r.coelho

TL2 Moderator · Bursa

Contributes reviews on supplier material. Based in Bursa.

Joined 8 September 2025 · last posted 16h

98 posts, newest first. Showing up to 150.

Fibre intake when total intake falls, and the constipation link — one year on Replied, post #14 · Nutrition & Training › Protein & intake · 27 Jul 2026 · 0 likes Eating anything at all: on substantial appetite suppression, eating enough total calories to maintain lean mass is the priority. Protein comes second to total intake.
[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #112 · Access › International · 26 Jul 2026 · 0 likes Picking up post #109: that is the part I would want checked first. Travel with medication: carrying a compound across borders is complicated by legal status.…
Here for the analytics and not much else Replied, post #96 · Lounge › Introductions · 26 Jul 2026 · 0 likes Coming back to post #94, because the follow-up matters more than the original answer. Community culture: introductions give you a sense of who is here. Reading a few…
What a certificate commits its issuer to Replied, post #106 · Analytics › COA interpretation · 26 Jul 2026 · 30 likes I read post #104 twice before replying, because I had assumed the opposite. Having read the exchange above, I think I was wrong earlier in this topic and I want to say…
Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #85 · Compounds › Retatrutide · 23 Jul 2026 · 18 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Follow-up: How compounding permissions changed when supply normalised Replied, post #51 · Sourcing › Regulatory · 21 Jul 2026 · 7 likes Primary documents matter: regulatory positions are published in official documents. Reading the regulatory agency's website directly is more reliable than reading a…
Athletes in weight-category sports: a different risk calculus Replied, post #32 · Clinical › Special populations · 19 Jul 2026 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Second pass at: Absence of evidence and evidence of absence Replied, post #49 · Research Methods › Statistics · 19 Jul 2026 · 0 likes Picking up post #46: that is the part I would want checked first. Effect sizes: the magnitude of a difference, not just whether it is statistically significant. A…
Insurance and replacement policies, compared Replied, post #100 · Sourcing › Logistics · 19 Jul 2026 · 10 likes post #99 is right about the mechanism and I think understates the practical bit. Declaring contents accurately: declaring accurately reduces intervention risk. A…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #124 · Evidence › Journal club · 18 Jul 2026 · 5 likes On post #120 — agreed on the reasoning, with one qualification. PIONEER 6 (N Engl J Med 2019): Cardiovascular safety trial for oral semaglutide, not efficacy.…
What steady state means for the decision to escalate Replied, post #28 · Practice › Dosing & titration · 13 Jul 2026 · 29 likes Worth separating two things that post #24 runs together. Dose equivalence between different incretin analogues is a weak concept. The molecules differ in structure,…
Research-use-only status: what it means legally and practically Replied, post #73 · Compounds › Other compounds · 11 Jul 2026 · 27 likes Why catalogue breadth is not evidence of anything: a supplier listing 500 compounds does not make the 450 untested ones likely to work. It makes them untested compounds…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #41 · Analytics › Impurities & related substances · 2 Jul 2026 · 1 like Worth separating two things that post #37 runs together. Aggregates: multiples of the monomer mass. May not elute at all under a standard reversed-phase method. A…
Tracking a shortage from primary sources rather than rumour Replied, post #63 · Access › Shortages · 22 Jun 2026 · 25 likes On post #59 — agreed on the reasoning, with one qualification. Compounding during shortages: some jurisdictions allow pharmacy compounding when a marketed product is in…
Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #82 · Data & Tools › Datasets · 18 Jun 2026 · 6 likes On post #78 — agreed on the reasoning, with one qualification. Community-collected datasets: some members have compiled datasets from their own experience and shared…
