s.vanhecke

TL2 Moderator · Osijek

Contributes reviews on supplier material. Based in Osijek.

Joined 27 May 2025 · last posted 2d

92 posts, newest first. Showing up to 150.

Reading order for a first week here, and what to skip until later — what changed since Replied, post #87 · Start Here › Welcome · 26 Jul 2026 · 0 likes On post #83 — agreed on the reasoning, with one qualification. Welcome. The orientation materials are pinned at the top of this category and they take about an hour.…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #131 · Evidence › Journal club · 25 Jul 2026 · 8 likes On post #127 — agreed on the reasoning, with one qualification. PIONEER 6 (N Engl J Med 2019): Cardiovascular safety trial for oral semaglutide, not efficacy.…
Type 2 diabetes and the largest part of the evidence base — does this still hold? Replied, post #22 · Clinical › Comorbidities · 22 Jul 2026 · 0 likes post #21 is right about the mechanism and I think understates the practical bit. Comorbidity control: if a comorbidity (high blood pressure, high lipids) is not…
Reading a home test result without over-claiming Replied, post #130 · Analytics › Home & field testing · 22 Jul 2026 · 0 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
What to bring: records that a clinician can actually use — a second dataset Replied, post #59 · Clinical › Prescriber conversations · 21 Jul 2026 · 2 likes post #58 answers the question as asked. The question underneath it is different. Asking about monitoring: understand what lab work will be done, how often, and what you…
Shakes versus food: a pragmatic assessment Replied, post #25 · Nutrition & Training › Protein & intake · 19 Jul 2026 · 2 likes Worth separating two things that post #21 runs together. Timing of protein: spreading protein intake across the day, with some at each meal, is more practical than…
Tracking a shortage from primary sources rather than rumour Replied, post #109 · Access › Shortages · 18 Jul 2026 · 0 likes Compounding during shortages: some jurisdictions allow pharmacy compounding when a marketed product is in shortage. That permission is jurisdiction-specific and…
Transit times by route, from a logged dataset Replied, post #13 · Sourcing › Logistics · 16 Jul 2026 · 11 likes This follows post #10 rather than contradicting it. Tracking stops updating: tracking last updated days ago usually means the package is in transit and will not update…
What a certificate commits its issuer to — one year on Replied, post #101 · Analytics › COA interpretation · 3 Jul 2026 · 29 likes What fields matter on a certificate: lot number matching the vial, test date, the analytical method stated specifically, the measured result as a number, and the…
Follow-up: Reading an interaction checker output critically Replied, post #28 · Practice › Interactions · 2 Jul 2026 · 0 likes post #27 answers the question as asked. The question underneath it is different. Anticoagulants: no direct interaction with the compounds in this class. Weight loss and…
An appeal that succeeded, with the letter structure Replied, post #8 · Access › Insurance & coverage · 11 Jun 2026 · 5 likes On post #4 — agreed on the reasoning, with one qualification. Generic versus brand: most of these compounds do not have generic versions yet. Once they do, formulary…
Micronutrient adequacy at low total intake Replied, post #60 · Nutrition & Training › Protein & intake · 11 Jun 2026 · 9 likes Leucine and MPS: leucine stimulates muscle protein synthesis at a threshold of roughly 2 to 3 grams per meal. That influences how much protein per meal matters, but…
Revisiting: What pooling buys you and what it destroys Replied, post #40 · Evidence › Meta-analyses · 1 Jun 2026 · 0 likes Pooled estimates and heterogeneity: when trials differ in population, duration, or comparator, a pooled estimate answers a question that no individual trial asked. High…
Prescription portability between countries Replied, post #45 · Access › International · 27 May 2026 · 25 likes On post #41 — agreed on the reasoning, with one qualification. Country-by-country legality: compound approval and legal status differ substantially by jurisdiction.…
Pinch or no pinch, and how needle length changes the answer — the long version Replied, post #64 · Practice › Administration · 25 May 2026 · 0 likes I read post #62 twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write…
[2026 update] Storing lyophilised material long term: what governs the shelf life Replied, post #122 · Practice › Storage & stability · 25 May 2026 · 2 likes On post #118 — agreed on the reasoning, with one qualification. Two things before anyone answers the substance. First, the context in the first post is clear and…
Forced degradation studies: designing one that is informative Replied, post #61 · Analytics › Method validation · 23 May 2026 · 0 likes Range: the concentration range over which the method has been validated. Going outside the validated range is going outside the method's demonstrated performance.
