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1,535 topics · page 36 of 40

Topic	Participants	Replies	Views	Activity
Water content on a certificate and why it changes the arithmetic Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers Closed Water content on a certificate and why it changes the arithmetic — setting out what I have, and where I think it stops being reliable. Water content: setting out the arithmetic in full, because I have had to…	+19	23	24k	14mo
Metformin co-administration and additive GI effects Practice › Interactions insulin hypoglycaemia metformin delayed gastric emptying Metformin co-administration and additive GI effects Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on metformin…	+28	32	2.1k	15mo
Risk-of-bias tools and the judgement they conceal Evidence › Meta-analyses meta-analysis heterogeneity publication bias effect size Wiki Risk-of-bias tools and the judgement they conceal Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin risk-of-bias tools down and I want…	+8	12	21k	11mo
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club risk of bias number needed to treat randomised trial Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Working notes on STEP 1 rather than a conclusion. I would rather…	+118	132	12k	15mo
Reading a rodent study on a secretagogue without over-extrapolating Compounds › Secretagogues & GH axis observational data GHRP class CJC-1295 needs a source Closed Posting this under the heading it deserves: Reading a rodent study on a secretagogue without over-extrapolating Everything below is what sits behind that. Reading a rodent study, and specifically the version…	+50	54	32k	10mo
Guidelines revision: what changed and why — does this still hold? Meta › Announcements trust levels site feedback guidelines moderation Guidelines revision: what changed and why — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. I was wrong about Guidelines revision in a thread…		2	58k	7mo
Excipient function in a licensed injectable — the long version Pharmacology › Formulation chemistry sterile water storage bacteriostatic water Posting this under the heading it deserves: Excipient function in a licensed injectable — the long version Everything below is what sits behind that. A narrow question about Excipient function, deliberately…		2	100	15mo
Follow-up: Documentation that appears only after payment Sourcing › Red flags disputed mislabelling underdosing documentation quality Wiki Posting this under the heading it deserves: Documentation that appears only after payment Everything below is what sits behind that. Proposing that Documentation deserves a maintained page rather than a…	+82	87	50k	14mo
Reflectance and photometric devices: precision in practice Analytics › Home & field testing third-party testing documentation quality LOD & LOQ Solved On the subject in the title: Reflectance and photometric devices: precision in practice Working notes rather than a conclusion. I was wrong about reflectance and photometric devices in a thread last spring…		2	2.2k	10mo
Micronutrient status when intake falls substantially Clinical › Bloodwork lipase & amylase thyroid function lipid panel HbA1c Solved Wiki Closed On the subject in the title: Micronutrient status when intake falls substantially Working notes rather than a conclusion. Posting a small dataset on micronutrient status. It is mine, it is uncontrolled, and…	+26	30	367	11mo
Shakes versus food: a pragmatic assessment — the long version Nutrition & Training › Protein & intake micronutrients fatigue constipation On the subject in the title: Shakes versus food: a pragmatic assessment — the long version Working notes rather than a conclusion. A narrow question about Shakes versus food, deliberately narrow, because the…	+36	41	28k	14mo
Comparing tirzepatide and semaglutide is harder than the tables suggest Compounds › Tirzepatide SURMOUNT programme randomised trial effect size Posting this under the heading it deserves: Comparing tirzepatide and semaglutide is harder than the tables suggest Everything below is what sits behind that. Reading back through what has been written here…		2	3.8k	10mo
Coming back to: Checking someone else's arithmetic: a worked example thread Practice › Reconstitution concentration maths reconstitution bacteriostatic water dead volume Posting this under the heading it deserves: Checking someone else's arithmetic: a worked example thread Everything below is what sits behind that. Practical question with the units stated, because I have seen…	+13	17	293	11mo
Regression to the mean in progress reports Research Methods › Statistics number needed to treat heterogeneity confounding effect size On the subject in the title: Regression to the mean in progress reports Working notes rather than a conclusion. Something about regression does not reconcile and I would like a second pair of eyes before I…	+30	34	49k	12mo
A pen that felt like it delivered nothing: diagnosing it afterwards Devices › Pens & autoinjectors storage subcutaneous injection missed dose dead volume Solved On the subject in the title: A pen that felt like it delivered nothing: diagnosing it afterwards Working notes rather than a conclusion. Question about a metering device rather than about a syringe, because…	+35	39	584	6mo