Pooling trials with different estimands Replied, post #30 · Evidence › Meta-analyses · 17 Jun 2026 · 2 likes On post #26 — agreed on the reasoning, with one qualification. Study quality and weighting: some meta-analyses weight all studies equally; others weight by study size…
Electrolyte supplements: which ones do anything Replied, post #31 · Nutrition & Training › Hydration & electrolytes · 15 Jun 2026 · 24 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Reconstituting a multi-strength kit without mixing yourself up — what changed since Replied, post #24 · Practice › Reconstitution · 7 Jun 2026 · 0 likes I read post #22 twice before replying, because I had assumed the opposite. Arithmetic step by step: a 5 mg vial with 2 mL of diluent gives (5 mg) / (2 mL) = 2.5 mg/mL.…
Pooling trials with different estimands Started this topic · Evidence › Meta-analyses · 30 May 2026 · 34 likes On the subject in the title: Pooling trials with different estimands Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with SURMOUNT-1 ( N…
Injection volume, overload, and peak distortion Replied, post #26 · Analytics › HPLC & UHPLC · 29 May 2026 · 16 likes Coming back to post #24, because the follow-up matters more than the original answer. Method validation is the demonstration that a method can separate the compound…
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just… Replied, post #85 · Compounds › Tirzepatide · 24 May 2026 · 11 likes I read post #83 twice before replying, because I had assumed the opposite. SURPASS-2 compared tirzepatide with semaglutide 1.0 mg, the licensed diabetes dose at that…
Request: a per-category review queue Replied, post #3 · Meta › Feature requests · 24 May 2026 · 5 likes Coming back to the opening post, because the follow-up matters more than the original answer. Requests for platform and documentation features, with the reasoning that…
The headache that turns out to be dehydration — the long version Replied, post #34 · Nutrition & Training › Hydration & electrolytes · 12 May 2026 · 0 likes post #33 is right about the mechanism and I think understates the practical bit. Lab testing: if symptoms are severe or persistent, checking electrolytes and minerals…
Requesting a translation of an existing page — the long version Replied, post #7 · Documentation › Wiki requests · 8 May 2026 · 3 likes Format suggestions: if you think a maintained page could be clearer in its presentation (different section structure, different examples, added graphics) suggest the…
Why we ask for units every single time, with three examples of what goes wrong — what… Replied, post #4 · Start Here › How to Ask · 6 May 2026 · 19 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Reference intervals: how they are constructed and why one in twenty flags Replied, post #92 · Clinical › Bloodwork · 5 May 2026 · 28 likes Renal function markers: eGFR is estimated, not measured. It depends on creatinine, age, and weight. A small change in creatinine might not mean a real change in kidney…
The "under review" status pill and when a moderator applies it Replied, post #112 · Evidence › Preprints · 3 May 2026 · 18 likes Coming back to post #110, because the follow-up matters more than the original answer. Having read the exchange above, I think I was wrong earlier in this topic and I…
[2026 update] Composite endpoints and the component doing the work Replied, post #76 · Evidence › Trials · 19 Apr 2026 · 8 likes Population narrowness: most trials in this class enrolled fairly specific groups. Baseline body mass index ranges, exclusion of renal disease, exclusion of certain…
Sample handling between despatch and injection Replied, post #46 · Analytics › Method validation · 17 Apr 2026 · 3 likes Picking up post #43: that is the part I would want checked first. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #9 · Devices › Syringes & needles · 6 Apr 2026 · 27 likes Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it…
Reference intervals: how they are constructed and why one in twenty flags Replied, post #71 · Clinical › Bloodwork · 27 Mar 2026 · 0 likes Reference intervals: constructed to contain the central 95% of a reference population, which means one in twenty healthy people falls outside one by definition. Add…
