Ranked by engagement

Top topics — all time page 7

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 7 of 40

Topic	Participants	Replies	Views	Activity
Reverse causation in a cohort study of weight and outcome — a second dataset Evidence › Study critique risk of bias observational data confounding Reverse causation in a cohort study of weight and outcome — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+112	131	1.5k	10mo
Half-life, steady state, and accumulation worked through — a second dataset Pharmacology › Pharmacokinetics semaglutide worked example liraglutide Half-life, steady state, and accumulation worked through — a second dataset — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it…	+110	126	14k	4mo
[2026 update] Cardiovascular risk: reading the outcome trials as a set Clinical › Comorbidities PCOS type 2 diabetes chronic kidney disease blood pressure Posting this under the heading it deserves: Cardiovascular risk: reading the outcome trials as a set Everything below is what sits behind that. Asking about a population rather than about a person. The…	+99	103	32k	11mo
Coming back to: Time to steady state after a dose increase Pharmacology › Pharmacokinetics semaglutide missed dose liraglutide worked example Time to steady state after a dose increase Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+104	110	16k	2d
Pooling trials with different estimands Evidence › Meta-analyses publication bias risk of bias effect size meta-analysis Solved On the subject in the title: Pooling trials with different estimands Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with SURMOUNT-1 ( N Engl J Med , 2022) and finding the…	+120	132	2.3k	1d
BPC-157: what the rodent literature actually shows, and what it does not — a second dataset Compounds › Repair & healing peptides TB-500 preprint observational data needs a source Solved On the subject in the title: BPC-157: what the rodent literature actually shows, and what it does not — a second dataset Working notes rather than a conclusion. I have seen PIONEER 6 ( N Engl J Med , 2019)…	+77	84	54k	11mo
Body image changing more slowly than the body Wellbeing › Mental health beginner friendly disordered eating mood Body image changing more slowly than the body — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this class…	+118	136	1.5k	19mo
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just differently reported? Compounds › Tirzepatide tirzepatide SURMOUNT programme effect size randomised trial Solved Tirzepatide and nausea: is the profile genuinely different or just differently reported? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing STEP 1 ( N Engl J…	+109	122	3.6k	2mo
Forced degradation studies: designing one that is informative Analytics › Method validation precision & repeatability recovery stability-indicating method Under review Posting this under the heading it deserves: Forced degradation studies: designing one that is informative Everything below is what sits behind that. Working through the identity arithmetic and I would like it…	+100	106	35k	2d
Payment method and the leverage it gives you, ranked Sourcing › Payments research use only payments documentation quality Solved Closed Posting this under the heading it deserves: Payment method and the leverage it gives you, ranked Everything below is what sits behind that. Structured report rather than an opinion, following the format the…	+71	76	56k	10mo
Why cagrilintide alone is discussed so much less than in combination Compounds › Cagrilintide & amylin analogues effect size amylin analogues cagrisema Solved Closed Why cagrilintide alone is discussed so much less than in combination I have a specific reason for asking rather than idle curiosity, and the context is below. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+93	108	35k	16mo
Revisiting: Bug report: the reconstitution calculator and a rounding edge case Data & Tools › Calculators worked example site feedback syringe units Revisiting: Bug report: the reconstitution calculator and a rounding edge case — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it…	+109	122	5.8k	17mo
Review: a draft on reconstitution arithmetic, with objections Documentation › Doc review wiki post promoted to docs citation check Review: a draft on reconstitution arithmetic, with objections Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation…	+120	129	4.1k	15mo
Anaesthesia and elective surgery: the aspiration question Practice › Interactions metformin insulin delayed gastric emptying hypoglycaemia Posting this under the heading it deserves: Anaesthesia and elective surgery: the aspiration question Everything below is what sits behind that. A question about technique rather than about dose. I have been…	+103	115	6.6k	3mo
A ten-fold dose error caught before injection Devices › Syringes & needles needle gauge & length worked example syringe units dead volume Closed A ten-fold dose error caught before injection — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern is useful to anyone…	+95	103	26k	10mo
