Latest topics page 44
Topics ordered by most recent activity across all 71 subcategories.
1,535 topics · page 44 of 52
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Follow-up: Open-label extensions: what survives and what does not
Open-label extensions: what survives and what does not — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin Open-label extensions down and I want to set…
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+22 | 26 | 397 | 16mo |
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A promotion I argued against, and why I lost
Posting this under the heading it deserves: A promotion I argued against, and why I lost Everything below is what sits behind that. Two things I would like separated before anyone answers on promotion,…
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+148 | 162 | 3.9k | 16mo |
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Preservatives: function, testing, and limits
Preservatives: function, testing, and limits — setting out what I have, and where I think it stops being reliable. An honest uncertainty about preservatives rather than a disguised assertion. I do not know…
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+23 | 27 | 3.7k | 16mo |
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Why cagrilintide alone is discussed so much less than in combination
Why cagrilintide alone is discussed so much less than in combination I have a specific reason for asking rather than idle curiosity, and the context is below. Collecting what is known about cagrilintide alone…
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+93 | 108 | 35k | 16mo |
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What the published dose-response for semaglutide actually looks like above 2.4 mg — a second dataset
Asking directly, because I could not find a straight answer: What the published dose-response for semaglutide actually looks like above 2.4 mg — a second dataset Two things I would like separated before…
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+112 | 130 | 2.2k | 16mo |
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Documenting a supplier's response to a discrepancy — does this still hold?
Documenting a supplier's response to a discrepancy — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Structured question about turnaround and…
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+47 | 52 | 58k | 16mo |
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Second pass at: A single out-of-range value on an otherwise normal panel
Second pass at: A single out-of-range value on an otherwise normal panel Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my…
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+9 | 13 | 8.5k | 16mo |
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Journal club: SUSTAIN 6 and its retinopathy signal — does this still hold?
The question in the title: Journal club: SUSTAIN 6 and its retinopathy signal — does this still hold? I will give what I have already checked below so nobody repeats it. Reading SUSTAIN 6 ( N Engl J Med ,…
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+60 | 66 | 12k | 16mo |
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Second pass at: Cross-border purchase within the EU: the actual rules
Posting this under the heading it deserves: Second pass at: Cross-border purchase within the EU: the actual rules Everything below is what sits behind that. The question about Cross-border purchase within…
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+135 | 139 | 8.7k | 16mo |
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What happens after your first post: likes, trust levels, and why none of it matters much
Asking directly, because I could not find a straight answer: What happens after your first post: likes, trust levels, and why none of it matters much I want to check my reasoning rather than get a conclusion.…
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+15 | 19 | 17k | 16mo |
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Pancreatitis history and the risk calculus — a second dataset
Pancreatitis history and the risk calculus — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Pancreatitis history. It is mine, it…
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+24 | 28 | 36k | 16mo |
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Patterns that reliably precede a problem, documented
Patterns that reliably precede a problem, documented — setting out what I have, and where I think it stops being reliable. Patterns, from the point of view of someone who has read the documentation and is…
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+3 | 7 | 31k | 16mo |
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Counter-ion form: the field almost nobody reports — one year on
On the subject in the title: Counter-ion form: the field almost nobody reports — one year on Working notes rather than a conclusion. The question about Counter-ion form that I actually want answered is the…
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+121 | 139 | 31k | 16mo |
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Coverage for the indication versus for the drug — a second dataset
On the subject in the title: Coverage for the indication versus for the drug — a second dataset Working notes rather than a conclusion. Posting a small dataset on Coverage. It is mine, it is uncontrolled, and…
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+46 | 50 | 41k | 16mo |
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Assessing a warm arrival: the decision process
Posting this under the heading it deserves: Assessing a warm arrival: the decision process Everything below is what sits behind that. A question about assessing a warm arrival that I think has a definite…
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+15 | 19 | 3.3k | 16mo |
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Coming back to: Column chemistry choices for a 40-residue peptide
On the subject in the title: Column chemistry choices for a 40-residue peptide Working notes rather than a conclusion. Column chemistry choices — I have the observation and I do not trust my interpretation of…
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2 | 43k | 16mo | |
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Second pass at: Manufacturer assistance programmes and their eligibility rules
Second pass at: Manufacturer assistance programmes and their eligibility rules — setting out what I have, and where I think it stops being reliable. Two things I would like separated before anyone answers on…
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+13 | 17 | 1.8k | 16mo |
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Research-use-only status: what it means legally and practically — a second dataset
Research-use-only status: what it means legally and practically — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Research-use-only status. It…
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+109 | 125 | 2k | 16mo |
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How compounding permissions changed when supply normalised
Asking directly, because I could not find a straight answer: How compounding permissions changed when supply normalised I was wrong about compounding permissions in a thread last spring and I would like to…
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+30 | 34 | 51k | 16mo |
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Second pass at: Domestic fridge temperature mapping: a cheap experiment
Posting this under the heading it deserves: Second pass at: Domestic fridge temperature mapping: a cheap experiment Everything below is what sits behind that. Two things I would like separated before anyone…
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2 | 30k | 16mo | |
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Oxidation and deamidation mass shifts, tabulated
Posting this under the heading it deserves: Oxidation and deamidation mass shifts, tabulated Everything below is what sits behind that. Oxidation and deamidation mass shifts, and specifically the version of…
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+67 | 76 | 21k | 16mo |
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Validating a method you did not develop — does this still hold?
Validating a method you did not develop — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Validating a method, and specifically the version of…
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+128 | 148 | 47k | 16mo |
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Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since
Posting this under the heading it deserves: Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Everything below is what sits behind that. Putting the numbers in the first…
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+125 | 132 | 39k | 16mo |
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Biased agonism: a real phenomenon, an over-used explanation
Posting this under the heading it deserves: Biased agonism: a real phenomenon, an over-used explanation Everything below is what sits behind that. Trying to work out what would count as evidence on biased…
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+130 | 135 | 23k | 16mo |
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Introducing myself and asking whether my planned first topic belongs anywhere
Introducing myself and asking whether my planned first topic belongs anywhere Writing it up because I had to work it out twice and would rather nobody else did. Checking my reasoning rather than asking for a…
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+13 | 18 | 4.2k | 16mo |
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Maintainer handover: how it works
On the subject in the title: Maintainer handover: how it works Working notes rather than a conclusion. I would like to disagree carefully with the settled view on maintainer handover, and I would like to be…
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+76 | 82 | 14k | 16mo |
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One lot is one lot: when a report becomes a pattern — the long version
One lot is one lot: when a report becomes a pattern — the long version — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the…
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+137 | 152 | 46k | 16mo |
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Journal club: SURMOUNT-OSA and a hard endpoint in a soft field
Posting this under the heading it deserves: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Everything below is what sits behind that. Collecting what is known about SURMOUNT-OSA in one place,…
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+47 | 51 | 617 | 16mo |
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Charge states for a 4 kDa peptide, worked through
On the subject in the title: Charge states for a 4 kDa peptide, worked through Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. retatrutide has a…
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+124 | 146 | 15k | 16mo |
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SNAC and the mechanism of oral peptide absorption — the long version
SNAC and the mechanism of oral peptide absorption — the long version Writing it up because I had to work it out twice and would rather nobody else did. Question about what the published evidence for this…
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+32 | 36 | 6.8k | 16mo |