Journal club: SURMOUNT-4 and continuation versus withdrawal Replied, post #12 · Evidence › Journal club · 21 Mar 2026 · 0 likes Coming back to post #10, because the follow-up matters more than the original answer. Having read the exchange above, I think I was wrong earlier in this topic and I…
Whether protein timing matters at a large deficit Replied, post #34 · Nutrition & Training › Protein & intake · 15 Mar 2026 · 1 like This follows post #31 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #140 · Compounds › Semaglutide · 10 Mar 2026 · 7 likes The opalescent appearance in semaglutide solutions is occasionally noted and the mechanism is unclear. It does not appear to correlate with product failure in practice.…
Choosing which test to pay for, given a fixed budget Replied, post #19 · Sourcing › Independent verification · 10 Mar 2026 · 2 likes When results are inconclusive: if a testing service reports "insufficient to verify" on a documentation review, that is not a negative finding about the product. It…
[2026 update] Confounding by indication, explained with a concrete example Replied, post #70 · Evidence › Study critique · 20 Feb 2026 · 0 likes Generalisability: do the inclusion/exclusion criteria narrow the population so much that results do not apply to real people asking about it? This is a fair criticism…
Second pass at: The topic list is dense — is that deliberate? Replied, post #59 · Meta › Site feedback · 31 Jan 2026 · 9 likes post #58 is right about the mechanism and I think understates the practical bit. For anyone arriving from a search: the marked solution above is the direct answer, and…
Second pass at: Choosing a concentration on purpose rather than by accident Started this topic · Practice › Reconstitution · 27 Jan 2026 · 4 likes Second pass at: Choosing a concentration on purpose rather than by accident Writing it up because I had to work it out twice and would rather nobody else did. A…
Revisiting: Language barriers in accessing a prescription abroad Replied, post #67 · Access › International · 21 Jan 2026 · 0 likes Language barriers: if you need to communicate with a supplier, clinician, or regulator in a language not your first language, misunderstanding is possible. Clarify when…
Why a compound being unapproved is not the same as being illegal to possess Replied, post #47 · Sourcing › Regulatory · 6 Jan 2026 · 0 likes Import restrictions vary by compound and by jurisdiction: what is a controlled substance in one place is legal to purchase in another. What you can import for personal…
Preprint servers and what screening they do Replied, post #12 · Evidence › Preprints · 31 Dec 2025 · 28 likes Preprints for speed: some important preliminary findings are posted as preprints to disseminate quickly. That speed is useful but comes at the cost of not yet having…
Vomiting: when it is expected and when it is a reason to stop Replied, post #62 · Practice › Side effects · 28 Dec 2025 · 11 likes Coming back to post #60, because the follow-up matters more than the original answer. Gallbladder complications: rapid weight loss increases the risk of gallstone…
Follow-up: The decimal-point error, and the habit that catches it Replied, post #120 · Practice › Reconstitution · 15 Dec 2025 · 0 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Tracking a preprint to publication: a worked example Replied, post #32 · Evidence › Preprints · 2 Dec 2025 · 19 likes Peer review as a filter: published papers have survived a review process that rejects many submissions. Preprints have not. Neither guarantees correctness, but…
Why "add 2 mL" is not an instruction Replied, post #13 · Practice › Reconstitution · 1 Dec 2025 · 29 likes A 10 mg vial reconstituted three different ways: 1 mL diluent gives 10 mg/mL, 2 mL gives 5 mg/mL, 4 mL gives roughly 2.5 mg/mL. The arithmetic is the same; the…
History of disordered eating and why it changes the conversation Replied, post #25 · Clinical › Special populations · 1 Dec 2025 · 1 like Gastroparesis: pre-existing severe delayed gastric emptying can worsen with compounds that slow it further. Discussion with a clinician is prudent if this history exists.