Cagrilintide's dosing interval and the pharmacokinetics behind it Compounds › Cagrilintide & amylin analogues effect size randomised trial amylin analogues cagrisema Solved Cagrilintide's dosing interval and the pharmacokinetics behind it — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SELECT ( N Engl J Med ,…	+98	105	24k	10mo
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Compounds › Semaglutide STEP programme type 2 diabetes randomised trial SELECT trial Posting this under the heading it deserves: Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Everything below is what sits behind that. I have seen SCALE ( N Engl J Med…	+115	122	2.6k	1d
Why the titration planner refuses to produce a schedule below a floor Data & Tools › Calculators syringe units site feedback concentration maths Solved Asking directly, because I could not find a straight answer: Why the titration planner refuses to produce a schedule below a floor I would like to understand what this number means before I repeat it…	+76	83	53k	2mo
Spike-and-recover accuracy for a peptide assay Analytics › Method validation linearity system suitability stability-indicating method LOD & LOQ Wiki Posting this under the heading it deserves: Spike-and-recover accuracy for a peptide assay Everything below is what sits behind that. A documentation question rather than an analytical one. I have a…	+121	126	1.5k	4mo
The topic list is dense — is that deliberate? Meta › Site feedback guidelines site feedback moderation Solved The topic list is dense — is that deliberate? — that is the question, and I have not found it answered plainly anywhere I have looked. Nominating something for promotion into the documentation commons. The…	+83	91	49k	18mo
Common supplements people ask about, assessed one at a time Practice › Interactions insulin needs a source hypoglycaemia metformin Common supplements people ask about, assessed one at a time — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been doing the same…	+101	107	28k	12h
What the published dose-response for semaglutide actually looks like above 2.4 mg — a second dataset Compounds › Semaglutide STEP programme randomised trial SELECT trial type 2 diabetes Solved Asking directly, because I could not find a straight answer: What the published dose-response for semaglutide actually looks like above 2.4 mg — a second dataset Session topic: SURMOUNT-1 ( N Engl J Med ,…	+112	130	2.2k	16mo
Documentation that appears only after payment Sourcing › Red flags documentation quality moderation mislabelling disputed Solved Documentation that appears only after payment Writing it up because I had to work it out twice and would rather nobody else did. I would like to talk about documentation quality as a signal, separately from…	+113	124	13k	7mo
Revisiting: German, French and Dutch differences, compared Regional › European Union personal import formulary EMA cost per milligram Posting this under the heading it deserves: Revisiting: German, French and Dutch differences, compared Everything below is what sits behind that. A coverage question with the paperwork detail included, since…	+90	99	32k	9mo
High-resolution MS on aggregates and what it can see Analytics › Mass spectrometry charge states counter-ion content high-resolution MS Posting this under the heading it deserves: High-resolution MS on aggregates and what it can see Everything below is what sits behind that. Working through the identity arithmetic and I would like it checked.…	+117	123	6.5k	8mo
A partial dose because the pen emptied mid-injection Practice › Administration subcutaneous injection needle gauge & length injection site rotation missed dose Solved A partial dose because the pen emptied mid-injection Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+108	120	1.5k	7mo
A site rotation scheme that is easy enough to actually follow Practice › Administration needle gauge & length missed dose injection site rotation aseptic technique On the subject in the title: A site rotation scheme that is easy enough to actually follow Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly…	+112	125	5.8k	21h
The most useful thing you learned here that was not the answer you came for — a second dataset Lounge › Off topic beginner friendly long read Posting this under the heading it deserves: The most useful thing you learned here that was not the answer you came for — a second dataset Everything below is what sits behind that. Lower-stakes topic, but…	+111	121	6.6k	9mo
The decimal-point error, and the habit that catches it Practice › Reconstitution syringe units concentration maths worked example bacteriostatic water The decimal-point error, and the habit that catches it Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+110	121	10k	7mo
Comparing my trajectory with the trial curves, carefully Outcomes › Progress reports DXA effect size long read data table Solved Posting this under the heading it deserves: Comparing my trajectory with the trial curves, carefully Everything below is what sits behind that. Maintenance rather than loss, which is the part of this that…	+86	92	54k	7mo