MS/MS sequence confirmation: what it costs and when it is worth it Started this topic · Analytics › Mass spectrometry · 20 May 2026 · 24 likes MS/MS sequence confirmation: what it costs and when it is worth it — setting out what I have, and where I think it stops being reliable. I would like to understand what…
Reading a trial's population section before its results Replied, post #33 · Evidence › Trials · 19 May 2026 · 3 likes Open-label design: unblinded trials admit expectation effects. For weight-loss trials where one arm loses substantial weight and the other does not, complete blinding…
Follow-up: A parcel that arrived warm: a decision process, not a verdict Replied, post #33 · Practice › Storage & stability · 19 May 2026 · 4 likes Coming back to post #31, because the follow-up matters more than the original answer. Dating prepared solutions: write the date reconstitution on the vial in permanent…
Why oral semaglutide needs an absorption enhancer at all — one year on Replied, post #13 · Compounds › Oral incretins · 19 May 2026 · 0 likes Why administration conditions matter for oral semaglutide and not for injectables: the oral formulation depends on a transient pH effect in the stomach. Anything that…
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #16 · Compounds › Semaglutide · 4 May 2026 · 3 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
Stepping down deliberately, and how to do it without losing progress Replied, post #103 · Practice › Dosing & titration · 3 May 2026 · 12 likes post #102 is right about the mechanism and I think understates the practical bit. Titrating on tolerability rather than on the calendar: some people escalate when they…
Revisiting: A field-by-field walk through a certificate of analysis Replied, post #11 · Analytics › COA interpretation · 29 Apr 2026 · 9 likes post #10 is right about the mechanism and I think understates the practical bit. Endotoxin testing is separate: a certificate of purity says nothing about endotoxin. A…
MS/MS sequence confirmation: what it costs and when it is worth it — what changed since Replied, post #20 · Analytics › Mass spectrometry · 22 Apr 2026 · 0 likes Charge states observed: for semaglutide (4113.6 Da) the doubly charged ion appears at m/z ≈ 2057, triply charged at ≈ 1371, quadruply at ≈ 1029. Those are the positions…
Subgroup analyses: pre-specified versus discovered — a second dataset Replied, post #48 · Evidence › Trials · 17 Apr 2026 · 7 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
List price versus negotiated price versus what you pay Replied, post #46 · Access › Pricing · 12 Apr 2026 · 0 likes Coming back to post #44, because the follow-up matters more than the original answer. International pricing: the same compound costs very different amounts in different…
GLP-1 receptor distribution: central and peripheral — one year on Replied, post #3 · Pharmacology › Receptor biology · 9 Apr 2026 · 0 likes Glucagon receptor agonism: glucagon receptor agonism increases energy expenditure and promotes hepatic fat oxidation. The mechanism is distinct from GLP-1 and GIP…
[2026 update] 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #17 · Devices › Syringes & needles · 8 Apr 2026 · 0 likes Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a…
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #123 · Access › Pricing · 22 Mar 2026 · 9 likes Price variation between pharmacies: identical prescriptions can cost different amounts at different pharmacies because pharmacies negotiate individually with insurers…
Revisiting: Liver enzymes drifting down and what that usually means Replied, post #13 · Clinical › Bloodwork · 19 Mar 2026 · 7 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Reading a preclinical wound-healing model and its relevance to a human tendon — a second… Replied, post #64 · Compounds › Repair & healing peptides · 14 Mar 2026 · 0 likes Oral versus injected administration claims for BPC-157: the preclinical work studied injection. Oral claims are common in supplier marketing and poorly supported by…
Personal import allowances, compared — a second dataset Replied, post #81 · Access › International · 8 Mar 2026 · 0 likes On post #77 — agreed on the reasoning, with one qualification. Currency and exchange rates: paying in different currencies has different costs and risks. Bitcoin…