What a purity-only report leaves out Replied, post #92 · Sourcing › Independent verification · 18 Nov 2025 · 15 likes Picking up post #89: that is the part I would want checked first. Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest…
[2026 update] What steady state means for the decision to escalate Replied, post #17 · Practice › Dosing & titration · 6 Nov 2025 · 5 likes post #16 is right about the mechanism and I think understates the practical bit. Micro-titration: the concept of increments smaller than the labelled steps. It has no…
What a purity-only report leaves out Replied, post #71 · Sourcing › Independent verification · 3 Nov 2025 · 28 likes Worth separating two things that post #67 runs together. Two things before anyone answers the substance. First, the context in the first post is clear and specific.…
Where to report an adverse event officially, by region — a second dataset Replied, post #75 · Safety › Adverse events · 31 Oct 2025 · 1 like Coming back to post #73, because the follow-up matters more than the original answer. Practical note that does not fit anywhere else. Whatever you conclude from this…
A parcel that arrived warm: a decision process, not a verdict Replied, post #109 · Practice › Storage & stability · 29 Oct 2025 · 0 likes Beyond-use dating: the date after which a prepared solution should not be used. It is an estimate based on how fast the solution degrades under stated storage, not on…
A 40-week log with the measurement method stated Replied, post #68 · Outcomes › Progress reports · 25 Oct 2025 · 2 likes I read post #66 twice before replying, because I had assumed the opposite. Non-scale victories: muscle gain or maintenance, clothing fit, energy level, and capability…
Documentation that appears only after payment Replied, post #57 · Sourcing › Red flags · 24 Oct 2025 · 0 likes Documentation quality as a signal: a supplier that reports method identifiers, distinguishes specification from result, and states the counter-ion form is telling you…
Older adults, sarcopenia risk, and the trade-off nobody quantifies Replied, post #17 · Clinical › Special populations · 22 Oct 2025 · 3 likes Medullary thyroid carcinoma history: an absolute contraindication because of the preclinical findings in rodent toxicology. The history (personal or family, especially…
High-resolution MS on aggregates and what it can see Replied, post #99 · Analytics › Mass spectrometry · 21 Oct 2025 · 25 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
How to read a forest plot, properly, from scratch Replied, post #42 · Evidence › Trials · 18 Oct 2025 · 1 like Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Micronutrient adequacy at low total intake — does this still hold? Started this topic · Nutrition & Training › Protein & intake · 2 Oct 2025 · 6 likes Micronutrient adequacy at low total intake — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Longitudinal…
Managing an unplanned gap in supply — what changed since Replied, post #67 · Access › Shortages · 20 Sep 2025 · 7 likes This follows post #64 rather than contradicting it. Compounding during shortages: some jurisdictions allow pharmacy compounding when a marketed product is in shortage.…
Pinch or no pinch, and how needle length changes the answer Replied, post #70 · Practice › Administration · 20 Sep 2025 · 2 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Payment method and the leverage it gives you, ranked Replied, post #29 · Sourcing › Payments · 18 Sep 2025 · 10 likes Refund policy before ordering: ask what the policy is if you receive damaged material or if the order is incorrect. Get it in writing or screenshot it.
Thyroid function tests during substantial weight change Replied, post #57 · Clinical › Bloodwork · 10 Sep 2025 · 28 likes Liver enzymes: elevation does not specify cause. ALT and AST can rise from many things. Bilirubin helps narrow down the cause. Multiple markers together are more…
Second pass at: LOD and LOQ: definitions people get wrong Replied, post #38 · Analytics › Method validation · 8 Sep 2025 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Realistic expectations for strength while losing weight quickly Replied, post #19 · Nutrition & Training › Resistance training · 7 Sep 2025 · 0 likes Intensity: using weights that allow 6 to 12 reps before fatigue is a reasonable range for preserving muscle. Heavier weights with lower reps can work but require more…
A 10 mg vial reconstituted three different ways, compared — the long version Replied, post #111 · Practice › Reconstitution · 23 Aug 2025 · 15 likes How much of the diluent volume the powder itself displaces: for a small peptide vial, the powder volume is negligible. For a larger vial or a kit with multiple…
