Latest topics page 37

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 37 of 52

Topic	Participants	Replies	Views	Activity
A request that was declined, and the reasoning — a second dataset Documentation › Wiki requests maintainership promoted to docs wiki post Closed A request that was declined, and the reasoning — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Process question about how this site works. I have read the…	+89	98	31k	11mo
Second pass at: What a reversed-phase purity number actually is Analytics › HPLC & UHPLC peak integration UV & DAD detection system suitability On the subject in the title: Second pass at: What a reversed-phase purity number actually is Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…		2	7.4k	11mo
Coming back to: Semaglutide half-life: where the 165 to 184 hour figure comes from Compounds › Semaglutide SELECT trial type 2 diabetes semaglutide Semaglutide half-life: where the 165 to 184 hour figure comes from Writing it up because I had to work it out twice and would rather nobody else did. Putting the numbers in the first post, because a question…	+112	119	3.3k	11mo
[2026 update] Heterogeneity as information rather than as a nuisance Evidence › Meta-analyses publication bias heterogeneity meta-analysis Heterogeneity as information rather than as a nuisance Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I…		4	32k	11mo
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly Compounds › Tirzepatide tirzepatide SURPASS programme randomised trial effect size Solved Closed Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin tirzepatide in type 2…	+150	163	22k	11mo
Coming back to: When "no data" is the complete and final answer Compounds › Other compounds research use only needs a source custom synthesis When "no data" is the complete and final answer I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about the compound itself rather than about a trial of it. I…	+77	82	12k	11mo
The storage lookup and where its data comes from Data & Tools › Calculators worked example site feedback syringe units concentration maths Solved Closed The storage lookup and where its data comes from — setting out what I have, and where I think it stops being reliable. Working notes on storage lookup rather than a conclusion. I would rather post the…	+4	8	4.1k	11mo
Revisiting: List price versus negotiated price versus what you pay Access › Pricing cost per milligram compounding data table formulary Revisiting: List price versus negotiated price versus what you pay — setting out what I have, and where I think it stops being reliable. Working notes on List price versus negotiated price rather than a…	+24	28	50k	12mo
Revisiting: Completing a dose with a second syringe, and the dead-volume arithmetic Practice › Administration subcutaneous injection aseptic technique needle gauge & length injection site reaction Closed Revisiting: Completing a dose with a second syringe, and the dead-volume arithmetic Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this…	+16	20	56k	12mo
Reading a denial letter as a specification for your appeal Access › Insurance & coverage appeals prior authorisation insurance Closed Reading a denial letter as a specification for your appeal Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here about reading a…		3	30k	12mo
IGF-1 as a surrogate endpoint and its limitations — the long version Compounds › Secretagogues & GH axis CJC-1295 observational data ipamorelin needs a source Solved Closed On the subject in the title: IGF-1 as a surrogate endpoint and its limitations — the long version Working notes rather than a conclusion. A narrow question about IGF-1, deliberately narrow, because the broad…	+14	18	53k	12mo
Travel coolers and how long they really hold Devices › Cold chain temperature excursion storage freeze-thaw On the subject in the title: Travel coolers and how long they really hold Working notes rather than a conclusion. A narrow question about travel coolers, deliberately narrow, because the broad version has…	+78	84	14k	12mo
A ten-fold dose error caught before injection — one year on Devices › Syringes & needles dead volume needle gauge & length subcutaneous injection syringe units On the subject in the title: A ten-fold dose error caught before injection — one year on Working notes rather than a conclusion. Two things I would like separated before anyone answers on ten-fold dose error…	+151	157	9.4k	12mo
How to research a compound with no human data without deceiving yourself Compounds › Other compounds needs a source mislabelling custom synthesis research use only Solved Asking directly, because I could not find a straight answer: How to research a compound with no human data without deceiving yourself Question about what the published evidence for this compound actually…	+107	119	11k	12mo
Sequence verification for an obscure compound: how it is done Compounds › Other compounds needs a source custom synthesis research use only mislabelling Sequence verification for an obscure compound: how it is done Writing it up because I had to work it out twice and would rather nobody else did. Asking about sequence verification directly, because I have…	+104	114	10k	12mo