Contributing data without breaching anyone's privacy Replied, post #58 · Data & Tools › Datasets · 6 Mar 2026 · 2 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
The 2.5 mg starting dose is not a therapeutic dose — why that matters Replied, post #14 · Compounds › Tirzepatide · 12 Feb 2026 · 0 likes Coming back to post #12, because the follow-up matters more than the original answer. Storage and stability: published data on licensed tirzepatide formulations exists…
Foaming during reconstitution and whether it matters — the long version Replied, post #30 · Practice › Reconstitution · 10 Feb 2026 · 0 likes Picking up post #27: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Replied, post #16 · Analytics › Mass spectrometry · 23 Jan 2026 · 0 likes Quantitation by MS: most quantitation is done by LC-UV detection at 214 nm, not by MS, because extinction coefficients are better known. MS can quantify if an internal…
Anxiety in the first weeks: drug, situation, or both — what changed since Replied, post #73 · Wellbeing › Mental health · 6 Jan 2026 · 28 likes post #72 is right about the mechanism and I think understates the practical bit. Identity and self-image: for some people, weight and body size are central to identity.…
Revisiting: Language barriers in accessing a prescription abroad Replied, post #40 · Access › International · 4 Jan 2026 · 0 likes Language barriers: if you need to communicate with a supplier, clinician, or regulator in a language not your first language, misunderstanding is possible. Clarify when…
Aggregates and why a purity assay may miss them entirely Replied, post #47 · Analytics › Impurities & related substances · 3 Jan 2026 · 0 likes Disulfide formation: if a peptide contains cysteine, it can form disulfide bonds with itself or with other molecules. Under oxidising conditions multiple species…
Coming back to: Private prescribing in the UK: what is actually involved Replied, post #30 · Regional › UK & Ireland · 2 Jan 2026 · 15 likes Compounding pharmacies: UK allows compounding under specific conditions when a licensed product is unavailable. That is not a front-line option but becomes relevant…
Second pass at: Robustness: the parameters worth deliberately varying Replied, post #34 · Analytics › Method validation · 19 Dec 2025 · 3 likes System suitability: injections run at the start of a batch to establish that the instrument and column are performing. Acceptance criteria typically include replicate…
The decimal-point error, and the habit that catches it Replied, post #87 · Practice › Reconstitution · 17 Dec 2025 · 20 likes Reconstituting a multi-strength kit: if a kit contains 5 mg, 10 mg, 15 mg vials and you are reconstituting all of them, writing the concentration on each vial in…
Filter needles: when they help and what they cost you Replied, post #6 · Devices › Syringes & needles · 16 Dec 2025 · 1 like I read post #4 twice before replying, because I had assumed the opposite. Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard),…
Prescription requirements and telehealth models Replied, post #53 · Sourcing › Regulatory · 7 Dec 2025 · 29 likes Compounding and pharmacy rules: some jurisdictions allow a pharmacy to compound a drug that is not on the market under specific conditions. The conditions are strict…
Freeze-thaw and why one cycle is not the same as five Replied, post #21 · Practice › Storage & stability · 10 Nov 2025 · 10 likes Protecting from light: amber vials or opaque containers reduce light exposure. If you are storing for long periods and light matters, this is worth doing. For…
Tracking that stops updating and then resumes Replied, post #39 · Sourcing › Logistics · 25 Oct 2025 · 1 like Import restrictions by jurisdiction: what is legal to import for personal use varies enormously by country. Some jurisdictions are quite permissive; others are not.…
What happens after your first post: likes, trust levels, and why none of it matters much… Replied, post #118 · Start Here › Welcome · 23 Oct 2025 · 10 likes Picking up post #115: that is the part I would want checked first. The compound and evidence pages are updated regularly and they are worth reading when you are new.…
