Latest topics page 49

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 49 of 52

Topic	Participants	Replies	Views	Activity
Follow-up: Escalating every six weeks instead of four: what I observed over eight months Practice › Dosing & titration titration worked example tirzepatide dose reduction Escalating every six weeks instead of four: what I observed over eight months — setting out what I have, and where I think it stops being reliable. Two things I would like separated before anyone answers on…		4	164	20mo
A side-effect grading scheme this community uses, and its limits — the long version Practice › Side effects nausea vomiting hair shedding constipation Solved A side-effect grading scheme this community uses, and its limits — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about side-effect grading scheme,…	+19	23	29k	20mo
Why I ask for the gradient before I discuss the number Analytics › HPLC & UHPLC gradient method data table HPLC system suitability The question in the title: Why I ask for the gradient before I discuss the number I will give what I have already checked below so nobody repeats it. I would like to understand what this number means before I…	+35	39	4.9k	20mo
A revision dispute resolved on the topic rather than in the history — a second dataset Meta › Wiki maintenance moderation citation check maintainership wiki post Solved On the subject in the title: A revision dispute resolved on the topic rather than in the history — a second dataset Working notes rather than a conclusion. Posting a small dataset on revision dispute…	+44	50	33k	20mo
Reading a preclinical wound-healing model and its relevance to a human tendon Compounds › Repair & healing peptides TB-500 preprint observational data Wiki Closed On the subject in the title: Reading a preclinical wound-healing model and its relevance to a human tendon Working notes rather than a conclusion. Posting a small dataset on reading a preclinical…	+149	160	3.3k	20mo
Type 1 diabetes: off-label use and the evidence gap — what changed since Clinical › Special populations adolescents disordered eating older adults Solved Type 1 diabetes: off-label use and the evidence gap — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Type 1 diabetes is wrong?…	+68	77	31k	20mo
Revisiting: Melanocortin agonists: mechanism and the documented adverse profile Compounds › Other compounds custom synthesis mislabelling research use only Solved Posting this under the heading it deserves: Revisiting: Melanocortin agonists: mechanism and the documented adverse profile Everything below is what sits behind that. Melanocortin agonists, from the point of…	+119	141	22k	20mo
Follow-up: Recovery when intake is low: what to cut first Nutrition & Training › Resistance training DXA lean mass loss fatigue Posting this under the heading it deserves: Recovery when intake is low: what to cut first Everything below is what sits behind that. A follow-up question about Recovery that I did not know to ask the first…	+36	40	38k	20mo
How to ask for a dose change without antagonising anyone — what changed since Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes Solved How to ask for a dose change without antagonising anyone — what changed since — that is the question, and I have not found it answered plainly anywhere I have looked. A question about how to describe…	+81	92	10k	20mo
[2026 update] Insulin combinations and hypoglycaemia risk Practice › Interactions needs a source hypoglycaemia metformin Insulin combinations and hypoglycaemia risk Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Insulin combinations and hypoglycaemia risk. It is…		2	2.8k	20mo
Choosing which test to pay for, given a fixed budget — does this still hold? Sourcing › Independent verification PeptideMeter blind sampling Janoshik Analytical VendorInvestigate Choosing which test to pay for, given a fixed budget — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. A question about how a record should be…	+35	39	755	20mo
Training through a dose escalation week Nutrition & Training › Resistance training lean mass loss DXA fatigue Training through a dose escalation week — setting out what I have, and where I think it stops being reliable. What changes if the standard account of training through a dose escalation is wrong? I ask because…		4	42k	20mo
EMA product information as a primary source — does this still hold? Regional › European Union EMA cost per milligram formulary personal import Solved Closed The question in the title: EMA product information as a primary source — does this still hold? I will give what I have already checked below so nobody repeats it. Something about EMA product information does…	+127	150	41k	20mo
Revisiting: Five questions in one post gets you one answer — how to split them Start Here › How to Ask worked example guidelines beginner friendly site feedback Solved Revisiting: Five questions in one post gets you one answer — how to split them Writing it up because I had to work it out twice and would rather nobody else did. Working notes on Five questions rather than a…	+2	6	13k	20mo