Coming back to: An 18-month record including the parts that went badly Outcomes › Progress reports DXA effect size long read Solved Posting this under the heading it deserves: An 18-month record including the parts that went badly Everything below is what sits behind that. Asking about 18-month record on behalf of the question I keep…	+83	89	52k	12mo
Antibiotics and a course of something with delayed emptying Practice › Interactions insulin hypoglycaemia needs a source metformin Antibiotics and a course of something with delayed emptying — setting out what I have, and where I think it stops being reliable. Something about antibiotics does not reconcile and I would like a second pair…	+99	108	1.4k	12mo
[2026 update] Reverting an edit that had no revision note Meta › Wiki maintenance wiki post citation check maintainership Reverting an edit that had no revision note — setting out what I have, and where I think it stops being reliable. Collecting what is known about Reverting an edit in one place, because it is currently spread…	+8	12	54k	12mo
Subcutaneous absorption kinetics and site differences Pharmacology › Pharmacokinetics missed dose worked example semaglutide Wiki Posting this under the heading it deserves: Subcutaneous absorption kinetics and site differences Everything below is what sits behind that. Asking about subcutaneous absorption kinetics and site directly,…	+15	19	3.9k	12mo
Domestic fridge temperature mapping: a cheap experiment — what changed since Devices › Cold chain cold chain storage freeze-thaw temperature excursion Domestic fridge temperature mapping: a cheap experiment — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Domestic fridge…	+145	155	46k	12mo
An appeal that failed, and what I would do differently Access › Insurance & coverage insurance appeals prior authorisation An appeal that failed, and what I would do differently Writing it up because I had to work it out twice and would rather nobody else did. Asking about appeal directly, because I have read four threads on it…	+4	8	125	12mo
Holding a dose indefinitely: is there a documented downside? Practice › Dosing & titration dose reduction missed dose semaglutide Holding a dose indefinitely: is there a documented downside? — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still have a…	+28	32	57k	12mo
Follow-up: Why we hide unevidenced fraud accusations and log the hiding Sourcing › Red flags mislabelling disputed moderation underdosing The question in the title: Why we hide unevidenced fraud accusations and log the hiding I will give what I have already checked below so nobody repeats it. Filing a documentation observation rather than a…	+12	16	17k	12mo
The C-cell question: rodent findings and their human context Compounds › Semaglutide STEP programme type 2 diabetes effect size Closed Posting this under the heading it deserves: The C-cell question: rodent findings and their human context Everything below is what sits behind that. The question about c-cell question that I actually want…	+41	45	24k	12mo
Reverting an edit that had no revision note Meta › Wiki maintenance citation check moderation review date maintainership Posting this under the heading it deserves: Reverting an edit that had no revision note Everything below is what sits behind that. Reverting an edit: setting out the arithmetic in full, because I have had to…	+17	21	4.5k	12mo
Journal club: how we handle discontinuation in obesity trials Evidence › Journal club randomised trial effect size number needed to treat Solved Closed On the subject in the title: Journal club: how we handle discontinuation in obesity trials Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…		2	1.9k	12mo
Second pass at: Sleep tracking data and its considerable limitations Wellbeing › Sleep fatigue heart rate obstructive sleep apnoea Posting this under the heading it deserves: Second pass at: Sleep tracking data and its considerable limitations Everything below is what sits behind that. A measurement question rather than a physiology one.…		2	59	12mo
Counter-ion content and its effect on measured mass Analytics › Mass spectrometry high-resolution MS charge states MALDI-TOF LC-MS Solved On the subject in the title: Counter-ion content and its effect on measured mass Working notes rather than a conclusion. Something about counter-ion content does not reconcile and I would like a second pair…	+100	108	45k	12mo
Biological variation versus analytical imprecision Clinical › Bloodwork lipase & amylase liver enzymes thyroid function HbA1c On the subject in the title: Biological variation versus analytical imprecision Working notes rather than a conclusion. A question about biological variation versus analytical imprecision that I think has a…		2	42k	12mo
Canadian access and provincial variation — one year on Regional › North America FDA compounding insurance Canadian access and provincial variation — one year on Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Canadian access and provincial variation…	+43	47	964	12mo