poor man's composition estimate Replied, post #10 · Outcomes › Body composition · 20 Jul 2024 · 3 likes Ultrasound: thickness of subcutaneous fat at specific sites. Less standardised than DXA and operator-dependent. Useful as a supplementary measure but not as a primary…
Where the four-week escalation interval comes from, and what it is not Replied, post #33 · Practice › Dosing & titration · 28 Jun 2024 · 2 likes Holding a dose indefinitely: the trials did not study indefinite holding at a non-maximum dose. The trials escalated to a target and then held that. What happens if you…