Latest topics page 25

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 25 of 52

Topic	Participants	Replies	Views	Activity
Older adults, sarcopenia risk, and the trade-off nobody quantifies Clinical › Special populations chronic kidney disease bariatric surgery history older adults pregnancy & planning Older adults, sarcopenia risk, and the trade-off nobody quantifies — setting out what I have, and where I think it stops being reliable. Older adults: setting out the arithmetic in full, because I have had to…	+103	109	12k	5mo
Non-inferiority margins: how they are chosen and how they are abused — a second dataset Evidence › Trials randomised trial discontinuation & dropout intention to treat estimand Non-inferiority margins: how they are chosen and how they are abused — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Non-inferiority…	+32	37	574	5mo
Cardiovascular risk: reading the outcome trials as a set Clinical › Comorbidities MASH / hepatic steatosis chronic kidney disease type 2 diabetes obstructive sleep apnoea Cardiovascular risk: reading the outcome trials as a set Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here about cardiovascular…		4	12k	5mo
Anxiety in the first weeks: drug, situation, or both — what changed since Wellbeing › Mental health mood disordered eating beginner friendly Anxiety in the first weeks: drug, situation, or both — what changed since Writing it up because I had to work it out twice and would rather nobody else did. The question about Anxiety that I actually want…	+88	95	4.5k	5mo
Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Analytics › Method validation LOD & LOQ system suitability linearity stability-indicating method Asking directly, because I could not find a straight answer: Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Posting the method first, because I know what the first three…	+10	14	13k	5mo
Revisiting: What SELECT changed about how semaglutide is discussed, and what it did not Compounds › Semaglutide semaglutide effect size STEP programme randomised trial Solved Revisiting: What SELECT changed about how semaglutide is discussed, and what it did not Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about SELECT in a thread…		2	1.9k	5mo
An ABAB design with a data table and honest limitations Research Methods › N-of-1 designs effect size confounding worked example An ABAB design with a data table and honest limitations Writing it up because I had to work it out twice and would rather nobody else did. An honest uncertainty about ABAB design rather than a disguised…		2	45k	5mo
[2026 update] Reading a supplementary appendix and finding the interesting part Evidence › Trials estimand intention to treat open label surrogate endpoints On the subject in the title: Reading a supplementary appendix and finding the interesting part Working notes rather than a conclusion. Collecting what is known about Reading a supplementary appendix in one…	+39	44	8.2k	5mo
Why "dose equivalence" between different incretin analogues is a weak concept Practice › Dosing & titration tirzepatide dose reduction titration semaglutide Solved Why "dose equivalence" between different incretin analogues is a weak concept I have a specific reason for asking rather than idle curiosity, and the context is below. I have read the maintained page on this…	+124	133	11k	5mo
[2026 update] A rising related-substance total over six months: degradation or method drift? Analytics › Impurities & related substances forced degradation water content endotoxin testing HPLC Solved Wiki The question in the title: A rising related-substance total over six months: degradation or method drift? I will give what I have already checked below so nobody repeats it. Posting the method first, because…	+71	78	34k	5mo
Revisiting: Absolute versus relative contraindications Safety › Contraindications disordered eating pregnancy & planning pancreatitis delayed gastric emptying Revisiting: Absolute versus relative contraindications Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about Absolute versus relative contraindications in a…	+11	15	22k	5mo
Seven-day rolling means and why weekly readings mislead — one year on Outcomes › Progress reports DXA data table long read Solved On the subject in the title: Seven-day rolling means and why weekly readings mislead — one year on Working notes rather than a conclusion. Asking about Seven-day rolling directly, because I have read four…	+78	88	16k	5mo
Tag proliferation and whether we should prune — what changed since Meta › Site feedback site feedback guidelines moderation Tag proliferation and whether we should prune — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Tag proliferation is wrong? I…	+5	9	709	5mo
Mass error in ppm: the arithmetic and the caveat Analytics › Mass spectrometry LC-MS high-resolution MS MALDI-TOF counter-ion content Solved Mass error in ppm: the arithmetic and the caveat Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+108	125	1.5k	5mo
[2026 update] Long-time reader, first-time poster Lounge › Introductions onboarding beginner friendly Solved Long-time reader, first-time poster — setting out what I have, and where I think it stops being reliable. Saying hello, and stating my interest so that it is on the record rather than inferred. I am here for…	+46	50	23k	5mo
