Ranked by engagement

Top topics — all time page 6

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

This week This month This quarter This year All time

1,535 topics · page 6 of 40

Topic	Participants	Replies	Views	Activity
Fixed versus detachable needles: the trade-offs Devices › Syringes & needles dead volume subcutaneous injection syringe units worked example Solved Posting this under the heading it deserves: Fixed versus detachable needles: the trade-offs Everything below is what sits behind that. I have read the maintained page on this and I still have a gap, so I am…	+117	121	7.3k	18mo
A well-designed study with a badly written abstract Evidence › Study critique disputed effect size risk of bias observational data Posting this under the heading it deserves: A well-designed study with a badly written abstract Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with LEADER ( N Engl J Med ,…	+117	128	7.2k	14mo
Follow-up: Individual participant data versus aggregate data Evidence › Meta-analyses meta-analysis effect size publication bias heterogeneity Individual participant data versus aggregate data — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURPASS-4 ( Lancet , 2021) and finding the…	+101	111	23k	18mo
TB-500 and thymosin beta-4: the fragment versus the protein Compounds › Repair & healing peptides observational data TB-500 BPC-157 preprint TB-500 and thymosin beta-4: the fragment versus the protein Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a…	+107	118	22k	11mo
Where to report an adverse event officially, by region — a second dataset Safety › Adverse events gallbladder delayed gastric emptying vomiting hypoglycaemia On the subject in the title: Where to report an adverse event officially, by region — a second dataset Working notes rather than a conclusion. Asking about a population rather than about a person. The…	+108	123	26k	8mo
Citing a preprint in a maintained document: our rule and its reasoning — does this still hold? Evidence › Preprints preprint needs a source effect size Solved Under review The question in the title: Citing a preprint in a maintained document: our rule and its reasoning — does this still hold? I will give what I have already checked below so nobody repeats it. I have seen LEADER…	+103	115	24k	10mo
Converting between mg/mL and units per dose, both directions — the long version Practice › Reconstitution reconstitution worked example syringe units dead volume Converting between mg/mL and units per dose, both directions — the long version Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated,…	+110	132	1.7k	3mo
Can a home kit substitute for a laboratory report? A careful no Analytics › Home & field testing third-party testing documentation quality LOD & LOQ ELISA Solved Asking directly, because I could not find a straight answer: Can a home kit substitute for a laboratory report? A careful no I would like to understand what this number means before I repeat it anywhere. A…	+122	131	1.7k	5mo
Why "dose equivalence" between different incretin analogues is a weak concept Practice › Dosing & titration tirzepatide dose reduction titration semaglutide Solved Why "dose equivalence" between different incretin analogues is a weak concept I have a specific reason for asking rather than idle curiosity, and the context is below. I have read the maintained page on this…	+124	133	11k	5mo
Personal import allowances, compared — a second dataset Access › International personal import telehealth MHRA EMA Wiki Personal import allowances, compared — a second dataset — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what…	+124	132	9.2k	2mo
Journal club: is percentage weight change the right endpoint? Evidence › Journal club number needed to treat randomised trial journal club Solved Journal club: is percentage weight change the right endpoint? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing SURPASS-4 ( Lancet , 2021) with SURMOUNT-OSA (…	+116	120	23k	3mo
Pinch or no pinch, and how needle length changes the answer Practice › Administration injection site reaction aseptic technique needle gauge & length missed dose Pinch or no pinch, and how needle length changes the answer Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a gap,…	+118	126	11k	9mo
Reference intervals: how they are constructed and why one in twenty flags Clinical › Bloodwork HbA1c thyroid function eGFR & renal function lipase & amylase Under review Reference intervals: how they are constructed and why one in twenty flags — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I…	+104	119	30k	1mo
What is genuinely unknown about long-term amylin agonism Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema amylin analogues Solved What is genuinely unknown about long-term amylin agonism — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing STEP 8 ( JAMA , 2022) with SURMOUNT-1 ( N Engl J Med…	+83	91	46k	1d
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ Sourcing › Independent verification blind sampling PeptideMeter Medutest third-party testing How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ I have a specific reason for asking rather than idle curiosity, and the context is below. Structured report rather than an opinion, following…	+117	130	3.3k	14mo