Journal club: STEP-HFpEF and symptom endpoints — a second dataset Replied, post #11 · Evidence › Journal club · 14 Sep 2025 · 28 likes Worth separating two things that post #7 runs together. TRIUMPH (ongoing): Retatrutide phase 3. No results yet. Nothing should be attributed to it because it has not…
Adolescents: a distinct evidence base — one year on Replied, post #16 · Clinical › Special populations · 13 Sep 2025 · 2 likes Picking up post #13: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
Follow-up: Why appetite effects are mostly central Replied, post #37 · Pharmacology › Receptor biology · 10 Sep 2025 · 1 like On post #33 — agreed on the reasoning, with one qualification. Cross-reactivity and selectivity: the compounds are not perfectly selective for their target receptors.…
Reading a combination trial: attributing effect to components Replied, post #4 · Compounds › Cagrilintide & amylin analogues · 19 Aug 2025 · 4 likes Worth separating two things that post #3 runs together. Is synergy the right word for the combination data? A phase 2 trial cannot establish whether effects are…
Coming back to: Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #119 · Compounds › Semaglutide · 14 Aug 2025 · 26 likes On alcohol: the labelling does not contraindicate it, but it raises gastric irritation risk and semaglutide already does that. There is no published interaction study…
Journal club: the retatrutide phase 2 obesity paper Replied, post #5 · Evidence › Journal club · 7 Aug 2025 · 7 likes I read post #3 twice before replying, because I had assumed the opposite. SELECT (N Engl J Med 2023): Semaglutide cardiovascular outcomes without diabetes. The first…
How to ask about something you suspect is a bad idea Started this topic · Start Here › How to Ask · 3 Aug 2025 · 21 likes The question in the title: How to ask about something you suspect is a bad idea I will give what I have already checked below so nobody repeats it. Question in the…
Follow-up: Why we hide unevidenced fraud accusations and log the hiding Replied, post #6 · Sourcing › Red flags · 22 Jul 2025 · 9 likes Pricing patterns: unusually low prices for what are otherwise consistent with market rates might indicate lower quality, stolen goods, or a scam. Unusually high prices…
[2026 update] What we do not know about retatrutide, listed explicitly Replied, post #18 · Compounds › Retatrutide · 21 Jul 2025 · 26 likes The phase 2 obesity paper reported dose-dependent weight reduction of a magnitude that attracted attention. It also reported dose-dependent heart-rate increases. The…
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #61 · Compounds › Oral incretins · 9 Jul 2025 · 10 likes post #60 is right about the mechanism and I think understates the practical bit. Why an oral formulation is a formulation achievement: the molecule is the same but the…
Coming back to: Nausea profile of amylin analogues compared with GLP-1 agonists Replied, post #12 · Compounds › Cagrilintide & amylin analogues · 6 Jul 2025 · 19 likes Historical amylin analogues: pramlintide was the only long-acting amylin analogue licensed for some time and its poor adherence was a known limitation. A weekly…
Coming back to: The SOUL trial and oral semaglutide cardiovascular outcomes Replied, post #11 · Compounds › Oral incretins · 21 Jun 2025 · 2 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Needle changes between doses on a reusable pen Replied, post #14 · Devices › Pens & autoinjectors · 13 Jun 2025 · 0 likes post #13 is right about the mechanism and I think understates the practical bit. Dose counters: pens show the remaining number of doses. When the counter reaches zero,…
Pre-registering a personal experiment, seriously Replied, post #36 · Research Methods › N-of-1 designs · 28 May 2025 · 28 likes Confounding in personal experiments: other things change when you start a medication (season, exercise, diet, stress). Documenting those confounders helps you…