Relative retention time as a better inter-laboratory comparator Analytics › Method validation linearity recovery precision & repeatability stability-indicating method On the subject in the title: Relative retention time as a better inter-laboratory comparator Working notes rather than a conclusion. What changes if the standard account of relative retention time is wrong? I…	+7	11	28k	14mo
Reading a trial's population section before its results — does this still hold? Evidence › Trials randomised trial open label intention to treat discontinuation & dropout Closed Reading a trial's population section before its results — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Reading STEP 1 ( N Engl J Med , 2021)…	+140	154	5.4k	14mo
Why plausible mechanism is not evidence of effect — one year on Compounds › Repair & healing peptides needs a source preprint BPC-157 Solved Closed The question in the title: Why plausible mechanism is not evidence of effect — one year on I will give what I have already checked below so nobody repeats it. What changes if the standard account of plausible…	+3	7	3.6k	13mo
Vagal afferents and the gut-brain pathway Pharmacology › Receptor biology semaglutide tirzepatide retatrutide long read On the subject in the title: Vagal afferents and the gut-brain pathway Working notes rather than a conclusion. Vagal afferents — I have the observation and I do not trust my interpretation of it, so I am…	+5	9	44k	13mo
Research-use-only status: what it means legally and practically — does this still hold? Compounds › Other compounds custom synthesis mislabelling needs a source research use only Solved Pinned Asking directly, because I could not find a straight answer: Research-use-only status: what it means legally and practically — does this still hold? Asking about Research-use-only status directly, because I…		2	309	9mo
Why oral semaglutide needs an absorption enhancer at all Compounds › Oral incretins randomised trial orforglipron oral semaglutide SOUL trial Solved Why oral semaglutide needs an absorption enhancer at all I have a specific reason for asking rather than idle curiosity, and the context is below. Reading back through what has been written here about oral…	+59	65	61k	7mo
Ipamorelin selectivity claims and where they came from — a second dataset Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin ipamorelin Posting this under the heading it deserves: Ipamorelin selectivity claims and where they came from — a second dataset Everything below is what sits behind that. Posting a small dataset on Ipamorelin…		2	27k	14mo
Reaching a dose and staying there for a year: a longitudinal note Practice › Dosing & titration worked example tirzepatide titration semaglutide Reaching a dose and staying there for a year: a longitudinal note Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a…		2	763	15mo
Journal club: the retatrutide phase 2 obesity paper Evidence › Journal club estimand number needed to treat journal club randomised trial Solved Journal club: the retatrutide phase 2 obesity paper — setting out what I have, and where I think it stops being reliable. Collecting what is known about retatrutide phase 2 obesity paper in one place, because…	+7	11	33k	7mo
Which panel is worth repeating and which is worth ignoring Clinical › Bloodwork eGFR & renal function liver enzymes HbA1c Solved The question in the title: Which panel is worth repeating and which is worth ignoring I will give what I have already checked below so nobody repeats it. An honest uncertainty about panel rather than a…	+125	133	17k	10mo
Validating a calculator against hand arithmetic — what changed since Data & Tools › Calculators concentration maths site feedback worked example Solved Posting this under the heading it deserves: Validating a calculator against hand arithmetic — what changed since Everything below is what sits behind that. What changes if the standard account of Validating a…	+121	137	21k	13mo
Trial registration and comparing the protocol with the paper Evidence › Trials randomised trial open label intention to treat Trial registration and comparing the protocol with the paper — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin trial registration down and I want to…	+38	44	4.8k	10mo
Carryover and the ghost peak from last week's standard Analytics › HPLC & UHPLC data table UV & DAD detection peak integration system suitability On the subject in the title: Carryover and the ghost peak from last week's standard Working notes rather than a conclusion. What changes if the standard account of carryover is wrong? I ask because I have…	+80	92	16k	16mo
Mood changes: monitoring, and when to involve a professional Wellbeing › Mental health mood beginner friendly disordered eating Mood changes: monitoring, and when to involve a professional — setting out what I have, and where I think it stops being reliable. Mood changes — I have the observation and I do not trust my interpretation of…		2	362	13mo
A report I filed that turned out to be wrong, and the correction Sourcing › Vendor reports certificate of analysis disputed third-party testing A report I filed that turned out to be wrong, and the correction Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an opinion, following the…	+124	132	12k	13mo