Second pass at: Adsorptive losses at low concentration, and why dilute solutions are fragile Practice › Storage & stability beyond-use date freeze-thaw cloudy or discoloured solution storage Closed On the subject in the title: Second pass at: Adsorptive losses at low concentration, and why dilute solutions are fragile Working notes rather than a conclusion. Practical question with the units stated,…	+77	87	58k	4mo
Spreadsheets: an appreciation — what changed since Lounge › Off topic long read beginner friendly Spreadsheets: an appreciation — what changed since — setting out what I have, and where I think it stops being reliable. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim.…	+102	113	26k	17h
Reading a trial's population section before its results Evidence › Trials estimand surrogate endpoints discontinuation & dropout randomised trial Solved On the subject in the title: Reading a trial's population section before its results Working notes rather than a conclusion. I have seen STEP 2 ( Lancet , 2021) cited in support of a claim I do not think it…	+91	109	22k	2mo
Submitting a sample: the process end to end Sourcing › Independent verification blind sampling PeptideMeter VendorInvestigate third-party testing On the subject in the title: Submitting a sample: the process end to end Working notes rather than a conclusion. I would like to talk about documentation quality as a signal, separately from product quality.…	+99	114	29k	21h
An ABAB design with a data table and honest limitations — a second dataset Research Methods › N-of-1 designs confounding effect size data table worked example Solved On the subject in the title: An ABAB design with a data table and honest limitations — a second dataset Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before…	+106	118	25k	4mo
The "under review" status pill and when a moderator applies it Evidence › Preprints risk of bias effect size preprint Posting this under the heading it deserves: The "under review" status pill and when a moderator applies it Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it…	+96	119	17k	3mo
A report I filed that turned out to be wrong, and the correction Sourcing › Vendor reports certificate of analysis disputed third-party testing A report I filed that turned out to be wrong, and the correction Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an opinion, following the…	+124	132	12k	13mo
Obstructive sleep apnoea and a hard endpoint in this class Clinical › Comorbidities chronic kidney disease PCOS obstructive sleep apnoea blood pressure On the subject in the title: Obstructive sleep apnoea and a hard endpoint in this class Working notes rather than a conclusion. Asking about a population rather than about a person. The published trials in…	+120	129	1.8k	13mo
Coming back to: An 18-month record including the parts that went badly Outcomes › Progress reports DXA effect size long read Solved Posting this under the heading it deserves: An 18-month record including the parts that went badly Everything below is what sits behind that. Longitudinal report with the method stated, because a number…	+83	89	52k	12mo
Stepping down deliberately, and how to do it without losing progress Practice › Dosing & titration worked example semaglutide tirzepatide dose reduction Stepping down deliberately, and how to do it without losing progress — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…	+98	102	26k	3mo
Identical chromatograms across two different lots Sourcing › Red flags mislabelling underdosing documentation quality Identical chromatograms across two different lots Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than…	+80	87	58k	18mo
I joined for one answer and stayed for a year — what changed my mind Start Here › Welcome guidelines onboarding trust levels Posting this under the heading it deserves: I joined for one answer and stayed for a year — what changed my mind Everything below is what sits behind that. Question in the title. Context below, and I have…	+96	114	17k	just now
Official shortage notices and what they authorise Access › Shortages compounding formulary shortage Posting this under the heading it deserves: Official shortage notices and what they authorise Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this…	+106	119	18k	1mo
Trust level 3 requirements: a clarification — does this still hold? Meta › Announcements trust levels moderation site feedback guidelines Solved Asking directly, because I could not find a straight answer: Trust level 3 requirements: a clarification — does this still hold? Process question about how this site works. I have read the guidelines and the…	+76	90	57k	9h
Research-use-only labelling: what it means and what it does not Sourcing › Regulatory compounding research use only EMA FDA Posting this under the heading it deserves: Research-use-only labelling: what it means and what it does not Everything below is what sits behind that. I would like to talk about documentation quality as a…	+100	110	37k	5mo