Asking about a compound your prescriber has not heard of Replied, post #49 · Clinical › Prescriber conversations · 26 May 2025 · 0 likes Coming back to post #47, because the follow-up matters more than the original answer. Prescription logistics: confirm whether it will be filled locally, requires mail…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #115 · Practice › Reconstitution · 24 May 2025 · 11 likes How much of the diluent volume the powder itself displaces: for a small peptide vial, the powder volume is negligible. For a larger vial or a kit with multiple…
Follow-up: Why the titration planner refuses to produce a schedule below a floor Replied, post #7 · Data & Tools › Calculators · 20 May 2025 · 3 likes Titration planning: a calculator that shows you the escalation schedule for different starting and ending doses can help you visualize your path. Actual path might be…
Units, standards, and other things that quietly hold the world together Replied, post #36 · Lounge › Off topic · 4 May 2025 · 0 likes On post #32 — agreed on the reasoning, with one qualification. Community norms: if you want to discuss how the community should work (not moderation decisions, which go…
Metformin co-administration and additive GI effects Replied, post #32 · Practice › Interactions · 4 May 2025 · 26 likes Coming back to post #30, because the follow-up matters more than the original answer. Two things before anyone answers the substance. First, the context in the first…
Review: a draft on reconstitution arithmetic, with objections Replied, post #122 · Documentation › Doc review · 24 Apr 2025 · 3 likes Coming back to post #120, because the follow-up matters more than the original answer. Citation checking: if a maintained page cites a paper, the citation should match…
Requesting a page: what makes a good request Replied, post #62 · Documentation › Wiki requests · 18 Apr 2025 · 1 like Format suggestions: if you think a maintained page could be clearer in its presentation (different section structure, different examples, added graphics) suggest the…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #28 · Evidence › Journal club · 18 Apr 2025 · 7 likes Coming back to post #26, because the follow-up matters more than the original answer. TRIUMPH (ongoing): Retatrutide phase 3. No results yet. Nothing should be…
Retatrutide phase 2 in type 2 diabetes: the Lancet paper Started this topic · Compounds › Retatrutide · 26 Mar 2025 · 5 likes On the subject in the title: Retatrutide phase 2 in type 2 diabetes: the Lancet paper Working notes rather than a conclusion. I have seen STEP 2 ( Lancet , 2021) cited…
Adjudicated events and why the definition matters — the long version Replied, post #59 · Evidence › Trials · 22 Mar 2025 · 0 likes post #58 answers the question as asked. The question underneath it is different. The estimand: what the trial set out to estimate. Two trials can be identical in…
About the Red flags category Replied, post #4 · Sourcing › Red flags · 3 Mar 2025 · 0 likes Suggestion for the wiki post above: it would be worth linking the two or three most-referenced topics in this category directly, since new members reliably ask for…
Counter-ion form: the field almost nobody reports — one year on Replied, post #38 · Analytics › COA interpretation · 1 Mar 2025 · 5 likes post #37 is right about the mechanism and I think understates the practical bit. Sterility testing is separate: chromatographic purity, mass spectrometry, and endotoxin…
Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #107 · Evidence › Meta-analyses · 13 Feb 2025 · 27 likes Worth separating two things that post #103 runs together. Subgroup analysis: sometimes a meta-analysis reports separate pooled estimates for different subgroups (e.g.,…
Reading a supplementary appendix and finding the interesting part Replied, post #89 · Evidence › Trials · 10 Feb 2025 · 0 likes The estimand: what the trial set out to estimate. Two trials can be identical in structure but estimate different things by using different handling rules for people…
Second pass at: Obstructive sleep apnoea and a hard endpoint in this class Started this topic · Clinical › Comorbidities · 9 Feb 2025 · 4 likes Second pass at: Obstructive sleep apnoea and a hard endpoint in this class — setting out what I have, and where I think it stops being reliable. Asking about a…
Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #41 · Evidence › Meta-analyses · 2 Feb 2025 · 0 likes When a meta-analysis is unhelpful: if the included studies are heterogeneous in population, intervention, or outcome, pooling them produces a number that represents…