Non-inferiority margins: how they are chosen and how they are abused Evidence › Trials open label surrogate endpoints estimand intention to treat Posting this under the heading it deserves: Non-inferiority margins: how they are chosen and how they are abused Everything below is what sits behind that. A question about non-inferiority margins that I…	+42	46	10k	5mo
Coverage in the US: a map of the usual obstacles Regional › North America FDA insurance telehealth compounding Coverage in the US: a map of the usual obstacles — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on coverage. The general claim is fine; I…	+46	50	7.9k	5mo
Storing in the door of the fridge is worse than you think Practice › Storage & stability cold chain beyond-use date storage freeze-thaw Solved Storing in the door of the fridge is worse than you think Writing it up because I had to work it out twice and would rather nobody else did. Asking about the failure mode rather than the procedure, because…		2	8.3k	5mo
What I would record differently if I started again — the long version Outcomes › Progress reports effect size data table DXA Solved Closed What I would record differently if I started again — the long version I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about the phase almost nobody writes…	+22	26	57k	5mo
Filter needles: when they help and what they cost you Devices › Syringes & needles needle gauge & length subcutaneous injection dead volume On the subject in the title: Filter needles: when they help and what they cost you Working notes rather than a conclusion. Trying to work out what would count as evidence on filter needles, before collecting…	+45	50	19k	5mo
Trifluoroacetate content and its consequences Analytics › Impurities & related substances water content data table forced degradation counter-ion content Trifluoroacetate content and its consequences — setting out what I have, and where I think it stops being reliable. What changes if the standard account of trifluoroacetate content is wrong? I ask because I…	+123	134	31k	5mo
Adsorption to container surfaces and to plastics Pharmacology › Formulation chemistry cloudy or discoloured solution counter-ion content sterile water bacteriostatic water On the subject in the title: Adsorption to container surfaces and to plastics Working notes rather than a conclusion. I was wrong about adsorption in a thread last spring and I would like to correct it…	+13	17	4.3k	5mo
Revisiting: Review: an evidence digest and the citation check that delayed it Documentation › Doc review citation check review date maintainership Solved Closed Revisiting: Review: an evidence digest and the citation check that delayed it — setting out what I have, and where I think it stops being reliable. Proposing that evidence digest deserves a maintained page…	+54	58	8.2k	5mo
Coming back to: Pen dose counters: what a click does and does not guarantee Devices › Pens & autoinjectors storage subcutaneous injection dead volume Pen dose counters: what a click does and does not guarantee — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about Pen dose counters, three…		4	105	5mo
Can a home kit substitute for a laboratory report? A careful no Analytics › Home & field testing third-party testing documentation quality LOD & LOQ ELISA Solved Asking directly, because I could not find a straight answer: Can a home kit substitute for a laboratory report? A careful no I would like to disagree carefully with the settled view on home kit substitute,…	+122	131	1.7k	5mo
Heterogeneity as information rather than as a nuisance Evidence › Meta-analyses heterogeneity risk of bias meta-analysis effect size Posting this under the heading it deserves: Heterogeneity as information rather than as a nuisance Everything below is what sits behind that. An honest uncertainty about heterogeneity rather than a disguised…	+88	95	1.2k	6mo
Distinguishing a red flag from an inconvenience Sourcing › Red flags mislabelling documentation quality moderation underdosing Solved Distinguishing a red flag from an inconvenience — setting out what I have, and where I think it stops being reliable. Something about distinguishing a red flag does not reconcile and I would like a second…		2	38k	6mo
Coming back to: Reconstitution volumes that produce round numbers, tabulated Practice › Reconstitution concentration maths syringe units bacteriostatic water dead volume On the subject in the title: Reconstitution volumes that produce round numbers, tabulated Working notes rather than a conclusion. Writing this out with the numbers in it, because "roughly" is how these go…		2	24k	6mo
Follow-up: A supplier that answers analytical questions with restated claims Sourcing › Red flags documentation quality disputed mislabelling moderation A supplier that answers analytical questions with restated claims — setting out what I have, and where I think it stops being reliable. A follow-up question about supplier that I did not know to ask the first…	+74	82	2.8k	6mo
When to stop reading forums, including this one Wellbeing › Mental health mood disordered eating beginner friendly When to stop reading forums, including this one I have a specific reason for asking rather than idle curiosity, and the context is below. Something that has come up for me and that I suspect is more common…	+78	86	47k	6mo