Follow-up: Why appetite effects are mostly central Replied, post #22 · Pharmacology › Receptor biology · 21 Aug 2025 · 2 likes Bias and desensitisation: receptors can be biased (preferentially activating some downstream pathways over others) and can desensitise over time (responding less to the…
Second pass at: How to ask a question when you cannot say why you are asking it Replied, post #8 · Start Here › How to Ask · 18 Aug 2025 · 6 likes What you have already read matters. Saying "I read the maintained page on this and I still have a gap" tells people they do not need to point you at the same resource…
Enforcement priorities versus written rules — does this still hold? Replied, post #7 · Sourcing › Regulatory · 11 Aug 2025 · 2 likes Picking up post #4: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the replies…
A request that was declined, and the reasoning — a second dataset Replied, post #35 · Documentation › Wiki requests · 9 Aug 2025 · 20 likes Format suggestions: if you think a maintained page could be clearer in its presentation (different section structure, different examples, added graphics) suggest the…
Canadian access and provincial variation — one year on Replied, post #47 · Regional › North America · 29 Jul 2025 · 31 likes Compounding pharmacies: pharmaceutical compounding of a drug not on the FDA shortage list is substantially constrained. The landscape changed when supply normalised.…
Second pass at: Why this subcategory is stricter about sourcing than most Replied, post #9 · Compounds › Secretagogues & GH axis · 24 Jul 2025 · 3 likes Coming back to post #7, because the follow-up matters more than the original answer. Ipamorelin selectivity claims originate in preclinical characterisation and are…
The storage lookup and where its data comes from Replied, post #3 · Data & Tools › Calculators · 10 Jun 2025 · 1 like Titration planning: a calculator that shows you the escalation schedule for different starting and ending doses can help you visualize your path. Actual path might be…
Follow-up: History of disordered eating and why it changes the conversation Replied, post #17 · Clinical › Special populations · 1 Jun 2025 · 15 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Amylin analogue mechanism: satiety signalling separate from GLP-1 Replied, post #123 · Compounds › Cagrilintide & amylin analogues · 27 May 2025 · 0 likes Picking up post #120: that is the part I would want checked first. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the…
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ Replied, post #76 · Sourcing › Independent verification · 10 May 2025 · 0 likes Coming back to post #74, because the follow-up matters more than the original answer. Cost and turnaround: different services have different pricing and turnaround…
Deamidation and the close-eluting pair it produces Replied, post #31 · Analytics › Impurities & related substances · 24 Apr 2025 · 0 likes This follows post #28 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
Follow-up: Requesting a page: what makes a good request Replied, post #18 · Documentation › Wiki requests · 5 Apr 2025 · 0 likes Picking up post #15: that is the part I would want checked first. Cross-referencing: if you notice two pages that should reference each other but do not, suggest the…
A well-designed study with a badly written abstract Started this topic · Evidence › Study critique · 27 Mar 2025 · 26 likes Posting this under the heading it deserves: A well-designed study with a badly written abstract Everything below is what sits behind that. Comparing SCALE ( N Engl J…
Journal club: STEP 4 and what a withdrawal design can prove Replied, post #9 · Evidence › Journal club · 12 Mar 2025 · 15 likes Picking up post #6: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the replies…
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Replied, post #112 · Compounds › Semaglutide · 21 Feb 2025 · 0 likes Semaglutide versus liraglutide in STEP 8: semaglutide produced greater weight reduction and the discontinuation rates differed. But the trial was open-label for the…
Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #3 · Evidence › Journal club · 19 Feb 2025 · 3 likes Picking up post #2: that is the part I would want checked first. Session format: read the paper before posting. The discussion is much better when everyone has. Start…
Why we hide unevidenced fraud accusations and log the hiding Replied, post #54 · Sourcing › Red flags · 18 Feb 2025 · 4 likes Evasion when asked: if a supplier does not clarify when asked specifically for method details, counter-ion form, or batch origin, that itself is a red flag worth…