Fixed versus detachable needles: the trade-offs Replied, post #106 · Devices › Syringes & needles · 11 Jan 2025 · 20 likes Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged…
Recovery when intake is low: what to cut first Replied, post #36 · Nutrition & Training › Resistance training · 11 Jan 2025 · 7 likes I read post #34 twice before replying, because I had assumed the opposite. Maintenance is the goal: preserving lean mass and strength during weight loss is the goal of…
Coming back to: When to suspect the method rather than the sample Replied, post #134 · Analytics › Method validation · 25 Dec 2024 · 3 likes Picking up post #131: that is the part I would want checked first. Accuracy: the method measures what you intend to measure. For purity methods, this is tested by…
Why pulsatile secretion matters for interpreting secretagogue claims — a second dataset Replied, post #29 · Compounds › Secretagogues & GH axis · 16 Dec 2024 · 3 likes Tesamorelin has an approved indication in HIV-associated lipodystrophy. That is the only compound in this class with a registration-quality evidence base from a proper…
Coming back to: An 18-month record including the parts that went badly Started this topic · Outcomes › Progress reports · 15 Dec 2024 · 4 likes Posting this under the heading it deserves: An 18-month record including the parts that went badly Everything below is what sits behind that. Longitudinal report with…
Promotion criteria, and the one that stops most nominations Replied, post #139 · Documentation › Doc review · 13 Dec 2024 · 19 likes I read post #137 twice before replying, because I had assumed the opposite. Revision disputes: if you disagree with an edit a maintainer made to a page, discuss it…
Type 1 diabetes: off-label use and the evidence gap — what changed since Replied, post #62 · Clinical › Special populations · 24 Nov 2024 · 29 likes Disordered eating history: a history of anorexia nervosa, bulimia, or other eating disorders changes the risk-benefit calculation because appetite suppression might…
Second pass at: Hoarding and why it makes a shortage worse Replied, post #7 · Access › Shortages · 8 Oct 2024 · 20 likes I read post #5 twice before replying, because I had assumed the opposite. Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and…
Revisiting: Five questions in one post gets you one answer — how to split them Replied, post #4 · marked as the solution · Start Here › How to Ask · 5 Oct 2024 · 9 likes Disagreeing with an answer you got: cite what you disagree with, say what contradicts it, and ask which one holds. Do not open with "I think you are wrong". Lead with…
Why we hide unevidenced fraud accusations and log the hiding Replied, post #2 · Sourcing › Red flags · 28 Sep 2024 · 5 likes Pricing patterns: unusually low prices for what are otherwise consistent with market rates might indicate lower quality, stolen goods, or a scam. Unusually high prices…
Hepatic effects of glucagon receptor agonism: the mechanistic worry Replied, post #16 · Compounds › Retatrutide · 3 Sep 2024 · 0 likes What we do not know about retatrutide, listed explicitly: long-term safety, real-world response rates, the dose response in diverse populations, whether the heart-rate…
Circumference measurements as a poor man's composition estimate Replied, post #102 · Outcomes › Body composition · 27 Aug 2024 · 22 likes post #101 answers the question as asked. The question underneath it is different. Bioelectric impedance analysis: less precise than DXA and strongly affected by…
Circumference measurements as a poor man's composition estimate Replied, post #89 · Outcomes › Body composition · 22 Aug 2024 · 0 likes Precision versus accuracy: the precision you need depends on what question you are answering. "Am I losing fat?" requires less precision than "Is my lean mass…
Reporting a discrepancy without making an allegation Replied, post #34 · Sourcing › Vendor reports · 19 Aug 2024 · 6 likes Temporal patterns: if results from a supplier were good two years ago but have deteriorated recently, that is information. If they have been consistent over years, that…