Merging two pages that cover the same ground — the long version Documentation › Wiki requests promoted to docs review date maintainership wiki post On the subject in the title: Merging two pages that cover the same ground — the long version Working notes rather than a conclusion. Bringing the figures rather than the impression, since a process question…	+5	9	209	20mo
Melanocortin agonists: mechanism and the documented adverse profile Compounds › Other compounds needs a source mislabelling research use only custom synthesis Melanocortin agonists: mechanism and the documented adverse profile — setting out what I have, and where I think it stops being reliable. Melanocortin agonists, and specifically the version of it that the…	+7	11	5.5k	20mo
Chronic kidney disease and the FLOW result — a second dataset Clinical › Comorbidities MASH / hepatic steatosis blood pressure type 2 diabetes Chronic kidney disease and the FLOW result — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Chronic kidney disease. It is mine,…		2	2.3k	20mo
A well-designed study with a badly written abstract — does this still hold? Evidence › Study critique disputed confounding risk of bias Solved Closed A well-designed study with a badly written abstract — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about well-designed study on behalf…		2	28k	20mo
US compounding rules and how they changed Regional › North America FDA telehealth insurance Closed US compounding rules and how they changed — setting out what I have, and where I think it stops being reliable. Reporting a regional experience with the date and the jurisdiction attached, because an undated…	+62	68	1.4k	20mo
Transporting a vial for a weekend away Practice › Storage & stability temperature excursion freeze-thaw beyond-use date cloudy or discoloured solution Closed On the subject in the title: Transporting a vial for a weekend away Working notes rather than a conclusion. Transporting a vial, and specifically the version of it that the documentation does not cover. The…	+39	45	35k	21mo
Second pass at: Reimbursement variation across member states Regional › European Union personal import formulary cost per milligram EMA On the subject in the title: Second pass at: Reimbursement variation across member states Working notes rather than a conclusion. The question about Reimbursement variation across member states that I…	+23	28	45k	21mo
Time to steady state after a dose increase Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose On the subject in the title: Time to steady state after a dose increase Working notes rather than a conclusion. Working through the kinetics rather than the pharmacology, because I think the confusion here is…	+151	163	9.7k	21mo
[2026 update] Comparing tirzepatide and semaglutide is harder than the tables suggest Compounds › Tirzepatide effect size SURMOUNT programme tirzepatide randomised trial Comparing tirzepatide and semaglutide is harder than the tables suggest Writing it up because I had to work it out twice and would rather nobody else did. Putting the numbers in the first post, because a…		2	23k	21mo
Signs of dehydration worth acting on Safety › Adverse events gallbladder delayed gastric emptying pancreatitis vomiting Solved Signs of dehydration worth acting on — setting out what I have, and where I think it stops being reliable. Signs of dehydration worth acting, from the point of view of someone who has read the documentation…	+34	38	5.9k	21mo
Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content cloudy or discoloured solution sterile water storage Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. A formulation question rather than a pharmacological one, though the two…	+11	15	51k	21mo
Second pass at: Food noise reducing and the disorientation that can follow Wellbeing › Mental health beginner friendly disordered eating mood Closed Second pass at: Food noise reducing and the disorientation that can follow — setting out what I have, and where I think it stops being reliable. Two things I would like separated before anyone answers on Food…	+55	59	965	21mo
Irish differences from the UK position Regional › UK & Ireland MHRA cost per milligram NHS Solved Posting this under the heading it deserves: Irish differences from the UK position Everything below is what sits behind that. Trying to establish the boundary conditions on irish differences. The general…	+62	66	993	21mo
Hypertension improvement and when medication needs revisiting — a second dataset Clinical › Comorbidities blood pressure type 2 diabetes obstructive sleep apnoea MASH / hepatic steatosis Posting this under the heading it deserves: Hypertension improvement and when medication needs revisiting — a second dataset Everything below is what sits behind that. Posting a small dataset on Hypertension…	+126	133	22k	21mo
Second pass at: Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content cloudy or discoloured solution sterile water Wiki Second pass at: Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Buffers. It is mine, it is…	+24	28	1.5k	21mo
Relative retention time as a better inter-laboratory comparator — does this still hold? Analytics › Method validation LOD & LOQ precision & repeatability stability-indicating method recovery Solved Wiki Relative retention time as a better inter-laboratory comparator — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard…	+11	15	21k	21mo