UK access routes, dated and sourced — a second dataset Replied, post #35 · Regional › UK & Ireland · 5 Feb 2025 · 2 likes On post #31 — agreed on the reasoning, with one qualification. Occupational health screening: some UK occupations require medical checks. Disclosure of weight-loss…
What we do not know about retatrutide, listed explicitly Replied, post #70 · Compounds › Retatrutide · 26 Jan 2025 · 10 likes Triple agonism: is the effect additive, synergistic, or neither? A phase 2 comparison of tirzepatide (dual) to retatrutide (triple) would answer that question. The…
Dose numbers for oral formulations are not comparable to injectable ones — a second… Replied, post #47 · Compounds › Oral incretins · 13 Jan 2025 · 3 likes Fasting instructions are not optional advice. Taking the tablet with food or with more than a sip of water measurably reduces absorption. This is the one compound in…
Molecular mass of semaglutide and why the figure differs between sources — does this… Replied, post #96 · Compounds › Semaglutide · 24 Dec 2024 · 0 likes The STEP programme populations were selected: enrollment criteria required baseline body mass index over 30, no recent blood pressure crisis, no recent retinopathy, no…
[2026 update] How to read a forest plot, properly, from scratch Replied, post #49 · Evidence › Trials · 21 Dec 2024 · 0 likes The estimand: what the trial set out to estimate. Two trials can be identical in structure but estimate different things by using different handling rules for people…
Washout with a one-week half-life: the arithmetic Replied, post #23 · Research Methods › N-of-1 designs · 26 Nov 2024 · 13 likes Objective versus subjective measures: subjective measures (how you feel) are vulnerable to bias. Objective measures (weight, strength on a specific exercise) are less…
Follow-up: Dead volume across syringe and needle combinations Replied, post #70 · Devices › Syringes & needles · 23 Nov 2024 · 0 likes Picking up post #67: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
Reconstituting a multi-strength kit without mixing yourself up Replied, post #5 · Practice › Reconstitution · 23 Nov 2024 · 24 likes On the opening post — agreed on the reasoning, with one qualification. Two things before anyone answers the substance. First, the context in the first post is clear and…
Second pass at: Choosing a concentration on purpose rather than by accident Replied, post #11 · Practice › Reconstitution · 11 Nov 2024 · 9 likes A 10 mg vial reconstituted three different ways: 1 mL diluent gives 10 mg/mL, 2 mL gives 5 mg/mL, 4 mL gives roughly 2.5 mg/mL. The arithmetic is the same; the…
US compounding rules and how they changed Replied, post #60 · Regional › North America · 6 Nov 2024 · 10 likes Cross-border purchase: buying in the US and bringing to Canada or vice versa involves both countries' import rules. The medication is legal but crossing borders with it…
Time to steady state after a dose increase Replied, post #94 · Pharmacology › Pharmacokinetics · 5 Nov 2024 · 0 likes This follows post #91 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #23 · Evidence › Journal club · 3 Nov 2024 · 0 likes SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence to the oral formulation. Note that oral bioavailability is lower…
Why I ask for the gradient before I discuss the number Replied, post #19 · Analytics › HPLC & UHPLC · 10 Sep 2024 · 5 likes Column chemistry and particle size: smaller particles (1.7 μm) give better resolution and higher efficiency than larger particles (3.5 μm or 5 μm), at the cost of…
High-resolution MS on aggregates and what it can see — one year on Replied, post #32 · Analytics › Mass spectrometry · 16 Aug 2024 · 27 likes Sample matrix effects: if a sample is dissolved in a complex matrix, other compounds in the matrix can suppress the peptide signal. Clean samples give higher…
Second pass at: Retatrutide dose escalation in the published trials Replied, post #110 · Compounds › Retatrutide · 23 Jul 2024 · 0 likes Coming back to post #108, because the follow-up matters more than the original answer. Retatrutide is investigational. Anything obtained outside a trial is by…
Second pass at: Retatrutide dose escalation in the published trials Replied, post #82 · Compounds › Retatrutide · 21 Jul 2024 · 1 like Phase 2 sample sizes are not adequate for safety characterisation of a novel triple agonist. Phase 3 is where that question gets answered. Using phase 2 results to make…
Journal club: FLOW and the renal composite, component by component Replied, post #80 · Evidence › Journal club · 17 Jul 2024 · 4 likes SURMOUNT-OSA (N Engl J Med 2024): Tirzepatide in obstructive sleep apnoea, using an objective physiological endpoint. Notable because soft endpoints are avoided. Two…